DevermanLab

Engineering viral vectors for gene therapy @stanleycenter @broadinstitute

[Addgene @Addgene]

📣🎉New pooled library! This screening library from George Church's lab contains all possible single codon substitutions, deletions, and insertions in the AAV2 cap gene.

https://t.co/krbqJ7ywNU

[DevermanLab @DevermanLab]

@Addgene Honored to have one of our plasmids posted as Addgene plasmid of the day! BI28 is a highly efficient capsid for CNS transduction in all strains of mice. It was engineered by reprogramming AAV9 to bind LY6C1 in vitro.

[Addgene @Addgene]

iCAP-BI-28-KanR
Depositor: @DevermanLab
Purpose: RepCap for AAV production

https://t.co/jnXeRa3emI

[DevermanLab @DevermanLab]

@RossWilsonLab @StanleyCenter @broadinstitute @atchen_ @azari_ba @Fatma_zahra_Eid @Ayjchan Thanks Ross! I completely agree that this is a concern and a place where ML should be able to help.

[DevermanLab @DevermanLab]

We have released a preprint “Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions”.

We developed gene delivery vectors with known mechanisms of action & predictable tropisms by targeting AAVs to specific proteins.

https://t.co/ObDwFiOoCC

[DevermanLab @DevermanLab]

This work was made possible by our @StanleyCenter @broadinstitute team:
Helen Huang
@atchen_
Ken Chan
Hikari Sorensen
Andrew Barry
@azari_ba
Thomas Beddow
Qingxia Zheng
Binhui Zhao
Isabelle Tobey
@Fatma_zahra_Eid
@ayjchan

[DevermanLab @DevermanLab]

We believe this strategy will accelerate the development of AAV gene delivery vectors that bind defined targets on different disease-relevant cell types with high specificity and across species to enable translation from preclinical models to investigational human gene therapies.

[ASGCT @ASGCTherapy]

Early-career scientists: We want to fund your pilot studies in #genetherapy & #celltherapy!

ASGCT Members can apply for one of six $100,000 #CareerDevelopment awards by Aug. 1. Learn more and apply today! https://t.co/NYpOcSnd8S

[DevermanLab @DevermanLab]

We’re thrilled to have Andy join our team!

[Olin College @OlinCollege]

ICYMI: Read all about Andy’s ‘10 amazing story - from successful robotics engineer to a machine learning scientist working on gene therapy at the @broadinstitute in @DevermanLab. https://t.co/EYOu778PdJ

[DevermanLab @DevermanLab]

Come see how we are conceptually upending protein evolution approaches by building a machine learning-driven atlas to efficiently identify AAV capsids with multiple desired traits (improved tropisms + manufacturability).

Talk abstract 1201
May 19, 11:45am
@ASGCTherapy #ASGCT22

[DevermanLab @DevermanLab]

Ken Chan from the Deverman lab @broadinstitute @StanleyCenter is presenting data on several AAVs that can efficiently deliver genes to the brain and spinal cord.

Our talk is on May 19, 10:45am
@ASGCTherapy #ASGCT22
Abstract 1197