Dr. Zomboss

UNSW｜Bioinformatics
实验室轮转中（2/3）
保持饥饿，保持谦逊。

[Dr. Zomboss @ERCC111164]

不，如果我只是为了成为我，那我将向风暴的中心走去！稳坐高台？不，我不需要！

社会定义的优秀体面、每次都飞蛾扑火般的扑向“正确答案”？不，我不需要！

大声喊出，即为钻石——我将回归最原始的疯狂和热忱，走向风暴的中心去！

[Dr. Zomboss @ERCC111164]

车马未到，其声先闻。我知道，是时候了。

[Dr. Zomboss @ERCC111164]

对你而言，谁都是血包，是吗？

[Dr. Zomboss @ERCC111164]

不想活了，这都什么糟心事

[Dr. Zomboss @ERCC111164]

返校焦虑中

[Chifa King @ChifaKing]

@studentyang 中文写的

[Avi Roy @agingroy]

Some people are born with a faulty gene that protects them from disease. Drug companies find those people, figure out what the broken gene does, and build a drug that copies it. It is the most reliable way to invent a medicine, because the experiment already ran in humans for a lifetime.

1. PCSK9. In 2006, researchers found that people born with this gene disabled had 88% less coronary heart disease. That discovery led to the injectable cholesterol drugs Repatha and Praluent, and three weeks ago, the first PCSK9 pill.

2. ANGPTL3. Families in Italy with this gene broken had very low cholesterol and clean arteries. The copy is Evkeeza, approved in 2021 for severe inherited high cholesterol.

3. APOC3. Broken copies mean very low triglycerides and less heart disease. The copy, Tryngolza, was approved in December 2024.

4. CCR5. About 1% of Europeans carry two broken copies and are essentially resistant to HIV, because the virus uses that protein as its door into cells. The copy is the drug maraviroc, and the only people ever cured of HIV got transplants from those donors.

5. Lp(a). People born with low levels of this particle get less heart disease. Five drugs copying that state are in late trials; the first big readout is due any week now.

6. FNIP1. Found on Tuesday, in a million genomes. One broken copy, 60% lower odds of heart disease, diabetes, and fatty liver. The hunt for the copy has just started, with a catch: the pathway it works through, when fully broken, causes a kidney cancer.

One gene taught us to lower cholesterol. Another taught us to block HIV. The next lesson was published this week.

[Dr. Zomboss @ERCC111164]

上班☕️

[縱橫日本 @zonghengjp]

熊本地震發生時，八代市綜合醫院手術室內的監視器，記錄下了地震發生瞬間的畫面。
當醫療器材因劇烈搖晃失控時，主刀醫師以自己的身體護住麻醉中、正在接受手術的患者……

[Dr. Zomboss @ERCC111164]

呵呵，今天练臀腿给我练晕倒了。。往地上一躺差点就不省人事了。。。对自己好点吧孩子。

[Semiconductor Bull @WaferBull]

@luo_yuehan Hmm… so we get angry when people want to come and stay legally, and get offended and surprised if someone wants to come legally and leave.. 🤔

[Dr. Zomboss @ERCC111164]

吃饭吃到一半开始哭、一直哭。

[Dr. Zomboss @ERCC111164]

技术上看不懂就算了啊，我都用大白话讲了把我思路用文档发出来了，不会查吗？能不能给点尊重！沟通有问题做事也有问题，你妈的真是完蛋了

[Dr. Zomboss @ERCC111164]

妈逼的真不想干了，说了大半天需要协作协作，我他妈我做出来了你们临床给不到结论这成果能要吗，操你妈，还让我先做。
操你妈我都说了讨论了，讨论呢？操你妈，你他妈的没给我一个合理的方案还敢叫我做，我他妈凭什么做。我真的无语了，有病吧，医学生的质量真是参差不齐

[Dr. Zomboss @ERCC111164]

你他妈但凡用任何一个ai查一下都不该继续用这个结果，吗的真无语，对着答案出题目，666

[Dr. Zomboss @ERCC111164]

操你妈，还怎么办，不要了呗怎么办。烂成一坨屎的数据还要来干什么，操你妈到底怎么毕业的。你的科研思路呢？你的科研精神呢？？

[Dr. Zomboss @ERCC111164]

你好大的官威啊，你们一个压一个的结局就是谁都做不出来成果。我会说这是活该。

[Dr. Zomboss @ERCC111164]

好toxic，提出一个新的猜想和实验思路课题组里的所有人全都不看直接让我开始做。真的有病，你凭什么跟我拿共一，从头到尾都是我在忙。上一个结果不支持这个猜想后又没有人出来说应该怎么调整方向，合着是要无中生有吗？

现在我又重新跑了两轮思考过后得到启发觉得可以把问题拆解，并且愿意继续投入时间和精力去重做。结果居然有人只关心之前的临床结果怎么办？那我请问，临床统计出来结果了吗？？？样本量足够了吗？这是个具有统计效力的结果吗？能在科学叙事上进行解释吗？？？

怎么了，是害怕重新收集数据费时费力吗？是觉得我之前决策错误了吗？是觉得因为我所以导致现在出不来成果吗？那我问你，是谁开的这个题，那我问你，谁跟你说做科研是一做就做成功的。数据不支持就是不支持啊，什么意思。不就是做过一轮了知道这个方向走不通所以才能够去调整下一个方向吗？什么意思，好toxic。你要有先见之明就该说啊，一早就说啊，又不讨论又不指导，在叫什么？

一直在说好好好，先做先做，合着觉得我做干实验的天天wfh很easy很舒服呗？？思路上0指导、每周的logs也不cross-check然后一起讨论过。就知道压力我，跟我说收集数据很累，就知道压力我，跟我说之前的临床结果怎么办。wtf？我把新的思路提出来不就是让你们参与讨论吗？你哪怕看不懂扔给gpt自己理解思考一下呢？看都不看就在那叫，危害到谁的利益了？做不出来大家都没好果子吃。到底什么意思，你妈的真给我压榨完了

[Dr. Zomboss @ERCC111164]

狂得很，在咨询哈佛博士申请😄

[Dr. Zomboss @ERCC111164]

😩😩😩😩😩

[Dr. Zomboss @ERCC111164]

ig就是用来装逼的地方啊……bitch。被贱人的大头照跳脸嚇死了。真该删掉一些人了