Doris Wang

Neurosurgeon, neuroscientist, human and dog mom, social media account manager for my dog. @NeurosurgUCSF

[Doris Wang @DorisWangLab]

@DenaDubal @margaretgadek @ScienceAdvances @BBParis1984 Congratulations Dena! Amazing work as always!!!

[Doris Wang @DorisWangLab]

@zixiao_yin Thank you Zixiao

[Doris Wang @DorisWangLab]

@SergeyStavisky @RithvikRamesh6 Thank you Sergey!

[Doris Wang @DorisWangLab]

Excited to share our latest preprint, led by @RithvikRamesh6!

https://t.co/cdQJid1oK0

See his excellent summary below ⬇️

[Rithvik Ramesh @RithvikRamesh6]

🚨NEW PREPRINT🚨

What if we could…
🏠 collect quality neural-behavioral data at home
🧠 identify naturalistic + personalized brain signatures of movement state
🚶🏽‍♂️use these biomarkers to drive real-time adaptive DBS for gait disorders

Our new work @DorisWangLab shows how! (1/8)

[Doris Wang @DorisWangLab]

@DenaDubal @RithvikRamesh6 Thanks Dena!

[Suzanne Tharin MD PhD @SpineTharin]

ICYMI…just realized this is available on YouTube: my presentation @CSRS_org a couple of years ago on research funding opportunities for #spine surgeons #neurosurgery #orthotwitter #mdphdlife #MedTwitter #Neuroscience https://t.co/a8v4xk1Lp0

[Doris Wang @DorisWangLab]

Thank you @WomenInNSGY for this invitation and opportunity to hear from these amazing neurosurgeon moms about their journey in parenthood!

[Women In Neurosurgery (WINS) @WomenInNSGY]

HAPPENING TOMORROW: Parenthood in #neurosurgery: challenges, choices, and triumphs. Join to hear experts share their journeys with family planning and work-life balance. Be part of the conversation—register now! @DorisWangLab @strahleMD @SarahMerrillMD @JacMacDonell

[Doris Wang @DorisWangLab]

Which may explain why PD patients who have excessive pallidal beta synchronization show hypometric weight shift during gait initiation.

Kudos to the entire team and lead author Jessica Bath for spearheading this study!

#Parkinsons #neurophysiology #neuroscience #dbs

[Doris Wang @DorisWangLab]

We are excited to share our preprint: Pallidal and motor cortical interactions determine gait initiation dynamics in Parkinson's disease https://t.co/66jseCRELW

[Doris Wang @DorisWangLab]

Our results provide evidence that synchronized premotor and motor cortical activities transiently couple with the globus pallidus to regulate the timing of postural responses, and local pallidal activity regulate the amplitude of postural changes during gait initiation.

[Mitra Afshari (she/her) @mitra_afshari]

Looking forward to Dr. Wang’s lecture TONIGHT on FUS in Movement Disorders for the TEAM virtual lecture series…what a treat to have this amazing neurosurgeon/researcher present on the cusp of reaching this milestone. Learn more about TEAM here:
https://t.co/HqdN1itqDB

[Doris Wang @DorisWangLab]

100 focused ultrasound procedures done!!! Thanks to the entire amazing team and our patients!

@NeurosurgUCSF @UCSFimaging @UCSFHospitals #hifu #fus #tremor

[Doris Wang @DorisWangLab]

Inspiring meeting about innovations and the future of DBS! Humbled to share the stage with giants and leaders of this field. Paris, je t’aime.
#DBS

[Doris Wang @DorisWangLab]

Kudos to postdoc Hamid Fekri Azgomi for leading this work, and to all the coauthors, and patients!

[Doris Wang @DorisWangLab]

We are excited to share our preprints: Modeling and Optimizing Deep Brain Stimulation to Enhance Gait in Parkinson's Disease: Personalized Treatment with Neurophysiological Insights https://t.co/yjXugGMZjl

[Doris Wang @DorisWangLab]

While DBS is effective at treating many appendicular symptoms of PD, its effects on gait are variable and less predictable. Why? Because we do not have a good understanding of neurophysiology of human gait and the impact of DBS on gait.

[Doris Wang @DorisWangLab]

And finally 3) we identified physiological signatures of improved gait with DBS. This work will provide a framework for how we use neurophysiology to optimize neuromodulation to treat motor (and potentially other) symptoms of Parkinson’s Disease

[Doris Wang @DorisWangLab]

Here in PD patients implanted with GPi DBS and cortical electrodes, we 1) developed a validated walking performance index to objectively measure gait metrics in PD patients 2) used a Gaussian Process Regressor to identify stimulation parameters that produce the best gait pattern