This is insane.
Scientists just built the world's first fully synthetic cells that can complete a full cellular life cycle.
"Researchers just created SpudCells, artificial cells assembled entirely from non-living components that can take up nutrients, grow, replicate their DNA and divide into daughter cells."
"According to the researchers, SpudCells consist of about 150-200 molecular components, absorb nutrients, grow, and typically persist for about 5 generations. They are far simpler than natural cells, which contain millions to billions of molecules."
"Unlike previous synthetic organisms created by modifying existing cells, SpudCells were built from scratch using lipid membranes, synthetic DNA, ribosomes, enzymes, and other purified biomolecules, marking a major milestone toward programmable synthetic life."
If we can design cells the way we design software today, the future could bring programmable living systems that manufacture medicines, clean pollution, capture carbon, repair damaged tissues and accelerate biotechnology in ways that seem almost unimaginable today.
This feels like small but important step toward an era where biology becomes an engineering discipline.
On her way out, @TulsiGabbard dropped bombshell documents proving Dr. Fauci colluded with a politicized intel community to bury the lab-leak truth and lie to Congress. I've referred him to the DOJ multiple times for prosecution.
The evidence keeps mounting, but more will be coming soon.
@mert The hate is about several things including: Crushing unions, supporting right wing and racist political parties in Europe, supporting the orange dude and making heil Hitler gestures to name a few.
Two days ago, something happened that most of the world still doesn't know about.
A human being received the first therapy in history designed to reverse cellular aging inside their body. Not slow it down. Not manage the symptoms. Actually reset the biological clock at the cellular level.
@lifebiosciences — co-founded by Harvard geneticist @davidasinclair — announced on June 9 that the first patient was dosed in their Phase 1 clinical trial of ER-100.
Let me explain what this actually is, because the implications extend far beyond the eye they're treating.
Your DNA is mostly intact throughout your life. Think of it as hardware. What degrades is the epigenome — the layer of chemical instructions that tells your genes what to do and when. Over decades, those instructions get corrupted. Genes that should be active go silent. Genes that should be silent activate. Cells lose their identity and function. We call this aging.
ER-100 uses three transcription factors — OCT4, SOX2, and KLF4 — to perform a partial epigenetic reset. These are the same factors that can reprogram any adult cell back into a stem cell. But they're not going that far. They're doing just enough to make damaged cells function like younger versions of themselves — without losing their identity.
The delivery is elegant. A one-time injection into the eye. An oral pill acts as an on/off switch — doctors control exactly how long the reprogramming lasts. If anything goes wrong, they turn it off.
This didn't come from nowhere.
In 2020, Sinclair's team restored vision in old mice and mice with glaucoma using this approach. The paper made the cover of Nature. They moved to monkeys with optic nerve damage — and successfully restored function with no major safety issues. Now, two days ago: the first human.
The trial is targeting glaucoma and NAION — a sudden "stroke of the eye" that causes devastating vision loss. Current treatments for both can only slow progression. Nothing reverses the damage. This therapy aims to regenerate damaged optic nerve cells by making them young again.
As a cardiologist, here's why this keeps me up at night — in the best possible way.
The eye is a safe, measurable starting point. But the platform technology isn't limited to the eye. If partial epigenetic reprogramming works safely in optic nerve cells, the same approach could theoretically be adapted for the brain, the spinal cord, the heart, the liver, the kidneys — any organ where cells lose function with age.
We're not testing whether we can treat one disease. We're testing whether we can treat aging itself as a reversible biological process.
For my entire career, cardiology has been magnificent at managing the downstream consequences of aging: high blood pressure, plaque buildup, heart failure, arrhythmias, stiffened arteries. We prescribe statins, antihypertensives, anticoagulants, and devices to manage what time does to the cardiovascular system. We're getting better every year.
But what if the cells themselves could be reset? What if the cardiac muscle cells that lose contractile function with age could be epigenetically restored? What if the endothelial cells lining sixty thousand miles of blood vessels could be made to behave like they did decades earlier?
That's not in a trial yet. But the foundational technology just entered a human body for the first time. And the companies racing in this space — Life Biosciences, Altos Labs, NewLimit — are backed by billions of dollars and some of the best scientists alive.
Essential caveats — because I'm a physician, not a hype man.
This is Phase 1. Roughly 18 patients. The primary goal is safety: does this cause harm? Is it tolerable? Efficacy data will come later. Many promising therapies have failed in the gap between animal models and human reality. Gene therapy carries risks — immune reactions, off-target effects, unintended cellular behavior. The oral on/off switch is a critical safety feature, but this is still the earliest possible stage of testing.
No one is reversing aging tomorrow. No one is living to 200 next year.
