Sandeep Palakodeti, MD MPH

Author, The Ultimate Asset: Physician, CEO & Founder @join_velocity ex- @harvardmed @mayoclinic

[Sandeep Palakodeti, MD MPH @DrDeepMD]

@sdixitmd Nothing more potent tbh

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Current AM stack:

50 g whey protein
10 g creatine
1 mg pinealon
8000 iU vit d3+k2
5mg tadalafil
500 mg NMN
600 mg NAC
1 g EPA/DHA
20 mg dihexa
B vitamin
Nattokinase
Aspirin

Roast me

[Sandeep Palakodeti, MD MPH @DrDeepMD]

@Metabohealth Haven’t started pooping blood yet

If you don’t know why I’m taking both, you should assume that means you have more study to do, not that I’m a dumbass!

[Sandeep Palakodeti, MD MPH @DrDeepMD]

@paul_ginart My ApoB is 90ish. Could be better. Working on my trigs

Nattokinase 12k fu daily

Haven’t done CCTA, that’s next but CAC zero

[Sandeep Palakodeti, MD MPH @DrDeepMD]

This has always been a crazy realization from the early chemistry days

We never really “touch” anything

Nothing really ever touches anything else

Every single atom is surrounded by an electron cloud that naturally repels other electron clouds, like two magnets

Life is weird

[Boşuna Tıklama @bosunatiklama]

Claude'un yeni yapay zeka modeli Fable 5.2, parmakların neden hiçbir zaman birbirine dokunamadığını görselleştirerek anlattı.

[Sandeep Palakodeti, MD MPH @DrDeepMD]

@NeilpDo keen insights! i saw the Q3 numbers, and you're totally right that this will be one of the only ways to protect shrinking margins. the power of the influencer reigns supreme

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Ummm

Nice

For him. And hims.

Different pressures and calculus at that level I guess

Not my fave move

[Hims House @himshouse]

$HIMS - ANDREW HUBERMAN BOARD SEAT DETAILS

Compensation: $50K cash + $250K equity annually

Advisory deal: $3.5M annually for 2 years ($7M total)

Podcast advertising: $5M annually for up to 3 years ($15M total) through Scicomm Media

Additional advertising: Up to $1M annually for optional short-form videos

Total potential commitment: $24M, excluding board compensation

Huberman is classified as a non-independent director due to commercial ties

[Sandeep Palakodeti, MD MPH @DrDeepMD]

@operationdanish Do you or would you use Hims? Why or why not?

[Pratik Patel @PratikxPatel]

A higher TG:HDL ratio is associated w/:
-Insulin resistance and hyperinsulinemia
-Increased visceral adiposity
-Greater TG lipoprotein burden
-A more atherogenic lipid profile
-Higher cardiometabolic risk

An IDEAL ratio profile would be <1.0 with TG well below 100 (below 50 is superb) and HDL above 50

It (and any lipid marker/ratio) should NEVER be used in isolation alone (esp with no context)

It should be used in conjunction with other cardiovascular/lipid markers can give you a proper view of current health, risk profile, and what areas/levers need to be addressed

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Once longer term data play out, this is much more likely to ⬇️ MACE and ACM vs just focusing on LDL and I guess now Lp(a)

Getting fasting Trigs &lt; 100 should be everyone’s goal, if not &lt;50

Trig/HDL ratio &lt; 2 good, &lt; 1 is excellent

TG 150 / HDL 50 = 3 ❌
TG 50 / HDL 100 = 0.5 ✅

[Ethan J. Weiss @ethanjweiss]

Fun to be in the room for this…

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Eudomonia summit was a who’s who of the health and wellness space

I’ll have some deeper reflections soon, but always fun to meet in real life!

@paulsaladinomd

[Sandeep Palakodeti, MD MPH @DrDeepMD]

@BenSettle lol which one is which???

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Oof

Curious findings here

Lowering Lp(a) - at least pharmacologically - had…..

Zero impact on the outcomes that mattered

It moved the biomarker but did nothing to prevent MACE or ACM

Much deeper story here

[Marios Georgakis @MariosGeorgakis]

Lp(a)-lowering had absolutely zero effect on cardiovascular events in HORIZON.

Neither in Lp(a) >70 mg/dL, nor >90 mg/dL - no matter how the data were analyzed.

Big bust. Favors the most pessimistic scenario that Lp(a)-lowering is very unlikely to move the needle, at least in secondary prevention.

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Interesting. Is it unique to this admin or has it been going for years?
When you say regulatory capture, does that mean the large incumbents like pharma who run giant multibillion dollar trials, have captured agencies like NIH and FDA through donations, leadership carousel, etc and want to stifle this kind of decentralized research as it threatens their business model? Basically making it harder for any new entrant to breakthrough

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Btw some of you have texted me asking this haha

Abud deffff mogs me on girth, he’s dense as hell

Despite the pic, I think I got him on height by a bit tho 😂

Not all of us were blessed w myostatin deficiencies!

[Sandeep Palakodeti, MD MPH @DrDeepMD]

We finally made it happen yall

This space is finally maturing

We’re starting to see the right minds all come together, and the charlatans pushed out

Optimistic for the future!
@AbudBakri

[Sandeep Palakodeti, MD MPH @DrDeepMD]

A maturing is happening

Little by little

It’s not incremental change to the existing system that’s going to make quantum leaps in the health of our people and populations

The real maturation is realizing we can’t build within the existing rails. We are evolving the infrastructure, the depth of thinking, and the community that supports a PARALLEL system

This is the way new institutions and industries will be built in the future. Look at SpaceX, crypto, influencer marketing etc. All grew up and matured alongside the system that they will eventually replace, playing by some rules, while challenging many others

So too will it go in healthcare. And that always starts with the right people, with the right conviction, coming together, dedicating themselves to lasting change and leaving a legacy bigger than themselves

We all deserve better. My family deserves better. We must fight to bring about the change we want to see in the world

It’s time

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Interesting discussion w @thegarybrecka and @DavidPerlmutter on the very essence of memories

It’s obviously not amyloid plaque that tells the whole story, that is stupid

We see examples like this where memories are clearly there. Just deeply locked away

Beautiful and haunting

[Sandeep Palakodeti, MD MPH @DrDeepMD]

Huberman just said on large public stage that the harshest and nastiest comments he sees across his entire platform are women listeners trashing his women guests 🤷🏾‍♂️

[Sandeep Palakodeti, MD MPH @DrDeepMD]

“You can’t put the genie back in the bottle”

On sunlight, peptides, n of 1 studies, etc

@hubermanlab

It’s a bold new time! We are so early