To stay ahead of cancer, we need to understand how tumor cells adapt. This @theNCI study reveals how environmental stress can drive heritable changes in gene expression, offering new insights into one of cancer’s greatest challenges: drug resistance. https://t.co/moyvsyouMc
Stress controls epigenetic inheritance!
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance and cancer👉https://t.co/Wf8y1HjHEX
Stress controls epigenetic inheritance!
A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance and cancer👉https://t.co/Wf8y1HjHEX
Congratulations again Sahana. Very Happy and proud of you. Looking forward to seeing many more accomplishments come your way. Very best for the new start!
Thrilled to share that I’ve joined @TIFRH_buzz as an Assistant Professor! Deeply grateful to my mentors (esp @grewalsh and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!
Thrilled to share that I’ve joined @TIFRH_buzz as an Assistant Professor! Deeply grateful to my mentors (esp @grewalsh and KN Balaji), colleagues, friends, family & EVERYONE who made this possible. Excited to explore Epigenetics & the 3D Genome with the brilliant minds in India!
🔬 Decoding Silencing: How Heterochromatin Transcribes to Silence Itself!
🧬Our latest research reveals how a pioneer transcription factor-like complex PhpC/NF-Y infiltrates repressive heterochromatin, generating transcripts with hidden introns that kickstart RNAi-mediated heterochromatin formation
https://t.co/LMzKtyhlPu
📢ACCESS DENIED!!
Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited?
Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance
#epigenetics #heterochromatin #histones #chromatin
Congratulations to @rakesh_k_sahu and other lab members!
https://t.co/Q6ebM1zBBR
📢ACCESS DENIED!!
Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited?
Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance
#epigenetics #heterochromatin #histones #chromatin
Congratulations to @rakesh_k_sahu and other lab members!
https://t.co/Q6ebM1zBBR
📢Job Opening COMPUTATIONAL STAFF SCIENTIST🌟
The Laboratory of Biochemistry and Molecular Biology (LBMB) at NIH is seeking a Computational Staff Scientist to analyze transcriptional and post-transcriptional processes in eukaryotes. Full job ad here 👉https://t.co/CqeGSdoJLH
📢An elegant dance between replication and histone retention for epigenetic inheritance!🥳Our new work shows that heterochromatin domains are specialized replication zones that preserve parental modified histones to ensure self-templated chromatin assembly https://t.co/JWXeySNvBC
Congratulations @grewalsh@pnathanailidou@holla_sahana for this amazing work and insight on how specialized replication zones helps preserve heterochromatin!
📢An elegant dance between replication and histone retention for epigenetic inheritance!🥳Our new work shows that heterochromatin domains are specialized replication zones that preserve parental modified histones to ensure self-templated chromatin assembly https://t.co/JWXeySNvBC
📢 Exciting news! 🎉 Our recent paper is now published, showcasing the crucial role of the cysteine-rich domain in CENP-A chaperone Scm3/HJURP for centromere targeting and kinetochore integrity! https://t.co/CYVSUuDsyR🥳
Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3
Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.
Congratulations, India🇮🇳!
#Chandrayaan_3#Ch3