when hayao miyazaki said that true love was two people inspiring each other to live...recognizing just how hard living is, putting one foot in front of the other every day, how easy it is to lose our passion for it...... that's the real shit
the whole “i dont like bad bunnys performance because i cant understand” is something my european mind cant comprehend, all the songs on the radio as a kid were in spanish or romanian or french or english and all i spoke was german and i still enjoyed them fully
✌🏽 no hay muchos medios españoles que les importe esto pero algunos hay 🤍 aquí hacemos historia les guste o no y de forma independiente. 2 Grammy latinos y 2 Grammy americano en un mismo año! 1 vez en la historia un malagueño ahí !
🔴El Dr. Mariano Barbacid y su equipo, financiados por #CRISContraelCáncer, han logrado curar el cáncer de páncreas en ratones, de forma duradera y sin efectos secundarios.
Pero necesitamos tu ayuda para que esto sea una realidad en pacientes.
DONA AQUÍ👉https://t.co/4VDU1PrRmA
I won’t shut up about this, pancreatic cancer kills a person in 4 months btw, it’s resistant to radiotherapy, and fucks two essential parts of the metabolism. this could change the world
This isn’t a random scientist who got lucky.
Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.
KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.
The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.
Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.
The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.
Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.