Jacob Roth

MD/PhD student and aspiring physician scientist. #doubledocs he/him/his

[Jacob Roth @JacobRoth13]

@kreidermr1 Well you could have led with the fact that it’s your study/work! Looking forward to reading. Thanks for sharing: https://t.co/jE8dOfGdeH

[Montefiore Health System @MontefioreNYC]

We are profoundly grateful that Dr. Ruth Gottesman, Professor Emerita of Pediatrics at @EinsteinMed, has made a transformational gift to #MontefioreEinstein—the largest to any medical school in the country—that ensures no student has to pay tuition again. https://t.co/XOy9HZLbfD

[Robert Aboukhalil @RobAboukhalil]

Really excited to unveil https://t.co/3DKXXBuxFD, an interactive playground for learning bioinformatics command-line tools like bedtools, bowtie2, and samtools (and more to come!) 🧑‍💻 🧬

Thanks to @aaronquinlan, @BenLangmead, and @mike_schatz for feedback and tutorial ideas.

[David Shechter @DShechter]

Ever wonder why histone chaperones have acidic tails?

Our new preprint reveals they mimic DNA to regulate chromatin! Glutamate-glutamylation enhances their mimicry.

Dive in: https://t.co/n1MIumdmGe lead by @B_Lorton23 Chris Warren @HumairaIlyas8 #biorxiv 1/7

[NCATS @ncats_nih_gov]

Discover insights into #GeneTherapy, #NaturalLanguageProcessing in scientific research, and more in our latest e-newsletter! Subscribe to stay informed: https://t.co/YcslwL0NHo 📰

[David Shechter @DShechter]

Very excited to share this preprint we contributed to - this work is generally important as it shows that the nuclear/cytoplasmic *density* ratio is highly conserved.

This is a unique insight has broad implications for how the genome is regulated. See thread below:

[APSA @A_P_S_A]

Our panel on #doubledocs interviews Q+A is about to start! Looking forward to hearing from our excellent panelists from @MSU_DOPhD, @Columbia #MSTP, @UWMSTP, and @DukeMSTP. Join us for our interactive session, keep track of the conversation with this thread, or watch on @YouTube!

[Jacob Roth @JacobRoth13]

@CTTriggs @0_minyaaa Glad to see this had already been commented 👌🏼

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Massive misuse of chemical probes undermines the utility of these tools https://t.co/VrYv59Uy6u

[Jacob Roth @JacobRoth13]

@ThePhDPlace Free seminar food

[Stephen Turner 🦋 @stephenturner.us @strnr]

Anyone familiar with an R package for visualizing these kinds of gene constructs, as in dnaplotlib (python) https://t.co/mhQLldvkVP ggbio and other genome browser / track-based tools aren't really what I'm looking for. #Rstats

[Laura Luebbert, PhD @NeuroLuebbert]

I created a Colab tutorial that checks if a gene/transcript ID has an associated crystal structure, checks if related proteins with associated crystal structures are available, and then compares those to a de novo structure prediction:

https://t.co/P24WrJzhpR

[Simona Cristea @simocristea]

Only a matter of time before a paper formalized this exercise:

Automated #scRNAseq cell type annotation with GPT4, evaluated across five datasets, 100s of tissues & cell types, human and mouse.

A🧵below with my thoughts on how such tools will change how #Bioinformatics is done.

[Justin Becker @JustinSBecker]

These kinds of non-canonical (mis-expressed) tumor antigens are so fascinating, and warrant greater attention! Exciting to think about how their expression might be detected / enhanced / targeted in our patients. Great step forward in this paper. https://t.co/pQLTKl1Qc8

[bioRxiv @biorxivpreprint]

3D genome organization around nuclear speckles drives mRNA splicing efficiency https://t.co/8sXEpX0Ezx #bioRxiv

[National Cancer Institute @theNCI]

A combination of drugs has shown promise for treating children with rhabdomyosarcoma. But can the potential therapy get to clinical trials? https://t.co/7yKaP3pFUI
#ChildhoodCancer @cogorg

[Libusha Kelly @microbegrrl]

Your gut is producing sulfide as you read this tweet! Join @anaerobicwolf Reese Hitchings and #teamsulfide @EinsteinMed with @EdGoluch reporting a novel mechanism of xenobiotic metabolism by the gut microbiome https://t.co/h8A9BJpfX9 https://t.co/7qVIoXajPC @NatMetabolism
a🧵

[Nature Reviews Drug Discovery @NatRevDrugDisc]

For readers interested in targeting RNA structures with small molecules, which Matthew Disney is presenting on at #BostonDOT22 now, here's a recent review https://t.co/Yu6UTvG7QC

[Nature Methods @naturemethods]

Out today and freely available, a tool many in the image analysis community have been waiting for!

PyImageJ: A library for integrating ImageJ and Python

@EliceiriK @UWMadisonLOCI @ctrueden @CiminiLab @DrAnneCarpenter

https://t.co/2sjWSfJJ8n

[Carey Jansen, MD PhD @careyjans]

Hey #doubledocs! Quick poll for those of you who took a *scored* STEP1 exam but will be applying to residency with an MD-cohort with predominantly (or all) *pass-fall* results... would you prefer:

@A_P_S_A @Inside_TheMatch @jbcarmody #MedStudentTwitter @medstudentchat