Enable Biosciences

South San Francisco-based biotech company specializing in antibody detection.

[Enable Biosciences @EnableBio]

We will be attending the American Diabetes Association's 83rd Scientific Sessions this weekend in San Diego! Come visit our team at Booth #1815.

#ADA2023
#type1diabetes

[Enable Biosciences @EnableBio]

Congratulations to Enable cofounder @CarolynBertozzi for winning the Priestley Medal, the highest award offered by the American Chemical Society!

[Krzysztof Potempa @BRAINCURES]

After launching 7 companies (Thios, Redwood, @EnableBio @Palleon_Pharma @vennbio @gracescience @OliluxB @LyciaTx) in 12 years, @CarolynBertozzi the prolific biotech business founder says she’s always on the lookout for problem-solving opportunities @cenmag
https://t.co/Qr9WCSpKhE

[EASD @EASDnews]

It's our honour to announce that Professor Åke Lernmark is the recipient of the EASD Claude Bernard Prize 2023, recognising his innovative leadership and lifetime achievements in #diabetes #research.
Congratulations @AkeLernmark👏, we look forward welcoming you at #EASD2023

[Enable Biosciences @EnableBio]

Pere Santamaria of Parvus Therapeutics describes tolerogenic peptide-mhc coated nanoparticles ("navacims").

Promote differentiation of antigen-specific autoreactive t cells into treg-like cells.

1/x

#ids2023

[Enable Biosciences @EnableBio]

Anti inflammatory signatures observed w varapamil treatment, as well as downregulation of various HLAs.

Screened for novel TXNIP inhibitors, oral treatment w candidate TIX100 rescues mice from obesity- and STZ- induced diabetes.

2/x

#ids2023

[Enable Biosciences @EnableBio]

Professor Anath Shalev from @UofAlabama describes repurposing of TXNIP inhibitor verapamil for beta cell protection.

Mechanism unclear, but verapamil treatment in new onset T1D causes downregulation of autoantigen chromogranin a.

1/x

#ids2023

[Enable Biosciences @EnableBio]

Annette Ziegler describes a subset of stage 1 diabetes with >50% chance of progressing to stage 3 type 1 diabetes in the next two years.

This higher-risk stage 1b cohort might be viewed similarly to stage 2 individuals.

3/x

#ids2023

[Enable Biosciences @EnableBio]

Ezio Bonifacio opens autoantibody screening strategy session.

99% specificity may sound good, w low prevalence diseases there will still be a surplus of false positives.

Need to follow up w more specific assays, while taking into account assay-specific behavior.

1/x

#IDS2023

[Enable Biosciences @EnableBio]

Screening assays should emphasize sensitivity over specificity to pick up all true positives.

Validation assays should emphasize specificity over sensitivity to ensure low false positive rates.

Both assays shld use small volume samples for ease of collection and analysis.

2/x

[Enable Biosciences @EnableBio]

Anti-cytokine therapies show success, but require continuous infusion to maintain efficacy.

Suggests a 3-prong combination therapy approach to T1D prevention/delay by modulating the immune system while promoting beta cell health.

2/x

#ids2023

[Enable Biosciences @EnableBio]

@umiamimedicine Professor Jay Skyler gives an overview of the past, present, and future of prevention/delay studies for type 1 diabetes.

T-cell inhibition therapies show success, but it's hard to identify Stage 2 patients for trials and clinical care.

1/x

#ids2023

[Enable Biosciences @EnableBio]

We are a Silver Sponsor at #ids2023 in Paris!

Come by and:

1. Visit our booth to learn about ADAP T1D Autoantibody Assays and more.

2. Visit us at Poster #38 on Friday.

Hope to see you in Paris!

#T1D
#Paris
#immunology

[Dr. Jessica Dunne @jessdunnephd]

Are you going to #IDSParis2023 this week? If so, join ⁦@WIELDvoice⁩ on Thursday before the gala for an informal gathering & to learn more about who we are & what we do.

[Enable Biosciences @EnableBio]

Read why Rosie T got tested for type 1 diabetes!

[Beyond Type 1 @BeyondType1]

If you are diagnosed with type 1 diabetes, your risk of getting celiac disease increases tenfold.

Here's more about the symptoms.
https://t.co/2ZX5o6QZYW

[Enable Biosciences @EnableBio]

Did you know?

Enable Biosciences' T1Define Type 1 Diabetes test has been validated with thousands of samples with over 8 peer-reviewed publications.

#t1dlookslikeme
#t1d
#type1diabetes

[Beyond Type 1 @BeyondType1]

Screening for type 1 with @JDRF's T1Detect prevents life-threatening DKA at diagnosis.

It lets you catch T1D early so you can enroll in trials that delay diabetes onset.

It's one more thing @GingerVieira can do for her kids. #SeeTheSigns https://t.co/SzLtt22Mpu

[Beyond Type 1 @BeyondType1]

Why are we so passionate about helping people #SeeTheSigns? Because DKA is life-threatening, and getting a correct diagnosis shouldn't come down to luck. https://t.co/XSoynTqslR

[Enable Biosciences @EnableBio]

“To get an early diagnosis is so critical. If you can catch type 1 before DKA, you’ve saved yourself the possibility of brain damage... And so that early recognition is so vital, not just because of the scariness of DKA, but because of the unknown that comes with it.”

[Beyond Type 1 @BeyondType1]

Kycie Terry passed away at age 5 from complications caused by a missed type 1 diabetes diagnosis.

Her death was preventable.

Her story has saved lives. #SeeTheSigns https://t.co/Ytec3R7KpQ