Dianne

Biochem made me do it.

[Dianne @Dianndroid92]

Chroma coli by Sydney Rollins & Dianne Moschitta at University of New Hampshire at Manchester
#CellBioEd @CellBioEd #betterposter #SynBioCURE #UNHManchester @UNHManchester

[Dianne @Dianndroid92]

My #lightbulbmoment helped a lot in understanding why E. coli is the "workhorse of biotech". Because it is a prokaryote, DNA replication can occur much faster and within a single cellular location with less DNA, making it the perfect host for cloning genes #hunterbiochemistry

[Dianne @Dianndroid92]

Found an interesting article on a process called autophagy. Normally, this process removes unnecessary or dysfunctional components but according to this study, also plays an important role in lipid homeostasis! #hunterbiochemistry
https://t.co/d5cfH5CXIc

[Plant Physiology @PlantPhys]

Autophagy is required for lipid homeostasis during dark-induced senescence (Jessica A S Barros, Sahar Magen, Taly Lapidot-Cohen, Leah Rosental, Yariv Brotman, Wagner L Araújo, Tamar Avin-Wittenberg) #Autophagy #Lipids #PlantSci https://t.co/3tZdCzeA0A

[Dianne @Dianndroid92]

@Sejlaaga I've heard of lysozyme! It's often among the first steps in making recombinant plasmids. Like you mentioned, it cuts the peptidoglycan in bacterial cell walls, making DNA/RNA extraction much easier.

[Dianne @Dianndroid92]

Something I found interesting was the fact that the total number of aquaporins found in plants is considerably higher than that found in any other kingdom.

[Dianne @Dianndroid92]

This is 1Z98, a closed transport channel/membrane protein in plants (aquaporin) #hunterbiochemistry

[Dianne @Dianndroid92]

It has a length of 281 amino acids. They facilitate the transport of water, neutral solutes and gases throughout a plant. They mainly maintain cellular water homeostasis. This particular image is a crystal structure from a spinach aquaporin.

[Dianne @Dianndroid92]

@Sejlaaga @doudna_lab I was skimming through their website and I was wondering if the researchers at Doudna Lab use E. coli as their choice of chassis in their CRISPR-Cas systems?

[Dianne @Dianndroid92]

@RealWindows Yes! Research on Earth and on the ISS have demonstrated that high intensity resistance workouts are most effective at reducing bone loss. Astronauts use a specialized exercise device called the ARED, which provides both constant and variable resistance, mimicking inertial forces.

[Dianne @Dianndroid92]

Biochemist and American astronaut, Dr. Peggy Whitson, is someone I wanted to briefly touch on. Not only is she the first female commander in the ISS but during her time there, she conducted research studying the molecular mechanisms that dictate bone loss in microgravity.

[Dianne @Dianndroid92]

@MaxDodge6 Thank you so much for showing me this! Plants responding to microgravity by turning their genes on and off, blows my mind. I lost it when the podcast mentioned cell wall remodeling. Incredible. People forget how adaptable and hardy plants can be.

[Dianne @Dianndroid92]

#hunterbiochemistry Hello biochem class! The area of science that currently interests me is astrobotany. Hoping to study plant growth in space environments in the far future 🚀🪴

[Dianne @Dianndroid92]

@Sejlaaga I believe their studies are still ongoing as of early 2020. NASA scientists have been specifically focusing on osteoblasts and osteoclasts and their mechanisms associated with bone and muscle loss in space and on Earth. Here's a brief overview:
https://t.co/hDc1kGKEgY

[Dianne @Dianndroid92]

Thanks to her research, this will lead to better preventative care or therapeutic treatments for people suffering bone loss as a result of bone diseases. Way to go @AstroPeggy 👩🏼‍🚀#hunterbiochemistry