Dan Mangels

[Dr Paddy Barrett @Paddy_Barrett]

Is it possible to reverse coronary artery disease?

I get this question all of the time.

🧵👇

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[Cardiology Today @CardiologyToday]

Valentin Fuster: The PRE-CAD study will examine if intensive treatment in young patients with LDL > 70 makes a difference in plaque. “The risk factors at age 20 to 40 mean more than the risk factors at age 60 to 100” @HeartinDiabetes #HiD2023 @MountSinaiHeart @YHandelsmanMD

[Dan Mangels @DanMangelsMD]

Increased all-cause mortality in low flow (stroke volume index) and discordant moderate aortic stenosis compared to concordant moderate aortic stenosis https://t.co/B1orMTEEml

[Dan Mangels @DanMangelsMD]

Two interesting meta-analyses demonstrating small reduction in LDL cholesterol levels from garlic intake https://t.co/jOWCZhN9Ss and https://t.co/YSW0tafXVt

[Dan Mangels @DanMangelsMD]

First time AF following post-op non-cardiac surgery shares similar embolic risk at 6 years mean follow-up compared to non-operative AF. https://t.co/MExxzWGAj9

[Dan Mangels @DanMangelsMD]

https://t.co/tirbtAQgxy
Increasing data that small peridevice leaks 5 mm or less with Watchman associated with relative higher incidence of stroke compared to no leak.

[Dan Mangels @DanMangelsMD]

https://t.co/Md6WOMz7ky Retrospective look at OAC use for AF in elderly (mean age 78.5) and frail (Hospital Frailty Score 5 or more) population demonstrating net clinical benefit in NACE reduction compared to no OAC without significant major bleeding risk.

[Dan Mangels @DanMangelsMD]

https://t.co/xA4Fk1voiJ Interesting reassessment of the relationship between PCWP and exercise related HFpEF.

[Dan Mangels @DanMangelsMD]

Meta-analysis of varying combination of HFrEF medical therapy on primary endpoints identifying combination of ARNi, BB, MRA, & SGLT2i as most effective in reducing all-cause death (HR: 0.39; 95% CI: 0.31-0.49).
https://t.co/Bf0MxrNud0

[Dan Mangels @DanMangelsMD]

Growing data for signal of benefit in treating asymptomatic severe or very severe AS.
Asymp very severe AS w/ SAVR; RCT: https://t.co/zyMFAu5Kdo
Asymp severe AS w/ SAVR; RCT: https://t.co/D72KUwVXWV
Asymp severe AS outcomes; retrospective: https://t.co/0tUrGDPlEk

[Dan Mangels @DanMangelsMD]

Significant reductions in BP with both aerobic and resistance training: https://t.co/zwzBXdYyGD

[Dan Mangels @DanMangelsMD]

Had a great time reviewing recent updates on the growing and evolving field of VA ECMO!

[UC San Diego Cardiology Fellows @UCSDCardFellows]

Another round of senior talks today! @DanMangelsMD discussed the cutting edge data on VA-ECMO and Dr. Jason Duran discussed research on COVID-19 in transplant patients.

[Doug Darden @djdardenMD]

Elegantly written perspective on mentorship @UCSDCardFellows

https://t.co/aQtLjFc7Qi

[Dan Mangels @DanMangelsMD]

Favorable data in support of earlier use of Impella with AMI-CS. Note however relatively high utilization of ECMO in both early and during-after PCI groups as part of an escalation approach. https://t.co/bHqzmsYntx

[EHJ Editor-in-Chief @ehj_ed]

Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials: now in EHJ
https://t.co/DixnAI1S0K
#cardiotwitter @ESC_Journals @escardio

[American College of Cardiology @ACCinTouch]

In pts w/ NSTE-ACS undergoing early invasive treatment, downstream & upstream oral P2Y12 inhibitor admin. strategies were associated w/ low incidence of ischemic & bleeding events & minimal numeric difference of event rates between treatment groups. More: https://t.co/9XpmGDWKpg

[Dan Mangels @DanMangelsMD]

A low-fat vegan diet seems to outperform Mediterranean diet with respect to LDL-C reduction & (modest) weight loss in this 4-month crossover study, though BP reduction better w/ the latter: https://t.co/jInQlv2BXy

[Dr. Deepak L. Bhatt @DLBHATTMD]

2020 ACC Expert Consensus Pathway for Anticoagulant and Antiplatelet Therapy - American College of Cardiology https://t.co/qRSUIyTaJN @JACCJournals @cpcannon @beaverspharmd @GBarnesMD #cardiotwitter #cardiology

[American College of Cardiology @ACCinTouch]

A #JACC paper, coauthored by Dr. Salim Yusuf, suggests that further limiting intake of saturated fat may not improve #CVD prevention or reduce mortality: https://t.co/o2SYr6fpkm #NYCVS20

[Eric Topol @EricTopol]

What can your saliva, smartphone, #CRISPR and 15 minutes get you?
A quantitative #COVID19 test result w/ viral load
https://t.co/3nvCrenSPV @ScienceAdvances by @Tony_Y_Hu @Tulane and collaborators