Mark Rice

Interested in biotech. Try to learn something new each day

[Mark Rice @Envirominer3]

@MikeSheikh2 @ButlerNash81070 The oncologist at Dana Farber said Galectin-3 staining is an outdated technique, she is a 30 year oncologist AND current professor at Mass General even when presented with a preprint article in Nov-Dec 2025! They are very out of touch W/advances in Gal-3 and CCR5! Discouraging

[Mark Rice @Envirominer3]

@MikeSheikh2 @ButlerNash81070 Getting oncologists to stain for Gal-3 even at sites such as Dana Farber and their affiliate sites is a real challenge! It took numerous verbal requests, (6) PubMed articles and then a written request before biopsied tissue could be stained.

[Dan Komaromi @DanKomaromi]

Galectin-3 inhibition as a potential therapeutic target in non-alcoholic steatohepatitis liver fibrosis

#liver #hepatology #NASH #fibrosis #cirrhosis #liverdisease #livertwitter

https://t.co/BCD7VEEL5y

[Mark Rice @Envirominer3]

@agnesperezmi @sanchezvaller @Antbozser84 @BorregoSergi @idibaps @hospitalclinic Nice work @agnesperezmi ! What is your opinion on down-regulation of Gal-3 with a Galectin 3 inhibitor like belapectin (GR-MD-02) ? It seems as if this would be a great study to help those suffering with AD

[Dan Komaromi @DanKomaromi]

Galectin-3 in biliary atresia and other pediatric cholestatic liver diseases

“Galectin-3 targeted therapy may be beneficial in slowing disease progression to cirrhosis in children with BA.”

https://t.co/4DG1b31lja

[Dan Komaromi @DanKomaromi]

“Galectin-3 oligomers are thereby identified as decoders of defined spatial patterns of N-glycans and as functional extracellular interactors of specifically the bent-closed conformational state of α5β1 integrin and possibly other family members.” https://t.co/63zfY1idAL

[Greg Hudalla @GregHudalla]

Very nice to see this News & Views from @gabyrabi and colleagues on our recent @natBME paper describing Galectin-3 anchored IDO as an anti-inflammatory!

@keselowsky @OrthoBME @Duvall_Lab_VU @UFBME @UFWertheim

https://t.co/xxYIDlQuok

[Dan Komaromi @DanKomaromi]

Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH Oxidase 1

https://t.co/C2U0LTUsRD

[Dan Komaromi @DanKomaromi]

New from Germany —
Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19

https://t.co/jsKRQuD7S6

[Mark Rice @Envirominer3]

@EnemyInAState Here is 2018 article that may give you more insight into the potential of Galectin-3 inhibitors. Galectin Therapeutics, a Georgia based company, has been at the forefront with belapectin (GR-MD-02) for years!

https://t.co/3rCEdf3NVi

[Mark Rice @Envirominer3]

Very insightful article/review, author covers in detail the role Gal-3 plays in #NASH & liver fibrosis & the potential Galectin-3 inhibitors belapectin & GB1107 could contribute towards the NASH epidemic
@AASLDtweets @NASH_AWARE @liverUSA @LiverForum

https://t.co/C2r1ssVCDp

[Mark Rice @Envirominer3]

@jaimy_lee How does the FDA square approving ICPTs obeticholic acid if in addition to intense itching there are concerns w/aggravating liver injury and CONTRIBUTING TO FIBROSIS (NASH)? Also your article failed to mention Galectin therapeutics “belapectin” currently in phase 2b/3 trials

[Dan Komaromi @DanKomaromi]

Unraveling the pathophysiologic role of galectin-3 in chronically injured liver

#NASH #cirrhosis #NAFLD #HCC #liver #cancer #hepatocellular #carcinoma #hepatitis #liverdisease

https://t.co/q8FqhNAXr8

[Marcin Czerwinski @CzerwinsMarcin]

Galectin-3 interacts with PD-1 and counteracts the PD-1 pathway-driven regulation of T cell and osteoclast activity in Rheumatoid Arthritis https://t.co/qmA39cSBKJ

#glycotime

[Marcin Czerwinski @CzerwinsMarcin]

Chimeric galectin-3 and collagens: biomarkers and potential therapeutic targets in fibroproliferative diseases @jbiolchem https://t.co/XpyysPzA6c

#glycotime

[Xiaowu Gu @XiaowuGu]

Here comes an exciting piece from
@ButovskyLab and colleagues! Congrats!

It elegantly lays out how ApoE4 is actually protective in glaucoma as opposed to its detrimental role in the AD, and puts Galectin-3 under spotlight as a promising target.

https://t.co/7rRqrRZHLl

[Dimitroff Lab @DimitroffLab]

Would you like to know the most recent data and hypotheses about the role of Galectin-3 in melanoma growth and metastasis?
Check out our new review article!
https://t.co/mnNcK55pqz
Extremely proud of our work and collaboration on this one!!

[Lluís Camprubí Ferrer @lluis_camprubi]

I'm enormously glad to share with everyone that our paper is OUT in Acta Neuropathologica!
We show the role of Galectin-3 as a key pathological marker for #Alzheimers, and its close relationship with microglia. We analyzed human brain tissue and CSF:

https://t.co/1b1mJwlNB2

[Nat Rev Neurology @NatRevNeurol]

Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer’s disease https://t.co/JBunXJuphp

[Centre de Neurologie Cognitive @CNC_Alzheimer]

Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer’s disease. https://t.co/Ffn5zx1pwD