But a line was crossed two days ago that cannot be uncrossed.
For the first time in human history, someone received a therapy specifically designed to make damaged cells young again inside a living person. From impossible in theory to proven in mice to tested in monkeys to injected into a human being — in six years.
I've spent twenty years treating the consequences of aging. I've held hearts that were failing because time had degraded the cells beyond recovery. I've watched patients lose vision, cognition, mobility, and independence — and told them there was nothing I could do to reverse what time had taken.
This week, the conversation began to change.
Gene editing to permanently lower cholesterol. Personalized mRNA vaccines to hunt cancer. GLP-1 drugs rewiring metabolism, reducing depression, and cutting cancer metastasis. And now — partial cellular reprogramming to reverse aging at the epigenetic level.
I said months ago on this platform that our children may live past 100 — not frail, but strong and vibrant.
The evidence keeps building that this isn't optimism.
It's a timeline.
“AND YOU STILL DARE TO OPEN YOUR MOUTH…”
Sasha Legerman: This is too accurate not to share.
This Australian’s response to Trump’s rant that “NATO does nothing for America” is absolutely devastating:
“Mate. You run a country where 600,000 homeless people will sleep on the streets tonight.
A country where 40% of adults can’t cover a $400 emergency without borrowing money.
A country where insulin costs more than a car payment, and people ration it just to stay alive.
A country where medical debt is the number one cause of bankruptcy.
A country where women die in hospital parking lots because doctors are too afraid of abortion laws to treat miscarriages.
You imprison more of your own citizens than any country on Earth.
More than China. More than Russia. More than North Korea.
In the land of the free, 2 million people sit in cages, and a quarter of them haven’t even been convicted of anything.
They’re simply too poor to afford bail.
Your life expectancy is declining. You’re the only developed nation where that’s happening.
Your infant mortality rate is worse than Cuba’s.
Your children practice active shooter drills between math and English classes while you sell defense stocks to your friends.
Your minimum wage hasn’t changed in 15 years.
Your teachers work two jobs, your veterans sleep under bridges, and you just spent a trillion dollars flattening a country that never attacked you.
And now a convicted criminal — found liable for sexual abuse, defending a pedophile, sleeping with a porn star, and running the biggest dumpster-fire campaign since the Taliban — is thanking you for yet another disaster.
And you call Greenland badly governed?
Greenland has universal healthcare. Free education. One of the lowest incarceration rates in the world.
Nobody there goes bankrupt because they got sick. Nobody dies in a waiting room because insurance refused treatment.
‘NATO wasn’t there when we needed them.’
When exactly was that, champ?
September 11?
Because NATO invoked Article 5 for the first and only time in history FOR YOU.
Soldiers from dozens of countries deployed, fought, bled, and died in Afghanistan FOR YOU.
Australia wasn’t even in NATO, and we still showed up. For twenty years.
And then you left at 2 a.m. without telling anyone and left everybody else to clean up the mess.
You don’t care that a great nation is being terrorized by your friend, and you haven’t shown it a single ounce of sympathy.
So maybe before calling other countries badly governed, take a look at your own backyard, you aluminum siding salesman with a spray tan.
The only thing badly managed in this picture is your damn mouth.
And you still dare to lecture the rest of the world?”
It’s not an antisemitic conspiracy theory when a foreign lobby openly brags that they bought two congressional seats with candidates who will be loyal to Israel.
Trump is not Xi, he's not Putin, he's not Stalin.
He doesn't have the patience, the energy, or the organizational discipline to build a true infrastructure of authoritarianism.
And he's up against a system that's worked for 250 years and isn't going down without a fight.
So here's my prediction: by the end of 2028 he becomes largely irrelevant.
-He'll make billions of $$$.
-He'll pardon himself.
-He'll pardon the family, pardon everyone in his orbit who's been doing the insider trading, the meme coins, the crypto nonsense, the corruption.
The one scenario that changes everything is if he dies in office.
God forbid — I'm not wishing that on anyone.
But if Vance takes over and eventually gets ousted, the family is in serious trouble.
You can't hide multi-billion dollar corruption without a sitting president to issue the pardons.
That's the whole architecture of the exit strategy and I think he's thought about it more carefully than people realize.
🇺🇸BREAKING: Someone placed a $920 million crude oil short at 3:40 AM.
70 minutes later Axios reported the US and Iran were close to a deal.
Oil dropped 12%.
The trade made $125 million in profit.
Minutes after that Iran launched the “Persian Gulf Strait Authority” and oil surged 8%.
$760 million placed before Trump’s last announcement.
$920 million placed before this one.
Every major announcement in this war has been front-run by someone who knew it was coming.
What kind of war is this?
This is more like a trading desk with an army.
Never stop connecting the dots.