Ross Wilson

CRISPR whisperer in perpetual training. We're working to enable safe & accessible delivery of genome editing therapeutics. @igisci @UCBerkeley

[Ross Wilson @RossWilsonLab]

Introducing PERCEPT, a non-viral CRISPR delivery platform for in vivo genome editing! We reversibly attach peptides and polymers to CRISPR enzymes, driving editing in the brain, retina, muscle, or lungs of mice via local delivery. 🧵below, bioRxiv🔗https://t.co/KwJi88g3la

[Ross Wilson @RossWilsonLab]

Massive credit goes to Chris Baehr @baehr_chris, who led this work, as well as Alzbeta Ressnerova, Min Kang, Sheng Zhao, Beatrice Le, Rania Haddad & Kunica Asija; Niren Murthy, John Flannery, Victor Van Laar, and Russ Lonser... and all our collaborators!

[Ross Wilson @RossWilsonLab]

Introducing PERCEPT, a non-viral CRISPR delivery platform for in vivo genome editing! We reversibly attach peptides and polymers to CRISPR enzymes, driving editing in the brain, retina, muscle, or lungs of mice via local delivery. 🧵below, bioRxiv🔗https://t.co/KwJi88g3la

[Ross Wilson @RossWilsonLab]

A central finding: the best delivery chemistry (which defines PERCEPT) depended on the tissue. P55 + PEG performed best in lung, while S315 + PEG performed best in muscle. PERCEPT turns protein surface chemistry into a modular toolkit for expanding the reach of genome editing.

[Ross Wilson @RossWilsonLab]

@Ella_Maru Love this! Scariest thing in our lab is... whatever causes our E. coli cultures to collapse for a month, only to vanish as mysteriously as it appeared. Probably phage?

[Ross Wilson @RossWilsonLab]

@chandnirao_here @AnthropicAI @DarioAmodei @mgdurrant Your perspective is spot-on IMO. I didn't think you were suggesting that the citation was missing - that's my own curiosity. It seems very odd that the Korn citation appears only at the end of the manuscript. Typically that would be prominently cited when introducing the locus.

[Molecular Therapeutics Initiative @MTI_UCB]

🧬 Can CRISPR dial down α-synuclein instead of knocking it out?

MTI winners Ross Wilson & Hanqin Li aim to halt Lewy bodies with precision base editing - $90 K + full platform support.

#CRISPR #Parkinsons #MTIAwards

🔗 Read more at https://t.co/7hZ8tSvWkz

[Adair @AdairLBorges]

Inaugural post! (after a long hiatus)

Last May I quit my job to build @dittobio with @Mezarque and @emilycpierce ! We turn parasite molecules into drugs for autoimmune disease, and are part of the @ycombinator W26 batch.

Thanks for betting on us @agupta

[Ross Wilson @RossWilsonLab]

@Nicole_Paulk Nearly an hour? Tons of time to spare! 😅

[Ross Wilson @RossWilsonLab]

@MartinPacesa Thanks, Martin!

[Ross Wilson @RossWilsonLab]

Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - https://t.co/8CL6LIs2Bu - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇

[Ross Wilson @RossWilsonLab]

@jacksonlab @Mizzou Huge credit to @BrigetteManohar for leading this collaborative effort based at IGI & @berkeleyMCB, which would have been impossible without major contributions from OSU's @TNeuroSci_Lab @RussellLonser and support from NIH's SCGE consortium @somaticediting

[Ross Wilson @RossWilsonLab]

@jacksonlab @Mizzou Together, these findings establish Neuro-PERC as a versatile, scalable, well-tolerated platform… as well as a promising candidate for clinical translation in neurotherapeutics. 🐭🐷🧠🧬✂️