Dr Jeremy William

MBBS BMedSc FRACP
Cardiologist & Electrophysiology Fellow 🫀⚡️
Toronto General Hospital and Alfred Health
First author on the Syncope Stopper Randomized Trial

[Dr Jeremy William @DrJeremyWilliam]

Proud to present Syncope-Stopper RCT at #ESC2026 Hot Lines! 🫀⚡️

In high-risk syncope with DROP score≥2, upfront pacing led to:
✅ Fewer syncopal events: 11% vs 22%
✅ Fewer hospitalizations: 36.4% vs 63.4%
✅ Fewer ED visits: 24.2% vs 40.6%

@Vosko1984 @drjohnm @peterkistler3

[Dr Jeremy William @DrJeremyWilliam]

@DrSouvikKDas Amazing work Souvik! Good luck for the presentation

[Dr Jeremy William @DrJeremyWilliam]

@HiraaliCardio MR with Coandă effect

[Dr Jeremy William @DrJeremyWilliam]

@WALangProf Important to remember that 'standard care' often entails expensive downstream testing, most notably loop recorders themselves are quite costly.

Upfront pacing in the previous SPRITELY study was overall more cost effective than loop recorders

https://t.co/7IUei1pmVD

[Dr Jeremy William @DrJeremyWilliam]

Proud to present Syncope-Stopper RCT at #ESC2026 Hot Lines! 🫀⚡️

In high-risk syncope with DROP score≥2, upfront pacing led to:
✅ Fewer syncopal events: 11% vs 22%
✅ Fewer hospitalizations: 36.4% vs 63.4%
✅ Fewer ED visits: 24.2% vs 40.6%

@Vosko1984 @drjohnm @peterkistler3

[Dr Jeremy William @DrJeremyWilliam]

💡Key Takeaway: Upfront pacing improves clinical outcomes compared to standard care in patients with unexplained syncope and high-risk DROP score ≥2

[Dr Jeremy William @DrJeremyWilliam]

Study design:
👥 Unexplained syncope with DROP score ≥2
🔬 Randomized to upfront pacing vs standard care (ILRs and Holters)

DROP score: 1 point each for
🇩istal conduction disease (BBB/fascicular block)
🇷elated syncope triggers absent
🇴lder age >65 years
🇵R interval > 200ms

[Dr Jeremy William @DrJeremyWilliam]

@DrSouvikKDas @Dr_RobAnderson @DrGeoffLee @JonKalmanEP Looks amazing, well done!

[Souvik Kumar Das @DrSouvikKDas]

Our comprehensive review is now available at JACC EP!
Left Ventricular Summit Arrhythmias: State-of-the-Art Review of Anatomy, Mapping, and Ablation Strategies | JACC: Clinical Electrophysiology https://t.co/ouWK2KwxcP
#eppeeps #vt @Dr_RobAnderson @DrGeoffLee @JonKalmanEP