Mit Shah

Cardiology consultant, Prevention, CT & CMR, North West Thames | Runner, aspiring artist, and border collie enthusiast.

[Mit Shah @DoctorMitShah]

🫀 Delighted to share our work on cardiovascular ageing, the subject of my PhD! A mammoth collaborative effort, supervised by the excellent @DrDeclanORegan. Thanks to funders @TheBHF @Bayer.

🔓 @NatureComms https://t.co/BriO7i6Cya

💻 @BBCNews https://t.co/ZuwhlKV19i

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[Mit Shah @DoctorMitShah]

@gabycaptur Thank you for your support during it!

[Mit Shah @DoctorMitShah]

@erica_tirr Thank you!

[Mit Shah @DoctorMitShah]

Very proud to win the Young Investigator Award @BSCImaging 2023! 🏆

Thanks @james_shambrook for organising a brilliant conference in a great city, and @DrDeclanORegan, @MRC_LMS and @TheBHF for their support!

[Mit Shah @DoctorMitShah]

@DrFuSiongNg @DrKiranPatel1 @ImperialNHLI Superb photo and story 🌟

[Mit Shah @DoctorMitShah]

@zahra_raisi Thank you Zahra! It has been great seeing your superb work on similar themes of late

[Mit Shah @DoctorMitShah]

@SukhNijjer @RoySocMed @arunsau_ @drgeorgejoy @DrKiranPatel1 @DrAdamHartley @rajkumar_chris Thanks for organising such a wonderful day! Great supportive environment and lots of excellent discussion.

[Mit Shah @DoctorMitShah]

@hafiz_naderi @alessia_gimelli @cpgale3 @SerioCeline This is amazing? Oil or acrylic?

[Mit Shah @DoctorMitShah]

@drcplymen @FourPillarsGin @AndrewFrankel1 @BSHeartFailure @escardio @m4ggiesimpson @CarysBarton @DrSuePiper @drgrahamcole Highly recommend the bloody Shiraz gin they do

[Mit Shah @DoctorMitShah]

🥸 Conclusions from our work:

⭐️ We have produced a novel ageing signature using ECG and MRI derived from ~ 40K individuals
⭐️ Prospect of CV age to personalise CV risk?
⭐️ Novel genetic associations with CV ageing - prospect for new drug targets?

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[Mit Shah @DoctorMitShah]

🔍 Common Variant Study:

🧬 CV ageing is partially heritable
🧐 Genome-wide significant loci identified & linked to:
- myocardial contractility (Titin)
- arterial mechanics (Elastin)
- pro-inflammatory activity (PLCE1)
- electrical activity
- trabecular development

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[Mit Shah @DoctorMitShah]

🔍 Rare Variant Study:

✨ Using pLoF variants, 2 genes identified for CV ageing beyond common variants.
🧠 TREM2 linked to CNS, macrophages, anti-inflammatory effects in heart repair. 🩺
⚡ MICU3 ties to heart/skeletal muscle, calcium regulation.

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[Mit Shah @DoctorMitShah]

🔍 Risk factors:

🏥 Hypertension (+1.58 yrs), diabetes (+0.74 yrs), obesity in males & CAD in females all associated with accelerated 📈CV ageing.
🚬 Smoking & alcohol associated with 📈CV ageing
🧬 Telomere length linked to 📉CV ageing

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[Mit Shah @DoctorMitShah]

🫀 Delighted to share our work on cardiovascular ageing, the subject of my PhD! A mammoth collaborative effort, supervised by the excellent @DrDeclanORegan. Thanks to funders @TheBHF @Bayer.

🔓 @NatureComms https://t.co/BriO7i6Cya

💻 @BBCNews https://t.co/ZuwhlKV19i

[1/7]

[Mit Shah @DoctorMitShah]

💡Features most predictive for CV age:

🖊️Vascular mechanics and structure
🖊️LV Strain

[3/7]

[Mit Shah @DoctorMitShah]

📜Overview:

🖥️ Studied 39,559 UK Biobank participants' CMR + ECG data with machine learning
💡Trained Catboost models for healthy CV ageing (n = 5066)
💡Predicted CV age in remaining sample (n = 34,147)
🔍 Analysed associations w/ risk factors + genetics

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[Mit Shah @DoctorMitShah]

It was an absolute honour to present my work as a YIA finalist at @escardio #escprev2023. Thanks to @DrDeclanORegan for his ongoing supervision, and congrats to the other finalists and winners.

[Mit Shah @DoctorMitShah]

@DrDeclanORegan Santa has very, very good taste in tipple!

[Mit Shah @DoctorMitShah]

@Tootingdaley @littlelady2004 @hannahsaywhaat @TicketmasterCS @Wimbledon Does your friend of a friend want to extend their good work to helping me and my dad? Have been hitting a brick wall for 2 weeks on end!

[Mit Shah @DoctorMitShah]

@AlmutasemS @MRC_LMS Fantastic talk and even I managed to follow! Wonderful images.

[Mit Shah @DoctorMitShah]

https://t.co/i70jeofkPG

https://t.co/HGM9vRxK1r