Derek Croote

Co-founder & CTO of clinical-stage antibody therapeutics co @IgGenix | Following trials with @trialinference | Previously @Stanford bioengineering PhD

[Derek Croote @DerekCroote]

@001TMF And/or maybe has to due with the plugins? Hard to tell https://t.co/z7vW4f2ONl

[Derek Croote @DerekCroote]

@OpenAI Are the benchmarks run with the Life Sciences plugin enabled? And does the plugin materially change results e.g., does the GPT-5.5 delta to GPT-Rosalind meaningfully narrow with the plugin? Maybe @ChrisHayduk you might know?

[Derek Croote @DerekCroote]

@OpenAI Are the benchmarks run with the Life Sciences plugin enabled? And does the plugin materially change results e.g., does the GPT-5.5 delta to GPT-Rosalind meaningfully narrow with the plugin? Maybe @ChrisHayduk you might know?

[Derek Croote @DerekCroote]

Nice to see Claude Opus 4.8 refusing fewer biology questions than 4.7.

It's now also recognizing the error-prone nature of correctly reproducing long sequences:

"I can't provide the exact full amino acid sequence of... as I'm not confident I can reproduce it with the precision required. Sequence data like this is the kind of information where small errors (a single wrong residue) can be significant, and I don't want to give you something that looks authoritative but contains mistakes."

[Derek Croote @DerekCroote]

More journals should offer manuscripts in both human-readable PDF and machine-readable XML like @MDPIOpenAccess does.

[Derek Croote @DerekCroote]

@NikoMcCarty PTMs? Esp for tx

[Derek Croote @DerekCroote]

@signulll it was foretold https://t.co/uTVM9f2Y1O

[Derek Croote @DerekCroote]

The year is 2026 and not a single brand on amazon contains an English word. New companies are spawned by the blind smash of a fist on the z x w q side of the keyboard. Vowels are banned. Each product has 2.5 million 5 star reviews. They're all written by AI. There are so many we need AI summaries. The summary is never helpful. The product images are AI too. Buy it Now happens automatically if you stare at an item too long. Nothing is what you want. Doesn't matter. Commerce enlightenment has been achieved.

[Derek Croote @DerekCroote]

@owl_posting behold https://t.co/J0U4ThZCIO

[Derek Croote @DerekCroote]

exceptional clinical trial title

[Derek Croote @DerekCroote]

exceptional clinical trial title

[Derek Croote @DerekCroote]

@_sholtodouglas the biology refusals are quite frustrating https://t.co/kqoFQBioDT

[Derek Croote @DerekCroote]

Because of all the refusals (via API and separately in chat) I get significantly lower performance on my biotech benchmark that covers antibody therapeutics, tox, clinical dev, cell surface receptors, food allergens, and biological sequences.

[Derek Croote @DerekCroote]

@KisslingLucas @ScienceTM @Francesca_Pietr Very cool, congrats.

[Convoke @Convokebio]

Today we're publishing our index of unmet needs in human disease: 2443 indications scored and ranked on burden of disease, prevalence, pipeline activity, and treatment burden. We hope this will help drug developers identify overlooked medical problems

https://t.co/OX4BKC8cfI

[Derek Croote @DerekCroote]

@hhlee @p_maverick_b @ATinyGreenCell @SynBio1 https://t.co/VnadV8rRRL

[Derek Croote @DerekCroote]

after repeatedly trimming and simplifying the prompt, the conclusion is that claude doesn't like post-translationally cleaved proteins. [diff below shows the deletion necessary for claude to not refuse the prompt; no data was attached to prompt]

[Derek Croote @DerekCroote]

@nlarusstone @AnthropicAI biological analysis refusals are painfully common

https://t.co/FtMkSiFcaE

[Derek Croote @DerekCroote]

after repeatedly trimming and simplifying the prompt, the conclusion is that claude doesn't like post-translationally cleaved proteins. [diff below shows the deletion necessary for claude to not refuse the prompt; no data was attached to prompt]

[Derek Croote @DerekCroote]

yep seems to be it

[Derek Croote @DerekCroote]

Genuinely bewildered. Claude refusing to analyze ELISA and SPR binding data. I even tried removing (contentious ??) terms like "antibody" and "antigen"

[Derek Croote @DerekCroote]

after repeatedly trimming and simplifying the prompt, the conclusion is that claude doesn't like post-translationally cleaved proteins. [diff below shows the deletion necessary for claude to not refuse the prompt; no data was attached to prompt]

[Derek Croote @DerekCroote]

@patrick_oshag from the 80s, but quite good. the cuckoo's egg: tracking a spy through the maze of computer espionage

[Derek Croote @DerekCroote]

@sama Biology!

[Derek Croote @DerekCroote]

@TensorTwerker @ByteDanceOSS unavailable it seems: "Please note that the accessibility of the protenix-v2 checkpoint is currently under review... We are unable to provide a specific timeline at this stage" - https://t.co/W9HoWeXTFP

[Derek Croote @DerekCroote]

@unusual_whales i raise you to $7.89 in south san francisco