Lisa

Quietly radical | Founder/CEO @istesso | The first oral regenerative medicines

[Lisa @DrugDiscoverer]

As we age we heal more slowly. A key challenge of regenerative medicine is to promote and regulate the repair and maintenance of tissues and organ systems to overcome progressive decline seen with disease and ageing.

[Lisa @DrugDiscoverer]

@elonmusk To achieve this we need to solve the key problem of maintain human biology in a low gravity, high (cellular) stress environment without multiplexing existing (earth- and disease- directed) approaches. Something adaptive, functional in muscle, bone and inflammation….

[Lisa @DrugDiscoverer]

@grok @diweixia @elonmusk Oral regenerative medicines that build tissue resilience!

[Lisa @DrugDiscoverer]

He says he’s planning it but X-prize requires a 6month on, and 6 month off regimen. That would mean completing a Phase II and 2 species GLP tox, and GMP suitable to support that dosing duration before the start timeframe for the finals prize if it’s an NCE. Not impossible, but tight.

[Lisa @DrugDiscoverer]

Actually, aging is an adaptive homeostasis problem.

[Elon Musk @elonmusk]

@m_goes_distance Always has been

[Lisa @DrugDiscoverer]

@realNathanCheng Oral small molecules that repair and regenerate in situ is the easiest and most scalable. But I’m biased!

[Lisa @DrugDiscoverer]

100%. The longer the response is prolonged the more resilience declines. Adaptation and ability to resolve stress responses is critical.

[Madam Mitochondria @Madam_Mito]

Instead of asking “What damage causes aging?”

Researchers must ask, “Why do young organisms recover from stress while old organisms cannot?”

[Lisa @DrugDiscoverer]

Except that biology is adaptive. The ability to flux is a feature. Not a bug.

[Lisa @DrugDiscoverer]

Except that biology is adaptive. The ability to flux is a feature. Not a bug.

[David Sinclair @davidasinclair]

The more stable the system the slower the aging

[Lisa @DrugDiscoverer]

@ideapharma Wow! This is stunning 🤩

[Lisa @DrugDiscoverer]

@juliankissa Me. Massive impact from a tiny change.

[Lisa @DrugDiscoverer]

@_tenZdhon_ Go easy on yourself. Bio is hard.

[Lisa @DrugDiscoverer]

@Madam_Mito Can’t like this enough.

[Lisa @DrugDiscoverer]

The field is hooked on the idea of reprogramming/rejuvenation, assuming this will fix everything else. The trouble is that mitochondrial function drives epigenetic change and fate selection (more than vice versa), and orchestrates tissue level repair, which is what the ‘solution’ actually requires 🤷‍♀️

[Lisa @DrugDiscoverer]

@AdamDraper @BoostVC This is actually achievable with chemistry therapies/oral small molecules.

[Lisa @DrugDiscoverer]

Full press release here → https://t.co/zq3OBlkAy0

[Lisa @DrugDiscoverer]

Very excited to share some new Istesso data today. Our lead oral regenerative medicine leramistat has shown it can restore muscle quality and function in aged mice to levels beyond those of young healthy animals. The data will be presented at the World Congress on Aging & Geriatrics in September. Thread 👇🏾 #Sarcopenia #RegenerativeMedicine

[Lisa @DrugDiscoverer]

Muscle function, measured by grip strength, is one of the strongest predictors of overall health, independence and survival. These data are really striking: leramistat drove quality and function beyond that of younger animals at baseline.

Proud of my team for consistently delivering scientific wow moments

[Lisa @DrugDiscoverer]

@StephNass VC map