Bruno Di Stefano

The Di Stefano Lab. Post-transcriptional control of cell fate and oncogenesis. Associate Professor & Vivian L. Smith Chair @BCMHouston. Views my own.

[Bruno Di Stefano @DiStefano_Lab]

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵https://t.co/D7fnkJgNQ6

[Barna Lab @mbarnalab]

I’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.

[Chris Sturgeon @Dr_Sturgeon]

I don’t tweet much so I’ll keep this simple

We are looking to recruit 1-2 new postdoctoral fellows, to study human hematopoietic development, from both basic and translational perspectives, using iPSCs.

Please reach out via email for more details if interested!

[Bruno Di Stefano @DiStefano_Lab]

My lab @bcmhouston is hiring a postdoctoral fellow to study hematopoiesis and leukemia using innovative degron mouse models, RNA recording technologies, and functional genomics approaches.

If you are interested, please see the position details below:

[Barna Lab @mbarnalab]

Interesting symposium on ribosome heterogeneity sponsored by Science. Registration is free: https://t.co/520e5eUIpw

[Lluis Morey @lluismorey]

Very excited to share our Molecular Cell @MolecularCell on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators! https://t.co/TKoCZE3FsB

[StemCellReports @stemcellreports]

Dr. Bruno Di Stefano (@DiStefano_Lab), Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!

[Bruno Di Stefano @DiStefano_Lab]

@GallowayLabMIT @kaseyslove Thank you to @kaseyslove and @GallowayLabMIT for the thoughtful and insightful commentary on our work in @NatureBiotech 🙏

[Katie Galloway @GallowayLabMIT]

Sure you can profile RNA but does that actually tell you what a cell will do? Or what it was doing?

Here's a fun reflection led by @kaseyslove on the recent work from the lab @DiStefano_Lab. Their excellent study shows that microRNAs sequester mRNA from the preceding cell fate in P-bodies. Food for thought on how much we can (and cannot) see in profiles of RNA and how we might harness natural sequestration pathways to improve cell fate programming

[Nature Biotechnology @NatureBiotech]

Modulating RNA condensates to control cell fate #NBTNV https://t.co/L5lmwA3CTz

[ISSCR @ISSCR]

Elevate your career in stem cell science! Become an ISSCR member to enjoy exclusive benefits: complimentary webinars, preferred rates for events including ISSCR 2026, publishing benefits, & access to an international network. Join today 👉 https://t.co/asUwFVlhaK @DiStefano_Lab

[Jun Wu Lab @leo_jwu]

Excited to share our new study uncovering and overcoming the molecular drivers of interspecies PSC competition to improve human chimerism in animals. Big congratulations to first authors Yingying, Hai-xian, and Saku, and to our collaborators! https://t.co/2MCeSuwi9O

[StemCellReports @stemcellreports]

Meet Early Career Editor Bruno Di Stefano (@DiStefano_Lab) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!

[Barna Lab @mbarnalab]

This is one of the most interesting papers that I have ever read!

[Bruno Di Stefano @DiStefano_Lab]

8/ Huge thanks to our editor and reviewers for invaluable feedback, and to our funders NIGMS, @theNCI, @NIAIDNews, @ASH_Hematology, @WorldwideCancer, @BePositiveFdn, @WebbWaringAwrds, NICHD, and @CPRITTexas for supporting this work!

[Bruno Di Stefano @DiStefano_Lab]

1/ Excited to share our new study with @Brumbaugh_JB, now out in @NatureBiotech! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵https://t.co/D7fnkJgNQ6

[Bruno Di Stefano @DiStefano_Lab]

7/ Our findings establish a fundamental, conserved role for P-bodies in cell fate specification and reveal novel strategies to manipulate RNA condensates for directing cell identity in regenerative medicine.