Dougan Lab

Regulated proteolysis | N-degron | AAA+ machines | #Proteostasis views my own

[Dougan Lab @DouganLab]

Thermodynamic stabilization of substrate protein within the GroEL:ES chaperonin cage
https://t.co/V4py4yZyRY

[Dougan Lab @DouganLab]

Multimodal substrate recruitment enables CTLHMKLN1E3 ligase to target acetylated N-, C-, and internal degrons
https://t.co/XMyNAKDlo5

[ShorterLab @ShorterLab]

Mechanistic classification of the AAA superfamily with protein language models https://t.co/zmM2oIcqW6

[Dougan Lab @DouganLab]

Read this #preprint on @researchsquare: DPP9 triggers N-degron-mediated clearance of lysosome-escaped cathepsins to safeguard cells https://t.co/cZ3HKbWYzM

[Dougan Lab @DouganLab]

An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease | Science https://t.co/3d9OKq2SYP

[ShorterLab @ShorterLab]

Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation | PNAS https://t.co/qqJ7ENwQeM

[Guillaume Laconde @Glaconde34]

GID4-Recruiting PROTACs for BRD4 Degradation Overcome Resistance Driven by CRBN and VHL Deficiency | Journal of Medicinal Chemistry https://t.co/bP8cJm9uWT

[Dougan Lab @DouganLab]

Structural proteomics reveals that misfolded nascent proteins expose buried lysines for ubiquitination and rapid proteasomal degradation
https://t.co/27uL2u3EpZ

[Belgian Red Devils @BelRedDevils]

Overturn this. 🧏‍♂️ #USABEL

[Dougan Lab @DouganLab]

Stress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex | Nature Communications https://t.co/PaJXkavpeD

[Molecular Cell @MolecularCell]

Online Now: Design principles of a membrane-spanning ubiquitin ligase https://t.co/4Gqc287NpC

[Dougan Lab @DouganLab]

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation | PNAS https://t.co/ggOc8bSyIh

[Dougan Lab @DouganLab]

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry https://t.co/tRmNOf5auw

[Dougan Lab @DouganLab]

Chemical activation of mitophagy via the N-degron pathway alleviates mitochondrial neuropathies https://t.co/1X9CrevtK4

[Guillaume Laconde @Glaconde34]

Data-Driven Design of PROTAC Linkers to Improve PROTAC Cell Membrane Permeability | JACS Au https://t.co/0Ybh7kr1CI

[Dougan Lab @DouganLab]

Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry https://t.co/tRmNOf5auw

[Hema Chandra Kotamarthi @HemaKotamarthi]

Our recent work on mechanism of disassembly and reassembly of oligomeric proteins is now published in ACS Biochemistry.
https://t.co/swlKg7GMpg

[Dougan Lab @DouganLab]

CLIP-LUX: A Luminescent Split-Ubiquitin Assay Using ClpS-Mediated N-Degron Recognition for Detection of Protein-Protein Interactions in Mammalian Cells. https://t.co/q4dgRhSWrS

[Dougan Lab @DouganLab]

Elongation Factor Tu Acts as a Chaperone to Activate an Antibacterial RNase Toxin - https://t.co/VopfnlQgBo #ScholarAlerts

[Molecular Cell @MolecularCell]

Online Now: Mitochondria as sources and targets of cellular signaling https://t.co/LFadRnFIhD