Patroula Nathanailidou

Biologist, PhD | Postdoctoral Fellow | Laboratory of Biochemistry and Molecular Biology | ΝCI | NIH

[Patroula Nathanailidou @pnathanailidou]

Super excited to share our cool story highlighting heterochromatin domains as specialized replication units evolved to ensure epigenetic inheritance! Shout out to @grewalsh and all the coauthors for bringing this work to fruition!!🥳🎉🎉Check it out: https://t.co/S5Ye24QpvL

[Shiv Grewal @grewalsh]

📢An elegant dance between replication and histone retention for epigenetic inheritance!🥳Our new work shows that heterochromatin domains are specialized replication zones that preserve parental modified histones to ensure self-templated chromatin assembly https://t.co/JWXeySNvBC

[Ilias Skeparnias @IliasSkeparnias]

Happy to be part of this work, now out in @NatureComms! Our new cryo-EM structures capture the full catalytic cycle of RNase P, revealing how a trans-acting ribozyme operates.
A step toward understanding ancient #RNA-based catalysis 👇

[Nibal Badra @Nibal_Badra]

Happy to share the results from my PhD thesis, in which we uncovered a function for FANCD2 on maintaining fork stability upon re-replication, now out in Nat. Commun.

📖 Read the full story here: 

https://t.co/0vL2D0Jlcc

Thanks to everyone who supported me along the way!

[Shiv Grewal @grewalsh]

Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance and cancer👉https://t.co/Wf8y1HjHEX

[Patroula Nathanailidou @pnathanailidou]

@holla_sahana @TIFRH_buzz @grewalsh Huge congratulations Sahana! Brilliant days are coming! All the best!

[Jinwei Zhang Lab @jinweizhang]

How sturdy are base pairs near the ends of #RNA hairpins? Perhaps not as stable as one might think, esp. when there are bulges near and far. Led by @CharlesBNader in @NatureComms, we describe complete structures of #HIV #TAR RNA and its dynamic excursions.https://t.co/2vvKK1CQaC

[Robin Sebastian @rob_seb_]

Thrilled to share our latest work in @Nature! We show how cancer cells navigate DNA replication despite DNA damage, revealing new insights into genome stability. Huge thanks to my incredible collaborators! Check it out here: https://t.co/XveTox3LEb

[Manjit Kumar Srivastav @SrivastavManjit]

📢New Publication Alert📷 The PhpC/NF-Y, a pioneer like TF complex, accesses heterochromatin to drive the transcription of a cryptic intron-containing transcript to initiate silencing. A big thank you to
@grewalsh and all the amazing coauthors for their invaluable contributions!

[Patroula Nathanailidou @pnathanailidou]

A must read for the New Year!!Glad to be part of it!Congratulations to all the authors and friends!!🍾🍾🍾

[Jinwei Zhang Lab @jinweizhang]

Glad to be part of two new @nature papers led by @Degenhardt_MFS
@TzaiYun @YunXingWangLab @IliasSkeparnias, which use AFM images and neural networks to map complex #RNA conformations and dynamics in solution. A Herculean effort! https://t.co/5ZoVv6qI4U. & https://t.co/DerrHXFWU8.

[Ilias Skeparnias @IliasSkeparnias]

Thrilled to be part of this amazing collaboration exploring the conformational space and structural dynamics of heterogeneous RNAs - @TzaiYun @Degenhardt_MFS @YunXingWangLab @jinweizhang. Excited to see our work published in @Nature just in time for the holidays!

[Ilias Skeparnias @IliasSkeparnias]

Excited to see our work featured in this month’s @NatureSMB issue! Our two studies uncover how lncRNAs fold to engage processing enzymes, drive their maturation, and generate new noncoding RNAs. @jinweizhang #tRNAmimicry #MALAT1 #NEAT1 #mascRNA #menRNA

[Jinwei Zhang Lab @jinweizhang]

Thank you @sarakosman @NatureSMB for featuring our two studies on #MALAT1 & #NEAT1 on the Nov cover! Led by @IliasSkeparnias we describe how #lncRNA partially mimic #tRNA structure for their maturation and #mascRNA #menRNA biogenesis. https://t.co/cK0MNirJMT

[Panos Galanos @p_galanos]

🚀 #Postdoc Opportunity! 🚀 Join my lab @UniSouthDenmark in the Translational Cancer Hub initiative. Dive into cellular #senescence & its impact on cancer progression & therapy resistance! Apply here 👇
https://t.co/1qCKSZuh6T

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[Shiv Grewal @grewalsh]

Hurry! The deadline to register for the exciting symposium on "Histone Modifications and Chromosome Structures" is quickly approaching—this Friday, October 4, 2024. This symposium featuring talks by 25 renowned scientists is free to attend. To secure your spot, please visit: https://t.co/r1vNDFHkhB

[Astrid Haase @haase_astrid]

A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals: Cell Reports https://t.co/IbhNHiF1Oo

[Marianna Rapsomaniki @marianna_raps]

🥳 Incredibly proud and excited to share our latest work @unil @CHUVLausanne, now out in @NatMachIntell!

Led by the brilliant @pushpak_pati, we show how #GenerativeAI can be used to synthesize multiplexed IHC images for several markers from a single H&E image.

Details 🧵👇:

[Molecular Cell @MolecularCell]

Heterochromatin: Hiding from the remodeling machines https://t.co/psbnpYIAg7

[Shiv Grewal @grewalsh]

🎉 Exciting Announcement! 🎉

“Histone Modifications and Chromatin Structure Symposium”

🗓️ Dates: October 17-18, 2024
📍 Location: National Institutes of Health, Bethesda, Maryland

The NCI Center of Excellence in Chromosome Biology is delighted to invite you to our upcoming symposium. This symposium honors the legacies of Dr. C. David Allis and Dr. Gary Felsenfeld, pioneers in the study of chromatin and gene expression. Presentations from 25 renowned scientists. For more details and to register, visit: https://t.co/U2k3eG0aDQ

[Science News @SciencNews]

Scientists should get paid for thinking time @Nature

#PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science