Engle Lab

catalysis, reaction discovery, and samoyed sled racing @scrippsresearch. views our own.

[Engle Lab @EngleLab]

🎥 My graduate-level #Organometallics course is now live on @YouTube! #chemtwitter

Designed for PhD chemists, this series covers history, mechanisms, catalysis, ligand design & more. Offered once every 2 years—check it out anytime!

📺 https://t.co/tu6Yphmugu

[Engle Lab @EngleLab]

Bench-stable Ni(II) precats w/ superb solubility that activate cleanly & work ↔️ Suzuki–Miyaura, Buchwald–Hartwig, Miyaura borylation, and olefin difunctionalization. The final version of Nana & Aimee's Ni(C6F5)2 paper is out @Orgmet_ACS #BMSChemistry https://t.co/eUyoYnWL7B

[Engle Lab @EngleLab]

We found an unexpected byproduct in our cyclopropanation work. X-ray structure ➡️ isoxazoline N-oxide. We optimized for this [3+2] product, figured out the scope, and now share the final story in @JOC_OL 🔗 https://t.co/4vTlvlTlu8

[Engle Lab @EngleLab]

Bidentate DGs are a powerful tool for controlling reactivity and selectivity in π-bond functionalization—and for mechanistic elucidation!
Great seeing growing adoption and pleased to team up w/ @TaehoKang6's lab to review the state of play! @angew_chem https://t.co/IYNEQdtTOm

[Engle Lab @EngleLab]

Together w/ @pengliu_group & #BMSChemistry we inverted the classical selectivity paradigm of organometallic additions to Michael acceptors, achieving enantioselective anti-Michael addition of (hetero)aryl groups under Pd/PhTRAP catalysis. https://t.co/G5FKNRHT04

[Engle Lab @EngleLab]

5+ years developing stable Ni catalysts—and always battling poor solubility!

Inspired by the inorg chem literature, our lab w/ a team from @UCSDChemBiochem & #BMSChemistry now report [Ni(C6F5)2] precats w/ superb solubility, stability & convenience.

https://t.co/6Lv6RyP7QO

[Engle Lab @EngleLab]

The final peer-reviewed version of this collaborative study w/ #BMSChemistry, @pengliu_group, and @GuteGroup is online @ACSCentSci.

Alkyl-9-BBN reagents have quickly proven simple and surprisingly effective in numerous 3-component couplings in the lab!

https://t.co/FuurQCkSfC

[Engle Lab @EngleLab]

C(sp3)-C(sp3) couplings w/o radicals? 🧐

We introduce alkyl-9-BBN reagents to the 3-component coupling party 🎉, enabling access to new encoded cyclooctene monomers for ROMP 🧵

w/ @pengliu_group @GuteGroup

@ChemRxiv: https://t.co/kXrINZmAcS

🧪 #TeamNickel #PolymerChem

[Engle Lab @EngleLab]

The final peer-reviewed version of our collaborative study w/ #BMSChemistry, @EnamineLtd, @pengliu_group, & the Blackmond lab developing a flexible directing group for expanded scope in olefin hydroamination is online @J_A_C_S. Bravo @avrlisboa and team!
https://t.co/OLGyJYZHxN

[Engle Lab @EngleLab]

🔧 In a mechanism🔁method tour de force, @avrlisboa & team show that a flexible directing group dramatically improves Pd-catalyzed functionalization of hindered olefins, leading to >115× rate boost and expanded scope. @ChemRxiv https://t.co/BaHBAFxvjV

@pengliu_group @EnamineLtd

[Engle Lab @EngleLab]

Honored to play a small part in this seminal study—putting Pd(COD)(DQ) to use in a tricky C–N coupling, setting the stage for high-throughput SuFEx. Great to collaborate with molecular glue discovery masters upstairs!

[Michael Erb @Michael_A_Erb]

What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery.

More thoughts and details here: https://t.co/k1Ylnzd3Cj

Paper here: https://t.co/XtTiavWZcr

[Engle Lab @EngleLab]

The final peer-reviewed version of our Ni(DQ)2 study hit the presses @Orgmet_ACS earlier this month.

