📢📢📢O-glycans play a significant role in VWF biology! If you're interested for more have a look in our newly published paper in Blood Advances. Special thanks to all the co-authors and funding agencies. @ProfJSODonnell@RCSI_Irl@IrishCtrVascBio https://t.co/fgoIAiM8bE
Age-dependent effects on plasma VWF levels in type 1 VWD define distinct subgroups with important differences in underlying pathogenesis. https://t.co/9o9wdETrtg #thrombosisandhemostasis
Important paper in press in @BloodJournal. There are two groups of type 1 VWD, those that increase with age and those whose levels do not change. Diagnosis of type 1 VWD depends on age when the person was tested and later their levels are likely to be higher and often normal. https://t.co/Mg9z3T1Shl #VWD #Willebrand
Missing my fellow VWD nerd @sortoutbleeding but at least St. James Dublin is still well represented!…@DearbhDoherty with a phenomenal provocative preclinical study that may someday force DDAVP into retirement !! #ASH2023 Shoulda been an oral abstract!!!
CALL FOR RESEARCH PARTICIPANTS:
WHO? Women/people with potential to menstruate aged 18+
WHY? To learn about menstrual health, bleeding experiences and physical activity. Survey open to both people who have a bleeding disorder and the general public.
Link: https://t.co/S3PTCU4vo2
Looking for a new research challenge? Come join us in the heart of Dublin City @RCSI_Irl for a cross-disciplinary research project examining the crosstalk between #cancer and #coagulation details in the link below @PostdocRcsi#JobAlert#postdoc
https://t.co/FBBR0UkP9E
Subtle enhanced VWF clearance is present in 20% of patients with low VWF and is associated with an attenuated bleeding phenotype. https://t.co/BiyMPkkD1S #stimulusreport
T1/2 FVIII in #hemophilia pts is influenced by plasma VWF:antigen levels, ABO blood group &age. @EinasElsheikh et al show heterogeneity in clearance endogenous plasma VWF is 🔑determinant variable FVIII half-life in pts.
@sortoutbleeding@ProfJSODonnell
https://t.co/QVuifiPkTO
Normal ageing ▶️📈variability in #bleeding scores amongst healthy women, related both to step-wise increases in menorrhagia domain scores and accrual of post-procedural bleeding with increasing exposure to procedures.
▶️https://t.co/iXOR0fQQlu
Great start to 2023 seeing our @JTH paper published, highlighting variability in ISTH-BAT with normal ageing. Fantastic to collaborate with @james_paulad &other #Zimmerman investigators! @ProfJSODonnell@sortoutbleeding @pamchristophers @RCSIPharmBioMol
https://t.co/duyOqxakse
People with von Willebrand Disorder often don’t know they have it.
If you get heavy nosebleeds or bleed for longer than normal you could have VWD.
Learn more through our #FindingvonWillebrand campaign.