Darcie Chan

Author of the Mill River series from @PenguinRandom. Former Senate attorney. Still a small-town Midwestern girl at heart!

[Columbus Library @columbuslibrary]

Dolly Parton was a champion for literacy. She gave more than 304 million books to children around the world, shaping the future of our youth in an enormous way.

May her legacy live on through the millions of memories gifted to the world and children alike. ❤️

[NASA Goddard @NASAGoddard]

A stellar Coat of Many Colors for Dolly Parton, forever among the stars 💗

[Darcie Chan @DarcieChan]

Brilliant, lol!

[Janel Comeau 🍁 @VeryBadLlama]

I have recalled
the groceries
that are in
your pantry

and which
you were probably
planning
to eat

forgive me
they’re full of salmonella
and maybe
broken glass

[Darcie Chan @DarcieChan]

@seizuresalad That is really beautiful!

[Darcie Chan @DarcieChan]

@thespybrief Absolutely. And the best coffee, too!

[Darcie Chan @DarcieChan]

This is important— colon cancer rates are rising among younger people. We may now know why.

[Sam Knowlton @samdknowlton]

Colorectal cancer rates in adults under 50 have doubled since the late 1980s.

One in five colorectal cancer diagnoses now occurs in someone under 55, up from one in ten in 1995.

A new study highlights the most concrete factor responsible for this trend.

Using DNA methylation profiles as molecular records of lifetime exposure, the authors compared cancer patients under 50 with patients over 70 and identified the herbicide picloram as a significant new risk factor.

There are converging lines of evidence.

The picloram exposure signature was significantly elevated in early-onset tumor tissue and replicated across nine independent patient cohorts. Across 21 years of US county-level data spanning seven states, higher picloram use tracked higher early-onset CRC incidence, and the signal held after adjusting for income, education, and the use of other pesticides.

Picloram associated tumors also showed a distinct molecular profile, with APC mutations at 74% versus 90% in low-exposure tumors, suggesting these cancers follow a different biological pathway than classical CRC.

Picloram entered commercial use in 1964. Patients now diagnosed in their 70s were already adults before meaningful exposure was possible. Patients now diagnosed in their 30s and 40s were exposed across childhood and adolescence, the developmental windows when epigenetic programming is most plastic.

This study delivers the first triangulation of molecular, ecological, and temporal evidence pointing at a specific environmental driver of one of the steepest cancer trends in modern epidemiology.

[Darcie Chan @DarcieChan]

@seizuresalad One of this year’s babies!

[Darcie Chan @DarcieChan]

@seizuresalad It is my happy place for sure!

[Darcie Chan @DarcieChan]

@seizuresalad You could name the business Jurassic Jewelry!

[Darcie Chan @DarcieChan]

@seizuresalad I love that smell…like early spring after rain, when things are just beginning to sprout.

[Darcie Chan @DarcieChan]

Brilliant, and very appropriate for today.

[Sandra Boynton @SandyBoynton]

Reposting my son's July 4th poem.

[Darcie Chan @DarcieChan]

@seizuresalad My deepest condolences. I am glad you were able to be with her at the end.

[Darcie Chan @DarcieChan]

@thespybrief New TSB site, new kitten. Meet Rosemary. Ten weeks old and an absolute sweetheart.

[Darcie Chan @DarcieChan]

"What greater gift than the love of a cat". -- Charles Dickens
You were the smartest and most loving cat. Rest in peace, my sweet girl.

[Darcie Chan @DarcieChan]

Eloquent, heartfelt, and exactly right. Every American should read this.

[Molly McKew @MollyMcKew]

The US Capitol
Arlington Cemetery
The White House
The American wilderness

America has sacred spaces. Trump profanes them all.

https://t.co/vXHItGO58j

[Darcie Chan @DarcieChan]

This is a fantastic novel! https://t.co/aTZWbNyXCB

[Darcie Chan @DarcieChan]

@thespybrief Yep. The freaking-out has begun....

[Darcie Chan @DarcieChan]

@thespybrief And, of course, that's assuming the move is legal. The immigration statues are collectively a huge dumpster fire, with many governing provisions. But, I doubt whether such a dramatic increase in the visa fee can be done without congressional approval.

[Darcie Chan @DarcieChan]

@thespybrief Here's hoping. It would fit his pattern. Either carve-outs or walking things back.