Slava Epelman

Cardio-Immunologist, Macrophages. Associate Prof, Univ of Toronto. UHN. Research Director Peter Munk Cardiac Center. Loretta Rogers Chair

[Slava Epelman @EpelmanLab]

Our latest study, led by @Homaira_H. Hard to study #macrophages (MFs) in early human heart development (no tissue). Homaira integrated human ES-derived-MFs into beating cardiac microtissues & improved🫀function. https://t.co/dZ45GiNEkH. #cardioimmunology #regeneration.

[Miriam Merad, MD, PhD @MiriamMerad]

Congratulations to @jeremiahfaith1, @grinsa01, and @sinaiimmunology on a big milestone in microbiome therapeutics: https://t.co/0tTIbdOidh (1/2)

[ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE @DucheneJohan]

100s labs ordered the wrong "p16" antibody.

They wanted to study p16-INK4a, but bought p16-ARC antibodies.

312 papers got it wrong.

Now the literature is polluted with false mechanistic pathways.

Validate your reagents. But also read the datasheet and use your brain.

[Alex Protonotarios @ProtonotariosA]

Very excited to share our latest paper, published as a Research Letter in Circulation. We show a significant role for adaptive immunity in arrhythmogenic right ventricular cardiomyopathy.
https://t.co/O2BeEsDUgQ

[Luke_Brown_91 @Luke_Brown_91]

Sepsis is a balancing act: too little immunity fails to control infection, too much causes tissue damage. Our @ScienceMagazine paper reveals one mechanism behind this tradeoff.
https://t.co/D0IXKZyjfu

[Eric Topol @EricTopol]

Using smartphone facial video clips with AI to passively and accurately get heart rate, across all skin pigmentation groups @nature
"This is the first demonstration that smartphones
can be used to monitor both HR and daily RHR passively during normal personal phone use in the real world."
https://t.co/cYz94D2ZGU

[Eric Topol @EricTopol]

There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
https://t.co/e04jqJMPw0

[Chris Y @drchrisyu]

1/ Can we predict who will develop #cardiotoxicity from #cancer therapy before starting treatment?
We built a deep learning model that does that, using #CMR images alone. A thread on how 👇
📝link: https://t.co/QHWnjpnyIF
#cardioonc @dineshpmcc1 @CmcintoshAi @ICOSociety

[Marios Georgakis @MariosGeorgakis]

🔗link to the preprint: https://t.co/JrYsdKObeb

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

６週のマウス全身の空間トランスクリプトーム解析結果の論文。CELL誌。
https://t.co/n7b4gyzgYx

[Waggoner Lab @LabWaggoner]

Native long-read RNA sequencing of human monocytes reveals activation-induced alternative splicing toward functional isoforms @NatureComms @UniUtrecht
https://t.co/w32sKsgQQ5

[Waggoner Lab @LabWaggoner]

Review @SciImmunology
The transcriptional and epigenetic regulation of macrophage differentiation, specialization, and activation in health and disease
https://t.co/Woxrw6xR6N

[Aging Science News @AgingBiology]

Transcription-independent induction of rapid-onset senescence is integral to healing
https://t.co/liVCtUmtBJ

[Slava Epelman @EpelmanLab]

@SaligramaLab This might be the most interesting macrophage function I have ever heard of.

[Saligrama lab_WUSTL @SaligramaLab]

This is #wild and #fascinating -"Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions" https://t.co/OksckAbZlA

[Eric Topol @EricTopol]

With aging, cells lose their identity and undergo a mesenchymal drift. Reversing this drift may be a way to mitigate aging and promote healthspan. A new @CellCellPress review
https://t.co/fr4N6b75Im

[Slava Epelman @EpelmanLab]

@bgyipp @sarah_h_ross @aaas @ScienceMagazine @NSERC_CRSNG @CIHR_IRSC @Luke_Brown_91 Super cool sepsis imaging study, congrats Bryan and Luke!

[bryan yipp @bgyipp]

Congrats to Dr. Luke Brown on his PhD discoveries
@sarah_h_ross @aaas @ScienceMagazine @NSERC_CRSNG @CIHR_IRSC @Luke_Brown_91
Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice | Science https://t.co/nCtaNTKUJA

[Eric Topol @EricTopol]

Important #LongCovid finding of auto-antibodies in patients directed to neural tissue, and then, by transferring the antibodies, recapitulated the disease symptoms in mice @CellCellPress @VirusesImmunity @putrinolab
https://t.co/s4bSXjTVe6

[Farooqi Lab @Farooqi_Lab]

In a paper just published in @sciencemagazine, we teamed up with @teichlab to construct the most detailed atlas to date of hormone production and action in humans at cellular resolution. (1/8)

Link: https://t.co/5iPOCq9yfu

[Nature Biomedical Engineering @natBME]

Cell-based cytokine patch for localized immunomodulation and accelerated healing in rodent and porcine wounds https://t.co/DfmgdsY1g1