Daniel Gehrlach

Neuropsychopharmacology, Precision Psychiatry

[Dom Oliver @Dom__Oliver]

🚨 New preprint: Can LLMs help assess psychosis risk from clinical interviews?

Early detection is key—but current approaches rely on specialist interpretation, limiting scalability.

We tested whether open-weight LLMs can help ����👇

[Naval @naval]

Vibe coding is more addictive than any video game ever made (if you know what you want to build).

[Daniel Gehrlach @daniel_gehrlach]

@ApitiusHofmann Heute ganz schön in München.. Mauritius ist toll, aber ich fand den Fahrstil der Mauritier unerträglich 😂.

[Daniel Gehrlach @daniel_gehrlach]

If I was furniture, I would be a secretary desk. Full of fun facts!

Aphantasia helps me in neurobiology and clinical drug development, as concepts, pathways, brain regions, etc. are just handed up.

However, regarding episodic memory, I am more of a sieve 😂

[Tom Ebeyer @tomebeyer]

https://t.co/1s9Gt353W6

[Paul Brown @0xQuasark]

A 1,000-year-old drug kit was found in a Bolivian cave.

Inside: five psychoactive compounds, including the exact recipe for ayahuasca.

Cocaine. DMT. Harmine. Bufotenine. Possibly psilocin.

The largest collection ever found in a single South American artifact.

None of these plants grow within 𝘩𝘶𝘯𝘥𝘳𝘦𝘥𝘴 𝘰𝘧 𝘮𝘪𝘭𝘦𝘴 of that cave.

Someone was running a continent-wide psychedelic supply chain in 950 AD.

That's 500 years before Columbus "discovered" the Americas.

[Daniel Gehrlach @daniel_gehrlach]

@JD_Rosenblat @JAMAPsych Methylone 🙃 .. haha non-hallucinogenic, true.

But it´s also a very strong rave-o-genic ����🥳🥳.

Coining this a "neuroplastogen" is highly misleading and shall then apply to MDMA, as well.

[Daniel Gehrlach @daniel_gehrlach]

@psybalazs I really don't see what's so funny in comparing the absolute changes across treatment modalities (+-therapy/dosing regimen) and indications (TRD). Wouldn't it instead be much more a amusing to compare effect sizes, odds ratios or number needed to treat?

[Daniel Gehrlach @daniel_gehrlach]

@ladygreenkirtle When and why did we even stop coming up with new surnames?

[Brad Stulberg @BStulberg]

A massive new study on peak performance included 34,000 international top performers: Nobel laureates, renowned classical music composers, Olympic champs, and the world’s best chess players. It shows early specialization is a trap, and the road to greatness is long and varied.

[Daniel Gehrlach @daniel_gehrlach]

Whaaaat?

[Lev Chizhov @ennucore]

Can ultrasound make you smell things that aren’t there?

Turns out, yes! We reliably triggered distinct scents like a campfire burn or a garbage truck by targeting our brains with ultrasound. To our knowledge, this has never been done before, even in animals.

This may be a promising modality for writing to the brain non-invasively:
🧵 1/

[Daniel Gehrlach @daniel_gehrlach]

Check out my guest piece for Clinical Leader:

How AI Is Transforming Patient Stratification in Clinical Trials https://t.co/wHVqILlkL3

[Daniel Gehrlach @daniel_gehrlach]

@levelsio Earth’s finest Golgafrinchan heritage on display

[Daniel Gehrlach @daniel_gehrlach]

@quintinfrerichs Love this. Chance for true precision health. I just hope it's not a bit too early for that, as most science and payors are focused on treating disease. We're working on the HPA achsis, which you will probably find central for enhancement as a master energy regulator.

[Daniel Gehrlach @daniel_gehrlach]

If a healthy and fulfilled person, blessed with cherished friends and experiences, got to run my day, I am quite sure it would look very different than the "competent" CEO.

[James Clear @JamesClear]

A Monday morning question for you:

If a competent CEO got to run your life for a day, what is the first thing they would eliminate?

[Daniel Gehrlach @daniel_gehrlach]

@itsolelehmann Check out Porto, Augsburg, Innsbruck

[Daniel Gehrlach @daniel_gehrlach]

Die meisten Bots sind aus Botugal, wenige aus Botswana. Sie sprechen aber alle Botugiesisch

[Daniel Gehrlach @daniel_gehrlach]

😁😝

[Massimo @Rainmaker1973]

Programmers were asked to make the worst volume control for a contest
https://t.co/DcwMiDAGm2

[Max Hodak @maxhodak_]

When nature has a problem to solve, it makes a protein. Now, with the help of AI, what we used to have to do with electronics or optics we can increasingly do through biology.

Starting with the world’s most sensitive optogenetic channels.

Paper linked below ⬇️

[Daniel Gehrlach @daniel_gehrlach]

Would be great to have a 🔙 button in @Office Outlook, to get back to that one email you have finally found after a long tedious search in your inbox - but lost it again, because you quickly checked the new urgent mail.

Something like "recently viewed" would already help a lot.

[Neurotorium @neurotorium]

What causes depression❓
Learn all about neurobiology and aetiology of MDD via our educational slide deck: https://t.co/nI5DMLMVMK
You can download the 30+ slides, all free, no sign-up required