Update regarding commercial availability coming soon!

https://t.co/2kMPv3HimN

[Engle Lab @EngleLab]

The newest chapter in air-stable Ni(0):

Ni(DQ)2

@ChemRxiv pre-print: https://t.co/ZgzW2vbqqf

@HarryHe88239850 @SongLinLab #BMSChemistry

[Tamara E @chemistte]

Hey @Support @Safety @X,
Our lab account @BaranLabReads was suddenly suspended, but we have exciting science to share! Appeal was submitted can you please help?

Calling on our science collaborators & friends to please RT for visibility. @ScrippsResearch

[Nature Synthesis @NatureSynthesis]

Now online and open access:

Article by @MykhailiukChem @pengliu_group K. Barry Sharpless, @englelab & co-workers

Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes

https://t.co/LZ8PG5xdlz

[Engle Lab @EngleLab]

The final version of @YilinCao_chem's study, reporting a unique approach to olefin cyclopropanation w/ Alkyl-SO2F compounds is now online in @NatureSynthesis!

https://t.co/do1IFYPSaX

[Engle Lab @EngleLab]

The rise of SuFEx has focused a bright spotlight 🔦 on synthesis of RSO2F compounds.

What reactivity beyond SuFEx do these compounds possess and how can we unlock it? 🔐

@YilinCao_chem and team have the answer.🔎

https://t.co/UJlMezNToe

[Engle Lab @EngleLab]

🔧 In a mechanism🔁method tour de force, @avrlisboa & team show that a flexible directing group dramatically improves Pd-catalyzed functionalization of hindered olefins, leading to >115× rate boost and expanded scope. @ChemRxiv https://t.co/BaHBAFxvjV

@pengliu_group @EnamineLtd

[Scripps Research @scrippsresearch]

When you make a gift, you provide Scripps Researchers the time, resources and freedom to investigate problems without easy answers, like why cancer becomes resistant to treatment or how to stop neurodegeneration before it starts. This #GivingTuesday, help us shape the future of human health: https://t.co/hpWKH5iRrb

[Scripps Research @scrippsresearch]

From writing messages with invisible ink to making liquid nitrogen ice cream and exploring viruses through virtual reality goggles, these were just a few of the interactive experiences featured at Discovery Day at @fleetscience. Watch the full event recap: https://t.co/Nj1qAZWLFH

[Engle Lab @EngleLab]

@HumApplby @ChemRxiv @HarryHe88239850 @SongLinLab Great idea, please check out this paper from the Mori lab: https://t.co/6omsj6adWz

[Engle Lab @EngleLab]

The newest chapter in air-stable Ni(0):

Ni(DQ)2

@ChemRxiv pre-print: https://t.co/ZgzW2vbqqf

@HarryHe88239850 @SongLinLab #BMSChemistry

[Scripps Research @scrippsresearch]

Modeyso™, the new FDA-approved treatment for a rare and aggressive pediatric brain cancer known as diffuse midline glioma, marks the 18th therapy that Scripps Research scientists have helped advance, thanks in part to two former members of the Janda lab. https://t.co/s6f6aH00U0

[Engle Lab @EngleLab]

We’ve loved promoting @fleetscience Discovery Day all week, and it starts TODAY at 10 AM! Stop by to meet @scrippsresearch students & postdocs and explore hands-on science fun. 🔬🌟 #CommunityScience #STEMEducation

[Scripps Research @scrippsresearch]

Lights, camera, science! 🎬🔬🌟 Scripps Research Dean of Graduate and Postdoctoral Studies Keary Engle, PhD (@EngleLab), and postgraduate students Jia Meng Pang (@JiaMeng_Pang) and Paige Bensing joined @KUSINews to share a sneak peek of Discovery Day at @fleetscience!

[J. Am. Chem. Soc. @J_A_C_S]

Equivalent Atrop- and Positional Isomerism in Styrene Derivatives Prepared by Enantioselective 1,3-Diarylation | Journal of the American Chemical Society @EngleLab @scrippsresearch https://t.co/rrnGLDYzoO