Mild isolated functional VWF defects in the 30 to 50 IU/dL range are common and are associated with significant bleeding in some patients. https://t.co/x0GLhfLHPq #thrombosisandhemostasis#clinicaltrialsandobservations
New RCSI research has identified a previously unrecognised subgroup of patients with the bleeding disorder von Willebrand disease.
The findings challenge current diagnostic practices and highlight a need to adapt clinical guidelines.
➡️ https://t.co/Uztrq7zoqT
#RCSIdiscover
Montgomery Educational Symposium on Hemostasis (MESH) was a huge success thanks to the incredibly bright minds and warm hearts that gathered to honor ‘Montgomery, Milwaukee’s’ amazing career @VersitiResearch
BT200 interaction with the VWF-A1 domain in proximity to this lysine cluster significantly attenuates macrophage LRP1-mediated clearance. https://t.co/ESmTKFXYlk #thrombosisandhemostasis
REMINDER: Our next #PBSResearch seminar series supported by @thermofisher is tomorrow Tues. 1st Oct. at 3pm in the Cheyne LT.
We are thrilled to welcome Prof. James Luyendyk (@TFFVIIa) from @michiganstateu to see his fascinating work ‘targeting vWF to accelerate liver repair’🔬
#BT200 prolongs VWF half-life by attenuating macrophage-mediated clearance and specifically the interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. A anovel therapeutic approach for #von Willebrand disease and #hemophilia. https://t.co/sFL92J0O90
Valuable information on the mode of action of BT200 published in @BloodAdvances. It blocks VWF clearance through LRP1. BT200 is a treatment being developed for non-type 3 von Willebrand disease. https://t.co/TojOj3bZA9 #VWD#VWF#Willebrand
👀Let’s take a peek at the story that made our #october#coverart
In #vWD type vicenza, #vWF clearance is accelerated. How⁉️
🧬 Atiq et al. showed that the VWF-R1205H mutation leads to loss of positive charge and increased binding to macrophage clearance receptors via LRP1 and SR-AI.
A significant novel insight into the mechanism of this complex disease.
✍️@DavidLillicrap@Jme_os@ProfJSODonnell
https://t.co/hLTS1b0wXx
▶ Advanced analysis of platelet metabolism and mitochondrial function
Sonia Águila, @Sonia_AguilaM, Centro Regional de Hemodonación, IMIB-Pascual Parrilla, UCAM, Murcia (Spain)
▶ How is NO metabolism regulating platelet function Paolo Gresele, University of Perugia (Italy)
▶ Platelet heterogeneity in health and disease
Paul C. Armstrong, Queen Mary University of London Centre for Immunobiology, Blizard Institute (United Kingdom)
@isth #SETH #PlateletResearch #plaquetas #platelet #Murcia
Dr Alain Chan Kwo Chion @RCSIPharmBioMol features in the @siliconrepublic list of researchers to follow 🔬
Based at @IrishCtrVascBio his research focuses on approaches to treat the common bleeding disorder von Willebrand disease.
More ➡️ https://t.co/ms7LxQGMjB
#RCSIdiscover
The gene encoding von Willebrand factor is located on the short arm of chromosome 12, and a highly homologous pseudogene that does not generate functional transcripts has been mapped on chromosome 22. #VWD https://t.co/Z8bljvO6mh
von Willebrand factor synthesis occurs in endothelial cells and megakaryocytes as a single-chain polypeptide that, subsequently, undergoes extensive processing. #VWD https://t.co/Z8bljvO6mh
VWF-R1205H (Vicenza), known for causing enhanced clearance of VWF,
▶️causes conformational changes in the VWF-D’D3 domains &
enhances VWF binding to clearance receptors LRP1 and SR-A1.
@ProfJSODonnell@IrishCtrVascBio@RCSI_Irl@DavidLillicrap@Jme_os https://t.co/kvOud985kr