Emilie Mace

Neuroscientist and brain imager. Professor at @yourUMG @MBExC_de. Previously Max Planck Research Group Leader at @MPIforBI

[Emilie Mace @EmilieMaceLab]

1/8. Preprint!✨How spontaneous is spontaneous behavior?🧠🐭
We found that whole-brain fUSi signals predicted spontaneous behavior transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching!
https://t.co/bBZZO7jZAy

[IOB.ch @IOB_ch]

👁‍🗨We turn science into sight.
Congratulations to our Director @IOB_Roska on receiving the 2026 Future Vision Award alongside Connie Cepko & Daniel Ting. A recognition of long-term research now reaching patients.
🎬Watch the short movies: https://t.co/mbWgbGdpbN
#Vision #Retina #Ophthalmology #Blindness #Neuroscience #ScienceInnovation #VisionRestoration #EyeHealth #BiomedicalResearch

[Emilie Mace @EmilieMaceLab]

8/8. This work builds on inspiring studies showing that internal states shape spontaneous behavior over long timescales.🕜

Huge thanks to co-authors, institutions, and funders for making this possible! 🙏
@yourUMG @MPIforBI DFG @EKFStiftung @MBExC_de

[Emilie Mace @EmilieMaceLab]

1/8. Preprint!✨How spontaneous is spontaneous behavior?🧠🐭
We found that whole-brain fUSi signals predicted spontaneous behavior transitions seconds in advance. Inhibiting one node of this transition-prone state, the medial septum, facilitated switching!
https://t.co/bBZZO7jZAy

[Emilie Mace @EmilieMaceLab]

7/8. In short:
~10 s before a spontaneous behavioral switch:
↑ decodability
↓ medial septum activity (and other regions)

Our interpretation: internal drive gradually builds up, creating a transition-prone brain state that makes switching more likely.

[tommaso patriarchi @tpatriarchi]

Wait… localized norepinephrine transients in the awake visual cortex?!
Who would have guessed this neuromodulatory signal is that spatially precise, right where visual processing is happening. Brain state control just got a lot more local. https://t.co/e4OGR9dlTB

[Emilie Mace @EmilieMaceLab]

8/8 Last but not least: Jose Maria is looking for a postdoc in computational neuroscience 🧠💻 Don’t miss the chance to recruit him — he comes highly recommended! 🚀

[Emilie Mace @EmilieMaceLab]

1/8. New preprint!
Using fUSi in head-fixed mice🐭, we found that arousal events trigger a brain-wide wave of activity 🌊🧠.
Surprisingly, this pattern was preserved during manipulations of the locus coeruleus, pointing to a minor role for noradrenaline.

https://t.co/TqB8VgQ4Hp

[Emilie Mace @EmilieMaceLab]

7/8. In sum: arousal engages a brain-wide hemodynamic wave independent of noradrenergic tone!

Huge thanks to all the coauthors, institutions (@yourUMG , @MPIforBI ), and funders (DFG, EKFZ, @MBExC_de) for making this possible! 🙏

[TENSS @tenss_ed]

Deadline extended for TENSS 2026 to March 15th!

[Emilie Mace @EmilieMaceLab]

@maxhodak_ @mardinly Congrats, @mardinly !