Thomas Lab

We study the role and regulation of NADPH oxidases in immunity -

[Thomas Lab @DThomasLab]

Our latest paper on EROS has now been published in @eLife! A great collaborative effort @fra_magnani and many more! https://t.co/Sq53ZLllly

[Thomas Lab @DThomasLab]

Delighted to be co-leading this collaboration with Nic Wisniacki at GSK
A £50million plus investment in towards a better understanding of renal and respiratory disease. More here:
https://t.co/v1iTtyscIz

[Thomas Lab @DThomasLab]

Very exciting paper from @ALNeehus and @casanova_lab

[Anna-Lena Neehus @ALNeehus]

1/ Exactly one year after my PhD defense, I am very excited to share with you the last chapter of my thesis published today in @Nature about humans with inherited TNF deficiency: https://t.co/qzsRqPC3pU.

[Thomas Lab @DThomasLab]

@David_J_Adams Always presumed you didn't

[Thomas Lab @DThomasLab]

@ALNeehus @EMBO @EMBOFellows @bloodgenes amazing news ! well done and so well deserved!

[Thomas Lab @DThomasLab]

this is an excellent opportunity!

[Peters Lab @lab_peters]

Interested in #genomics? Fulled funded UKRI PhD studentship available in @lab_peters at @imperialcollege London. UK Home students eligible for this scheme.

[Thomas Lab @DThomasLab]

looking forward to reading this!!

[Thomas Lab @DThomasLab]

UK transplant will miss the wonderful @frank_dor - good luck in your new post and come back often !

[Hannah Maple @TransplantMaple]

Dear @RotterdamTrans, thank you for loaning @frank_dor to London for the last few years.
Frank, thank you for everything. We will miss you. Don’t be a stranger! 😘
@Bynvant @KessarisN @KikiSran @CityUrology @Mr_G_Papadakis @CJCallaghanTx @LoukopoulosI @rhz59 @PGogalniceanu

[Thomas Lab @DThomasLab]

@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab Finally, we identified a population of transcriptionally distinct monocytes that emerged in peripheral blood following glucocorticoid treatment - the “dex monocyte” do have a read !

[Thomas Lab @DThomasLab]

delighted to have worked with @lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab on this study. great work by first authors Emily Stephenson, Lisa Dratva and Erin Macdonald-Dunlop. Thanks to all our patients most of all

[Teichlab @teichlab]

Our study on severe #COVID19 in end stage kidney disease patients with matched pre-pandemic samples from a broad cohort of 61 individuals is on medRxiv! https://t.co/MGQK96ULzp

[Thomas Lab @DThomasLab]

@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab Evaluation of clonal T cell dynamics showed that the fastest expanding clones were significantly enriched in known SARS-CoV-2 specific sequences and shared across multiple patients. Our analyses also revealed novel TCR clones that are likely reactive to SARS-CoV-2.

[Thomas Lab @DThomasLab]

@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We identified gene expression signatures of severity, with the majority of pathways differentiating mild from severe disease in B cells and monocytes.

[Thomas Lab @DThomasLab]

@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We used single-cell RNA-seq, CITE-seq and immunoreceptor sequencing, derived from 187 longitudinal samples from 61 patients.

[Thomas Lab @DThomasLab]

@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We collected samples before and during COVID-19 infection from the same individuals. We performed dense longitudinal sampling during infection, allowing us to study intra-individual changes over time among patients with a wide spectrum of COVID-19 severity.

[Thomas Lab @DThomasLab]

@lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab We studied two cohorts of end-stage kidney disease patients prior to the introduction of vaccination. This is one of the patient groups most at risk from severe COVID-19.

[Thomas Lab @DThomasLab]

@JamesCranley @mallat_lab @kazukane @teichlab Huge congratulations James !

[Adrian Liston @LabListon]

I've put together a set of links for the various career development advice articles I've been writing for the past ~20 years, here arranged by career stage:

https://t.co/Vbovz2MiVq

Hope it is helpful to some people!

[Thomas Lab @DThomasLab]

Great opportunity !

[Brian Ferguson @viropractor]

I'm recruiting a Postdoc for a comparative innate immunity project to define cross-species mechanisms of pathogen sensing, in collaboration with @ClareBryant13 and Sandhya Ganesan. Can involve travel to partners in India. Please RT. Full advert here: https://t.co/3u0NzeYVz2

[Benjamin Stewart @drbstewart]

A privilege and honour to receive the Raine award and I hugely enjoyed sharing our science at #UKKW2024

[Thomas Lab @DThomasLab]

@Dr_James_Lee The paper outlines the central role of ETS2 in driving macrophage inflammatory responses, dissects how this distal enhancer for ETS2 expression is a risk locus in numerous genetic studies and outlines new therapeutic possibilities in IBD.

Even a bit of ROS too !

[Thomas Lab @DThomasLab]

So great to see this work published and delighted to have collaborated with the Lee lab. Fantastic work from Christina Stankey, Christophe Bourges, Lea Maxie Haag and colleagues, led @Dr_James_Lee

https://t.co/7Qxuo7ACA5