Deneris Lab

Serotonin neurobiology lab at the @CWRUSOM Department of Neurosciences | Account maintained by lab members | Views = our own

[Clay Spencer @WClaySpencer]

A brain circuit and neuronal mechanism for decoding and adapting to change in daylength https://t.co/7uMsEx1nEU

[Deneris Lab @Deneris_lab]

Thanks @MSoizaReilly and @TrendsNeuro!
If you're interested in how neurons are protected against degeneration, check out the awesome commentary on our recent findings in #serotonin neurons.

[Trends in Neurosciences @TrendsNeuro]

A ‘Spotlight’ commentary by @MSoizaReilly discusses recent findings by @Deneris_lab on the maintenance of transcriptional programs of #serotonin (5-HT) neurons, & how progressive decay of these transcriptomes may contribute to neurodegenerative processes
https://t.co/2Bd8PZwV0z

[Deneris Lab @Deneris_lab]

@MSoizaReilly @TrendsNeuro thanks so much for this commentary!! Evan was really excited to see it! -Deneris lab

[Dhananjay Yellajoshyula @dyellaj]

Excited to announce that the Yellajoshyula lab will start at Case Western. It’s an honor to call the CWRU Neurosciences faculty my colleagues. I will cherish my memories @ U Michigan. Excited for the new chapter with the Collins lab (@CathyFlyMom).
https://t.co/WWQEXpawTV

[Deneris Lab @Deneris_lab]

@eLife Congrats to @xinruizhng @cwrumstp and @WClaySpencer on their work, with the help from Nobuko Tabuchi, @MeaganKitt, and other crucial members of the Deneris lab!
6/6

[Deneris Lab @Deneris_lab]

Interested in the #epigenetic control of neurodevelopment?
Check out our recent study @elife in which we showed that terminal selector-type transcription factors orchestrate the #chromatin accessibility of postmitotic #serotonin (5-HT) neurons. A 🧵-
https://t.co/aqJNjaZhUl
1/n

[Deneris Lab @Deneris_lab]

@eLife In doing so, Pet1/Lmx1b ensure that the acquisition of distinct neuron functional properties (e.g. transmitter synthesis, synapse formation) are developmentally coupled. Genetic perturbation of these proteins alters gene expression and disrupts the formation of 5HT connectivity.

[Deneris Lab @Deneris_lab]

Congrats to the talented Deneris lab undergrads Carolyn Devadoss, Derick Casiano, and Keaton Markey on their graduation this weekend. Best of luck to your new beginnings! We can't wait to see what's next in your journey.

[Ashley Nemes-Baran, Ph.D. @Nemes_Ashley]

@CWRUSOM @CWRUartsci @cwru congratulations to all students graduating this weekend, but I am especially proud of our second graduating class of the new Neuroscience Major! #graduation2022 #cwru22 #cwruclassof2022

[Cell Reports @CellReports]

An adult-stage transcriptional program for survival of serotonergic connectivity https://t.co/TjvXzbFzrM

[Deneris Lab @Deneris_lab]

Congratulations to @MeaganKitt and Nobuko Tabuchi on the excellent work, with the help from @WClaySpencer, @heathlarsson from @themeilab, @xinruizhng, and other crucial members of the @Deneris_lab!

[Deneris Lab @Deneris_lab]

Ever wonder how neurons maintain their health and functions throughout decades of life?

In this recent work, we showed that Lmx1b and Pet1 sustain an adult-stage connectivity transcriptome in #serotonin (5-HT) neurons. A thread 🧵-
https://t.co/uQK42lgLkO
1/n

[Deneris Lab @Deneris_lab]

Our findings suggest that neuronal connectivity is transcriptionally protected by maintenance of connectivity transcriptomes. Progressive decay of such transcriptomes may contribute to age-related diseases of #brain circuitry.
4/n

[Deneris Lab @Deneris_lab]

Grateful to @elife for sharing our preprint under review!

[eLife - the journal @eLife]

Reviewers described this preprint as a “major technical achievement” and a “tour-de-force effort” employing cutting-edge methods to study the molecular mechanisms underlying serotonergic neuron maturation.

Check out the full reviewer comments here: https://t.co/euRya4qRT6

[Deneris Lab @Deneris_lab]

@HTB_soFLY @WClaySpencer Thanks!

[Xinrui Zhang @xinruizhng]

This was so much fun to work on!!
Excited to share our preprint on how transcription factors control the chromatin accessibility of synapse, axon, and neurotransmission genes in postmitotic serotonin neurons.