Eligo Bioscience

Developing new precision medicines to treat the microbiome | WEF Technology Pioneer | #SyntheticBiology #CRISPR #Phages #GeneTherapy #Microbiome

[David Bikard @dbikard]

Eligo Bioscience is hiring for the following roles:
Senior Biochemist Scientist
Microbial Synthetic Biologist
Bioinformatics Scientist
Regulatory & Quality Manager

Join us in shaping the future of precision microbiome medicines!!!! Apply here: https://t.co/CtBTouTkL1 @EligoBio

[Eric Topol @EricTopol]

The ability to manipulate the gut microbiome was restricted to pre- and probiotics,FMT. Now there's successful #CRISPR base editing
https://t.co/0ayLR3YWQq
@justsaysinmice
@Nature @EligoBio @dbikard @duportet

[Genetic Engineering & Biotechnology News @GENbio]

Researchers at Paris-based @EligoBio have engineered a phage-derived vector to deliver a base editor and modify E. coli while they are colonizing the mouse gut. Learn more: https://t.co/0nFRWPqzwA

[David Bikard @dbikard]

1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology https://t.co/efTztuluN9

[Alexander A. Morgan, MD PhD @genomicsdoc]

Cool new work from @EligoBio.

[Eligo Bioscience @EligoBio]

Thank you @CrisprMedicine for the article!

[CRISPR Medicine @CrisprMedicine]

𝐁𝐫𝐞𝐚𝐤𝐢𝐧𝐠: 𝐄𝐥𝐢𝐠𝐨 𝐁𝐢𝐨𝐬𝐜𝐢𝐞𝐧𝐜𝐞 𝐑𝐞𝐩𝐨𝐫𝐭𝐬 𝐅𝐢𝐫𝐬𝐭-𝐄𝐯𝐞𝐫 𝐢𝐧 𝐕𝐢𝐯𝐨 𝐌𝐢𝐜𝐫𝐨𝐛𝐢𝐨𝐦𝐞 𝐁𝐚𝐬𝐞 𝐄𝐝𝐢𝐭𝐢𝐧𝐠

In an article published moments ago in Nature, the company demonstrates for the first time ever that it is possible to target a bacterial genome with extreme precision and efficiency in the gut of a living mouse.

Speaking with CRISPR Medicine News, Eligo Bioscience' CEO Xavier Duportet said:

»It's really the first time we can envision creating therapies that can precisely inactivate the bacterial gene(s) driving disease while having close to no impact on microbiome composition and function. This could be a paradigm shift, switching from microbiome therapies to gene-editing therapies targeting bacterial genes - this strategy broadens the landscape of addressable therapeutic targets in the gene-editing field«.

Read more 👇🏻

https://t.co/6OdEmG8HU0

Photo L-R: Jesus Fernandez-Rodriguez, PhD (VP of Technology, Eligo Bioscience), Xavier Duportet (Co-founder and CEO, Eligo Bioscience), David Bikard (Co-founder, Eligo Bioscience and Professor in Synthetic Biology at Institut Pasteur, France).

#crisprmedicinenews #crisprmedicine #crispr #baseediting #microbiome #breakingnews #researchbreakthrough

[Eligo Bioscience @EligoBio]

With this work we show that the targeted mutagenesis of gut bacteria in situ - something that was inconceivable before - can actually be done!

There is now an exciting road ahead for @EligoBio to develop first in class drugs based on this strategy. #ImmunoInflammation #Oncology

[Eligo Bioscience @EligoBio]

🚀 Very excited to share this work from our amazing scientists at @EligoBio.
🧬 We show that targeted mutations can be introduced with high efficiency directly in the gut microbiome - even without the need for selection!
Thread below... https://t.co/ynQoAsNJFC

[Eligo Bioscience @EligoBio]

💯 Experiments in a mouse model of E.coli gut colonization showed indeed that up to 99.7% of target bacteria can be edited, without selection and without maintenance of a transgene.
⌛️Edits remain stable for at least 42 days!!!! (more data to come…)

[Eligo Bioscience @EligoBio]

Exciting times for Eligo with favorable and decisive ruling from the USPTO in interference case on CRISPR-Cas antimicrobials.
https://t.co/BS4FTxkYMz

[Eligo Bioscience @EligoBio]

Hello microbiology and molecular biology students in the EU! Are you looking for an internship to improve your lab skills while making meaningful contributions to exciting new drug projects? Eligo wants to hear from you, we are recruiting! https://t.co/dB7Pk0XQzy #microbiome

[Eligo Bioscience @EligoBio]

It's an exciting day at Eligo! We have presented data demonstrating that our lead drug candidate, EB003, could alleviate symptoms in 100% of treated animals in a disease-relevant model.

https://t.co/OWfsvqRaIi

[Eligo Bioscience @EligoBio]

Welcome to the team @HesselEdith
#InternationalWomensDay #GoGoEligo!
https://t.co/V6FaSkf5xz

[GSK @GSK]

We are delighted to join forces with @EligoBio, a biotech company that is pioneering #microbiome engineering. With this partnership, Eligo’s #CRISPR technology will be accelerated thanks to our scientific excellence and capabilities 👇