elevyLab

We are explorers and architects of cell's proteome.

[elevyLab @ElevyLab]

Our latest work on #phaseseparation! We know changing environments can alter protein phase separation in cells, but can genetic changes do so as well? We addressed this by analyzing the phase-separation of a synthetic system in the yeast KO library 👇 https://t.co/bUnSoMTRhP

[elevyLab @ElevyLab]

Congrats Yifat!

[Igor Ulitsky @IgorUlitsky]

Huge kudos to @WeizmannScience's @Sys_Immunology Yifat Merbl, included in @Nature's 10.
This scientist found a new trick of the immune system by digging through cellular rubbish https://t.co/yEfSQc3XfB

[Rachel Kolodny @rachelkolodny]

Our new AI model CLSS that can co-embed protein sequences and structures is out at https://t.co/b03jvIrQOl.
We use a CLIP-like lean contrastive model (~35M million trained parameters!) and have super-exciting results.
With Guy Yanai, Gaby Axel, @LiamLongo, and Nir Ben-Tal.

[Andreas Boland @BolandLab_GE]

If you are looking for a PhD position in a world class institution in one of the most beautiful places in the world - come to beautiful Geneva! 🗻⛵️☀️

[elevyLab @ElevyLab]

And cool to see our work featured in the journal! https://t.co/5tMxfquoCk Thanks Rui Sun and Yu Liu ☺️

[elevyLab @ElevyLab]

Today is exactly a year after the first tweet. Thrilled to see our work is now online @MolSystBiol ! https://t.co/jn4qEGgesG

[elevyLab @ElevyLab]

Years ago, we discovered that missense mutations in homomeric proteins can induce their supramolecular assembly, as in the 📽️👇 - Question: how are such aberrant assemblies of *folded* proteins handled in a eukaryotic cell? The answer here: https://t.co/WyLwfeDPLQ + 🧵 below

[Biologie - UNIGE @Biologie_UNIGE]

🚨 Job opening in the @MoCel_Geneva Department for an Assistant (tenure-track) or Associate Professor position @unige_en

[Andreas Boland @BolandLab_GE]

We want you! Join the Department of Molecular and Cellular Biology @MoCel_Geneva at the University of Geneva @unige_en @UNIGEnews @sciences_UNIGE
and become our new colleague!
Assistant (tenure-track) Professor or Associate Professor! Please RT - thanks
https://t.co/mQzmG00cxA

[Martin Pacesa @MartinPacesa]

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, @csche11h, @sokrypton, @befcorreia and many other amazing lab members and collaborators.

https://t.co/PTMoqQqwcU

[proteinsociety @ProteinSociety]

March 19 deadline - don't forget to submit your abstract for $500/$1000 Travel Awards and Open Talks for our 39th Annual Symposium in San Francisco. Abstract submission fee is $15 for student members and $30 for all other students. The Protein Society is committed to awarding 100 travel awards to support students world-wide.

[elevyLab @ElevyLab]

If you were looking for a tool to run massive protein complex structure alignments, here’s Foldseek Multimer, based on the already classic Foldseek👇

[Nature Methods @naturemethods]

Foldseek-Multimer is a strategy for complex-to-complex protein structure alignment to quickly perform large-scale structural comparisons between complexes. @thesteinegger @ElevyLab

https://t.co/WqKhvWpdKQ

[Biologie - UNIGE @Biologie_UNIGE]

📻Interview de Prof. Levy @ElevyLab pour l'émission #CQFD de la #RTS : Du nouveau sur la formation des protéines https://t.co/Zpoe48ZjZ1 @MoCel_Geneva @sciences_UNIGE @UNIGEnews

[UNIGE_en @unige_en]

A study by UNIGE and the Weizmann Institute reveals how certain proteins assemble as soon as they are synthesized, ensuring their stability and efficiency. @WeizmannScience @sciences_UNIGE
#UNIGE #biology #research
https://t.co/sCtzjuFLsN

[Biologie - UNIGE @Biologie_UNIGE]

Congratulations @ElevyLab for your latest publication in @CellCellPress : Structural determinants of co-translational protein complex assembly @MoCel_Geneva @sciences_UNIGE
👉Full text: https://t.co/SxfOein6C6

[elevyLab @ElevyLab]

I am thrilled to say that our work is now online @CellCellPress ! I've analysed protein structures for quite some time, but @Robb_Mallik, who co-led this work, took these analyses to yet another level - 🧵👇

https://t.co/BaNJYKow4I

[elevyLab @ElevyLab]

🔥Cell biology meets structuromics🔥 1000s of proteins assemble co-translationally but we don't know why🤷‍♂️ @Robb_Mallik found it’s all about protein 🧩structure🧩, with implications for #gene_expression, #proteostasis, #evolution & #mRNAlocalization 🧵👇
https://t.co/I1novampB6

[elevyLab @ElevyLab]

Super cool simulations from the HarmonLab model a synthetic system from our lab that exhibits phase-boundaries measurable in cells. The simulations relate PS behavior to protein shape/conformation. Now I want to design conformation-regulated PS! https://t.co/A0XoP1CpPm

[CellWalk @CellWalkApp]

CellWalk is now available on the @AppStore for iPhone and iPad! The future of biology education is interactive and immersive.

https://t.co/zlNDOva27A

[Kyle Tretina, Ph.D. @AllThingsApx]

Accelerated computing is revolutionizing protein structure prediction, starting with lightning-fast multiple sequence alignments.

Read more about #AlphaFold and #MMseqs2GPU:
https://t.co/Jv45k1PEmO

[elevyLab @ElevyLab]

Let the fun resume! I wonder how many AAs it will fold with 24 and 48GB cards https://t.co/YllPL7F9y5

[Weizmann Institute @WeizmannScience]

Apply Now for the Max Planck-Weizmann Joint Postdoctoral Program in the fields of:
• Life Sciences
• Chemistry
• Physics
• Earth Science
• Math
• Computer science

Includes a fully funded four-year position, split equally between the two institutions >>

[elevyLab @ElevyLab]

This was led by fantastic Meta @metaheidenreich and an awesome collaboration with @LiamHoltLab with support 🙏 from @HFSP , @ERC_Research , and #ISF

[elevyLab @ElevyLab]

Our latest work on #phaseseparation! We know changing environments can alter protein phase separation in cells, but can genetic changes do so as well? We addressed this by analyzing the phase-separation of a synthetic system in the yeast KO library 👇 https://t.co/bUnSoMTRhP

[elevyLab @ElevyLab]

Anecdotally, we identified an ORF of unknown function (YLR402W) as an influencer of phase separation and cell size - it could be called AIS1 for "Altered Intracellular phase Separation 1"