Elena Mandrou

PhD graduate in Cancer Sciences

FLIM | G-proteins & their GPCRs | Cancer cell migration & self-generated gradients

[Elena Mandrou @EMandrou]

My first (and probably last) first-author paper published during my graduation ceremony!

Couldn't have asked for better timing!

Check it out if you're into FLIM-FRET and G protein signalling: https://t.co/DRquOoyRJ9 #mdpicells via @Cells_MDPI

[Science Immunology @SciImmunology]

Dendritic cells can “self-shape” the chemotactic gradients that help them transport antigens to lymph nodes, finds a new live imaging study from @Sixt_Lab @EdouardHannezo.

📄: https://t.co/g6ZCFCfCQW
Focus by @hannahdonnelly_ @EMandrou @robinsall: https://t.co/1G1xcJdKe4

[Elena Mandrou @EMandrou]

@BakalLabICR Posting that many images on Twitter would be quite the feat! I've seen many similar FOVs in my samples - just picked that one as an example. In any case, maybe the 1st Q to ask could be "does cell size matter?" & "what effect does it have?" when comparing WT vs disease

[Elena Mandrou @EMandrou]

@BakalLabICR I don't know if cancer cells care what size they are. At least it doesn't seem to be the case with the PDAC cell line I'm using. 3 different categories of size in 1 image:

[Robert Insall @robinsall]

New chemotaxis preprint!

Repulsion of cells by a chemical - 'chemorepulsion' - caused by competition with other attractants, not by direct repulsion.

The most remarkable result is at the end (movie 5).

1/n

https://t.co/rX4q1wcACf

[Elena Mandrou @EMandrou]

Many thanks to all the co-authors - it's been a pleasure working with you to organise the Physics of Life workshop and writing this article.

And a big thank you to @morenorse for his beautiful sketchnotes! (3/3)

[Elena Mandrou @EMandrou]

Really happy to see this article published @iScience_CP

"Working at the interface of physics and biology: An early career researcher perspective"

Among other things, discussing challenges of interdisciplinary projects AND lessons learned... (1/3)

https://t.co/L11Oa8zPrF

[Elena Mandrou @EMandrou]

...based on our experience working in @PhysicsofLifeUK @EPSRC projects, but relevant to all interdisciplinary projects (2/3)

[Elena Mandrou @EMandrou]

@ScotRail So the signalling problem is after westerton?

[Elena Mandrou @EMandrou]

@ScotRail Are there no trains to westerton? They all terminate at hyndland. How do we get to westerton?

[Elena Mandrou @EMandrou]

@AnhHLe2702 I'm really not sure. It just reminded me of what one sheet of the scoby looks like. Regardless, I wouldn't consume it. I say bin it/kill it with fire 🔥

[Elena Mandrou @EMandrou]

@ml_vieri 🕸️

[Robert Insall @robinsall]

So - we wrote a review!
Here's a free link.

#chemotaxis
#selfgeneratedgradients
#cellmotility
#computationalmodelling
#devbio
#immunology

https://t.co/0yFyvPR4j9

[Elena Mandrou @EMandrou]

@Femtoscopist @nano_nick @femto_mccoy @MIC_KCL @augustineaniv What is #DiscoFLIM ?

[Elena Mandrou @EMandrou]

@drmartens am I meant to break in the shoes, or are the shoes meant to break me in?

[Elena Mandrou @EMandrou]

@joachimgoedhart @J_Cell_Sci @SChavezAbiega HA! Just today I finished reading the bioRxiv version

[Babraham Institute @BabrahamInst]

Academia or industry? A choice many researchers have to make during their career

In this post, our Acting Director Dr Simon Cook shares his experience about this decision: https://t.co/bCzwrn2K4Y
#FromTheArchives #NationalCareersWeek

[Erik A. Rodriguez @erin_rod_phd]

How to Maintain an RNase-free Lab
"Human skin and body fluids such as saliva, tears and mucus, can contain RNases (so don't cry over your samples)."
Sound advice!