West Laboratory

The West lab identifies pathogenic mechanisms underlying neurological diseases like Parkinson’s to develop new therapeutics that block disease progression

[Duke Pharmacology & Cancer Biology Department @Duke_PCB]

Work led by Arpine Sokratian in Andy West's lab unveils the structural underpinnings of alpha-synuclein pathogenicity: Mouse alpha-synuclein fibrils display unique features compared to humans, impacting disease models. More here: https://t.co/Im7IpdIU5C

[The Science of Parkinson's @ScienceofPD]

Interesting: @DukeWestLab @LashuelLab & collaborators report the first atomic structure of mouse α-synuclein fibrils, but find altered packing arrangements,⬇️hydrophobicity, &⬆️fragmentation sensitivity & weak immunological responses (vs human a-syn)
https://t.co/TZ1MKSFOrM

[The Science of Parkinson's @ScienceofPD]

New paper from @DukeWestLab et al present an ultra-sensitive version of a SiMOA (single-molecule array assay) for measures of LRRK2 kinase activity in serum linking #Parkinsons severity to peripheral inflam.; Accurate measures of pT73-Rab10 to total Rab10
https://t.co/os1M7YGfue

[JCI insight @JCI_insight]

#Cover: Gut mucosal cells transfer α-synuclein to the vagus nerve: https://t.co/U6abFKMpAC

The image shows α-synuclein (red) emerging from an enteroendocrine cell (green) onto a vagal neuron (turquoise).

@DukeHealth
#Gastroenterology #Neuroscience

[The Science of Parkinson's @ScienceofPD]

New research from @DukeWestLab & collaborators reports that anionic nanoplastic contaminants potently precipitate the formation & propagation of #Parkinsons-associated α-synuclein protein fibrils, through a high-affinity interaction NAC domains in α-syn
https://t.co/VWjfiIlmdD

[West Laboratory @DukeWestLab]

Nanoplastics Create an Environment for Parkinson’s To Develop, Study Suggests | Technology Networks https://t.co/K16okH5rz7

[West Laboratory @DukeWestLab]

Congrats to Amber!!, Our amazing undergrad researcher off to begin her career in medicine

[West Laboratory @DukeWestLab]

Congrats to Jon Lin!!, Honors undergraduate researcher who will be starting his program in data science in a few weeks @NCState

[West Laboratory @DukeWestLab]

Recent Duke Neuroscience honors Graduate, Deney Li, researcher extraordinar, will be heading our @MichaelJFoxOrg biomarker research project as a post-bacc! So happy she can stay on!

[West Laboratory @DukeWestLab]

Our undergrad researcher Grace, headed for @UW_MSTP , go get em!

[West Laboratory @DukeWestLab]

Congrats to Nicole!!, our post-doc headed to @VividionRx shake up the Early Discovery program!

[West Laboratory @DukeWestLab]

Congratulations to Zhiyong!!, Our famous K99/R00 awardee and incoming tenure track Assistant Professor in Cell Biology, #UABSOM #GoBLAZERS

[West Laboratory @DukeWestLab]

Shoutout to our grad student Samuel Strader publishing an excellent review!
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease https://t.co/57shSgVYLt

[West Laboratory @DukeWestLab]

Congrats to the West Lab 2023 Graduates!! Moving on is bittersweet for us, but what a great job in the lab, you will be missed 🥲

[David Standaert MD, PhD @DavidStandaert]

Interesting new commentary from West and Schwarzschild on LRRK2 inhibitors for PD and their journey through the pharma "Valley of Death." #LRRK2 #Parkinsons @DukeWestLab
https://t.co/Y9aUgubmsy

[West Laboratory @DukeWestLab]

@biorxivpreprint Rab12 activation controls pT73-Rab10 levels

[bioRxiv @biorxivpreprint]

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase https://t.co/AtjpKxJGJr #bioRxiv

[ASAPLiddleTeam @ASAPLiddleTeam]

@ASAP_Research @AsapLiddle retreat wrapped up today…what great science was discussed 🤓😍!!!

[Duke Research & Innovation @dukeresearch]

College life in a research lab: two students @DukeNeuro weigh in on how they got here, what they're learning and where they hope to go https://t.co/Ua9JuKkVpe @DukeWestLab

[West Laboratory @DukeWestLab]

Celebrating Halloween at the lab 🧟🧚🏻‍♂️🧙