James ODonnell

[Blood Journals Portfolio @BloodPortfolio]

Mild isolated functional VWF defects in the 30 to 50 IU/dL range are common and are associated with significant bleeding in some patients. https://t.co/x0GLhfLHPq #thrombosisandhemostasis #clinicaltrialsandobservations

[RCSI @RCSI_Irl]

New RCSI research has identified a previously unrecognised subgroup of patients with the bleeding disorder von Willebrand disease.

The findings challenge current diagnostic practices and highlight a need to adapt clinical guidelines.

➡️ https://t.co/Uztrq7zoqT

#RCSIdiscover

[Ulster University Nursing and Paramedic Science💙 @UlsterUniSoNP]

Celebrating the great news of promotion to Professor of nursing for our colleague @dodonnell22 @ulsterunisonp Congratulations Professor O’Donnell!! We are #proudofuu #ulsternurse #ulsterparamedics

[Deirdre O'Donnell RN, PhD, SFHEA @dodonnell22]

Delighted to be promoted to Professor of Nursing. Thanks to everyone who has supported me and believed in me.

[lynn malec @malecly]

Montgomery Educational Symposium on Hemostasis (MESH) was a huge success thanks to the incredibly bright minds and warm hearts that gathered to honor ‘Montgomery, Milwaukee’s’ amazing career @VersitiResearch

[The John Durkan Leukaemia Laboratories @DurkanLab]

President of Haematology Association of Ireland @Paulv8205 giving an overview of 25 years of the #HAI and recognition of Liam O’Connell - Ireland’s first haematologist.
@stjamesdublin @tcddublin @CancerInstIRE

[Blood Journals Portfolio @BloodPortfolio]

BT200 interaction with the VWF-A1 domain in proximity to this lysine cluster significantly attenuates macrophage LRP1-mediated clearance. https://t.co/ESmTKFXYlk #thrombosisandhemostasis

[Jim luyendyk @TFFVIIa]

Very excited to share our science and kick off new collaborations. Coffee is also mentioned, which is excellent.

[RCSI School of Pharmacy and Biomolecular Sciences @RCSIPharmBioMol]

REMINDER: Our next #PBSResearch seminar series supported by @thermofisher is tomorrow Tues. 1st Oct. at 3pm in the Cheyne LT.

We are thrilled to welcome Prof. James Luyendyk (@TFFVIIa) from @michiganstateu to see his fascinating work ‘targeting vWF to accelerate liver repair’🔬

[flora peyvandi @flora_peyvandi]

#BT200 prolongs VWF half-life by attenuating macrophage-mediated clearance and specifically the interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. A anovel therapeutic approach for #von Willebrand disease and #hemophilia. https://t.co/sFL92J0O90

[Michael Makris @ProfMakris]

Valuable information on the mode of action of BT200 published in @BloodAdvances. It blocks VWF clearance through LRP1. BT200 is a treatment being developed for non-type 3 von Willebrand disease. https://t.co/TojOj3bZA9 #VWD #VWF #Willebrand

[JTH @JTHjournal]

👀Let’s take a peek at the story that made our #october #coverart

In #vWD type vicenza, #vWF clearance is accelerated. How⁉️

🧬 Atiq et al. showed that the VWF-R1205H mutation leads to loss of positive charge and increased binding to macrophage clearance receptors via LRP1 and SR-AI.

A significant novel insight into the mechanism of this complex disease.

✍️@DavidLillicrap @Jme_os @ProfJSODonnell

https://t.co/hLTS1b0wXx

[SETH Trombosis y Hemostasia @SETH__Oficial]

▶ Advanced analysis of platelet metabolism and mitochondrial function
Sonia Águila, @Sonia_AguilaM, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, UCAM, Murcia (Spain)

▶ How is NO metabolism regulating platelet function Paolo Gresele, University of Perugia (Italy)

▶ Platelet heterogeneity in health and disease
Paul C. Armstrong, Queen Mary University of London Centre for Immunobiology, Blizard Institute (United Kingdom)

@isth #SETH #PlateletResearch #plaquetas #platelet #Murcia

[Blood Journals Portfolio @BloodPortfolio]

Novel functions for von Willebrand factor
https://t.co/ryxVDxXAsx #thrombosisandhemostasis #vascularbiology

[RCSI @RCSI_Irl]

Dr Alain Chan Kwo Chion @RCSIPharmBioMol features in the @siliconrepublic list of researchers to follow 🔬

Based at @IrishCtrVascBio his research focuses on approaches to treat the common bleeding disorder von Willebrand disease.

More ➡️ https://t.co/ms7LxQGMjB

#RCSIdiscover

[Nature Reviews Disease Primers @DiseasePrimers]

The gene encoding von Willebrand factor is located on the short arm of chromosome 12, and a highly homologous pseudogene that does not generate functional transcripts has been mapped on chromosome 22. #VWD https://t.co/Z8bljvO6mh

[IBTS Education & Research @ibts_education]

Prof. Hervig will be sorely missed by all in the IBTS. We wish him a very happy retirement!

[Nature Reviews Disease Primers @DiseasePrimers]

von Willebrand factor synthesis occurs in endothelial cells and megakaryocytes as a single-chain polypeptide that, subsequently, undergoes extensive processing. #VWD https://t.co/Z8bljvO6mh

[Nature Reviews Disease Primers @DiseasePrimers]

Our NEW Primer on von Willebrand disease is live today!
By @OmidSeidi, Eikenboom, @cecile_denis, @VeronicaFlood18, @james_paulad, @LentingPeter, Baronciani, @ProfJSODonnell, @DavidLillicrap & @flora_peyvandi #Hematology #VWD
Check it out here: https://t.co/G7bSR2ODXr

[JTH @JTHjournal]

VWF-R1205H (Vicenza), known for causing enhanced clearance of VWF,

▶️causes conformational changes in the VWF-D’D3 domains &

enhances VWF binding to clearance receptors LRP1 and SR-A1.
@ProfJSODonnell @IrishCtrVascBio @RCSI_Irl @DavidLillicrap @Jme_os https://t.co/kvOud985kr