Henry Yang

Organoidist (trying to be) interested in using various tissues derived organoids with current focus on placenta organoids as microbial infection model.

[Henry Yang @Doublebrightly]

I'm super exciting to share my first (maybe also the last) 1st author paper during my postdoc training process with @scienceCC , of course with our amazing team work from @eleanor_semmes @ChristinaMegli @SalliePermar.

https://t.co/LFH25wnSQ1

[Henry Yang @Doublebrightly]

Check out this beautiful paper from our collaborator in UK reporting placental organoids can be derived from frozen cells isolated from term placenta.
Long-term culture and passaging of term trophoblast for the investigat... https://t.co/pwUOvgzOSR

[Henry Yang @Doublebrightly]

@TheLuftigLab Super creative idea !

[Henry Yang @Doublebrightly]

Duke Immunology rebirth as Integrative Immunobiology!!!

[Mary E. Klotman, MD @MaryEKlotman]

Stay tuned for my full conversation with @valdi001 tomorrow in my Friday Message. We discuss the new name of the Department of Integrative Immunobiology. Watch a clip from our conversation. 👇
@ImmunologyDuke

[DukeIntegrativeImmunobiology @ImmunologyDuke]

Trying hard to avoid entropy at our Departmental retreat

[Henry Yang @Doublebrightly]

@mariadinizcosta @RadioMovimento1 I'm proud of you, Maria.

[Henry Yang @Doublebrightly]

Had a really enjoyable days @ Santa Fe, NM , it was a harvest meeting, I'm so glade to see so many excellent scientists in Maternal- fetal interface field.

[Craig Bierle @CraigBierle]

Hats off to @LazearLab @DMAronoff and @scienceCC for organizing an outstanding @KeystoneSymp on Infections in Pregnancy. It was great to see everyone in Santa Fe this week; thank you for the opportunity to participate.

[Henry Yang @Doublebrightly]

Surprised with the truth about the shortage of the research in the field of reproductive health and disease.

[Raphael Valdivia @valdi001]

Meta-Research: The need for more research into reproductive health and disease https://t.co/554FdIWygF

[Henry Yang @Doublebrightly]

@caitehamele It seems like squeezed boiled 🥚😀

[Henry Yang @Doublebrightly]

Check out the video for trophoblast organoids stained with STB marker SDC-1(green) and actin (red) in our recently published paper.

[eLife - the journal @eLife]

Organoids developed from human placental tissue can be developed as models to study vertically transmitted microbial infections. https://t.co/54VrImx8t9

[Organoid News @organoidscience]

Check out this @iScience_CP paper! 👇

It presents a new air-liquid interface-#SkinOrganoid platform that may be a useful tool for modeling human #SkinDiseases and evaluating the efficacy of novel therapeutics.

Read more: https://t.co/WKQGM2tV75

[Duke Human Vaccine Institute @TheDHVI]

It's #NationalPostdocAppreciationWeek! We appreciate our Postdocs' significant contributions and dedication to science while advancing the mission of the Duke Human Vaccine Institute. We're excited to be a part of their journey!

[Henry Yang @Doublebrightly]

Still remember my PI @scienceCC mentioned this virus leads the epidemic in the pediatric group with a every several years cycle pattern. As a 2-y old kid parents, hope this year is not the climbing stage given that we have pretty got used to masking than ever.

[Matthew R. Vogt @VogtVirusLab]

As @kmess44 has been saying, lots of respiratory illness out there right now, lots of #EVD68. The @CDCgov released an official health advisory about this today (linked). All pediatric providers need high clinical suspicion for #AFM in next few months.
https://t.co/hgI11cBaji

[Henry Yang @Doublebrightly]

@SalliePermar @scienceCC @eleanor_semmes @ChristinaMegli Of course, I think there should be other innate immune components/factors involve in the protection endeavor.

[Henry Yang @Doublebrightly]

I'm super exciting to share my first (maybe also the last) 1st author paper during my postdoc training process with @scienceCC , of course with our amazing team work from @eleanor_semmes @ChristinaMegli @SalliePermar.

https://t.co/LFH25wnSQ1

[Henry Yang @Doublebrightly]

@SalliePermar @scienceCC @eleanor_semmes @ChristinaMegli Yes, I think we already have some answers about your question that we believe the Type 3 IFNs play an important role in preventing the spread of HCMV at the maternal-fetal interface by using the Organoids models, the details can be found in Fig4, Fig7 & 8.

[Henry Yang @Doublebrightly]

@Cornymel @scienceCC @eleanor_semmes @ChristinaMegli @SalliePermar Thanks! BTW, I happen to see Kane lab's first paper came out. It's a nice paper. Congrats and hope you guys have a smooth review process.

[Henry Yang @Doublebrightly]

@eleanor_semmes @scienceCC @ChristinaMegli @SalliePermar Yes, we will definitely work on HCMV using the Organoids model we developed.

[Henry Yang @Doublebrightly]

This is super cool! Then was wondering and curious what 🐢's hepatic Organoids can be or will be used for?

[Sydney Honold @sydney_honold5]

Participated in my first research symposium today with my poster on the derivation and characterization of the first turtle hepatic organoids! Huge thank you to everyone involved!🐢🧬

@AcademicChatter @ISU_GenMajors @ISUVetMed

[Henry Yang @Doublebrightly]

@scienceCC Thanks for your highly praise, my Prof! I'm afraid I can't make it to the end without your strong support! Looking back I really appreciate your decision moving to Duke, which is a super great decision that lets me access much more tissues to pursue the success of this project.

[Henry Yang @Doublebrightly]

Last point of this study I think it's worth to mentioned is we established the co-culture model of fetal derived Trophoblast organoids(TOs) and maternal decidua derived Decidual organoids, then use it to recapitulate viral infection at maternal-fetal interface in vivo.