Daniel Roche

Tertiary Knowledge Manager at SOPHiA Genetics the creators of Alamut and SOPHiA DDM. PhD in Bioinformatics. All opinions are my own.

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2026 #NobelPrize in Chemistry to Henri B. Kagan and Kenso Soai “for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis.”

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

[Shauns_Aviation🇮🇪✈️ @Shauns_Aviation]

Not your regular flight into Shannon🦅

This evening 2 US Airforce F-15’s diverted to shannon due to the tanker escorting them dealing with tech issues.

The 2x aircraft landed and taxied to a nearby apron to refuel before continuing onwards.

📸: Follower

#aviation #avgeek #ShannonAirport #Ireland #US #Military

[Irish Embassy Paris @IrlEmbParis]

📺Minister of State for European Affairs @ThomasByrneTD was interviewed by @France24 after Ursula von der Leyen's State of the Union address.

Discussions focused on child social media ban and 2028-2034 budget.

Watch the full interview: https://t.co/4CRikYYvCF

[Protein Data Bank @PDBeurope]

A predicted interaction may involve only a small region of a protein complex.
How can we identify confidence in that local interface when surrounding regions have high PAE?
Our tutorial uses PAE matrix to explain how LIS can help 👇
https://t.co/fWp6U20WVM
#AlphaFold #AlphaFoldDB

[Irish Embassy Paris @IrlEmbParis]

L'ambassadrice désignée Alison Milton a eu le plaisir de rencontrer le créateur et artisan irlandais Joseph Walsh lors d'une visite de son exposition à Paris, qui se tient du 10 septembre au 25 octobre. À ne pas manquer !

[Protein Data Bank @PDBeurope]

Same predicted complex, different confidence scores:

ipTM: 0.38
ipSAE: 0.75

Why can these metrics differ? Full breakdown 👇
https://t.co/fWp6U20WVM

#AlphaFold #AFDB

[Protein Data Bank @PDBeurope]

🎥 The AlphaFold-Multimer prediction for your protein looks great. But how confident should you actually be in it?
Razan Abbara breaks down the 5 confidence metrics behind every AFDB multimer entry:
pLDDT · ipTM · ipSAE · pDockQ2 · LIS👇
https://t.co/fWp6U20WVM
#AlphaFold #AFDB

[Protein Data Bank @PDBeurope]

🚀 Depositors can now submit structures directly to the OneDep system from the structure determination software via a newly developed Deposition API.

Available now in Phenix and CCP-EM Doppio, with CCP4 and Global Phasing support coming soon.

⬇️ more ⬇️
https://t.co/XthRmOqUmL

[Irish Embassy Paris @IrlEmbParis]

La Fédération de Football Gaélique s’engage au côté de l’association Colosse aux Pieds d’Argile pour prévenir les violences dans le sport et promouvoir des environnements sûrs, respectueux et inclusifs.

[Diamond MX Beamlines @Diamond_MX]

New PDB Deposition from I04 https://t.co/bWGL5EgRab

[Protein Data Bank @PDBeurope]

🚨 Big PDB changes are one year away

Starting July 21, 2027:

▪ PDB Beta Archive becomes the main archive.
▪ Extended PDB IDs and PDBx/mmCIF will be the standard.

Start using extended IDs and PDBx/mmCIF today!

🔗 https://t.co/2YVwjyZ3mr

#PDB #StructuralBiology

[ISCB News @iscb]

The VarI poster session continues today at #ISMB2026! Attendees can vote for best talks/posters at: https://t.co/otMGI3sMDI

Make sure to get your vote in by 2pm EDT!

[Diamond MX Beamlines @Diamond_MX]

New PDB Deposition from @beamlineI24 https://t.co/akPjes7BJh

[Irish Embassy Paris @IrlEmbParis]

Joyeux 14 juillet ! De Wolfe Tone aux “Wild Geese”, l’histoire franco-irlandaise est faite de fraternité révolutionnaire. Une amitié forgée par les siècles, toujours vivante aujourd’hui 🇮🇪🇫🇷

[Irish Embassy Paris @IrlEmbParis]

Les délégués irlandais se sont joints à leurs homologues de toute l'Europe pour annoncer un programme passionnant d'événements destinés à célébrer l'Année européenne des Normands en 2027!

[ACMG @TheACMG]

Variants of uncertain significance (VUS) remain one of the most challenging aspects of genetic testing. ACMG's new Points to Consider statement provides evidence-based recommendations to support consistent reporting and interpretation. https://t.co/E18xQUtUlJ #VUS

[Irish Embassy Paris @IrlEmbParis]

As Ambassador Niall Burgess leaves Paris after 4+ years of posting, the relationships he built and the goodwill he fostered will continue to strengthen the ties between Ireland and France for years to come.

Go raibh míle maith agat, thank you very much Ambassador!

[Irish Embassy Paris @IrlEmbParis]

L'Ambassadeur Niall Burgess est arrivé à Paris en déc 2021, juste à temps pour célébrer le centenaire de l'Ulysse de Joyce. Sa dernière réception en tant qu'ambassadeur célébrait Bloomsday.
Pour un admirateur de Joyce, on ne pouvait rêver de meilleur au-revoir.
Merci pour tout !

[Protein Data Bank @PDBeurope]

🚀 The PDBe Graph Server is built for power users.

Explore the PDBe-KB Neo4j schema with AI-assisted Cypher generation - including nodes, and edges

🔗 Graph DB:
https://t.co/3dsJzPpAEh

#Neo4j #KnowledgeGraph #PDBe #AI #Cypher