Slava Epelman

Cardio-Immunologist, Macrophages. Associate Prof, Univ of Toronto. UHN. Research Director Peter Munk Cardiac Center. Loretta Rogers Chair. #Cardioimmunology

[Slava Epelman @EpelmanLab]

Our latest study, led by @Homaira_H. Hard to study #macrophages (MFs) in early human heart development (no tissue). Homaira integrated human ES-derived-MFs into beating cardiac microtissues & improved🫀function. https://t.co/dZ45GiNEkH. #cardioimmunology #regeneration.

[Abe Bayer, PhD @AbeBayer]

New paper alert!! Here we show in patient blood samples and animal models that Doxorubicin directly rewires CD8 T-cells into “matrix remodeling T-cells” or “mx-Tcells”allowing them to stiffen cardiac collagen directly through a Lox dependent mechanism

https://t.co/klkaa02rlQ

[Eric Topol @EricTopol]

Just published @Nature
A 3-agent AI personal health agent exceeded performance of a large language model/chatbot and serves as a foundation to build on for integrating sensor data, medical knowledge and coaching
https://t.co/OX0fGyCrgn

[Madam Mitochondria @Madam_Mito]

In mammals, there is no damage accumulation, there is only impaired regeneration capacity.

One of the most interesting findings was a population of Arg1-positive macrophages.
These macrophages were activated in regenerating #young tissues but their activation was suppressed in #aged regenerating tissues.

[Motoshi Hayano @HayanoMotoshi]

山中因子とは違うRejuvenation因子の単離は色んな企業やアカデミアが実施していて、我々のOne Genomicsもこの論文のChurch博士と進めている

っていうのを色々書こうと思ったんだけど、Nature Agingって、インパクトファクター25もあるのね…。驚愕

最初16とかで、まぁそんなもんか、思ってたけど、これが商業の力か。

https://t.co/slKkE6Kjq8

[Michael Alexanian @m_alexanian]

New preprint from the lab: "A Compact Regulatory Logic Governs Fibroblast Cell State Plasticity in Fibrosis". We integrated mouse and human epigenomic data to identify 280 fibroblast disease-activated enhancers, then perturbed them by CRISPRi CROP-seq. 🧵

https://t.co/hyVhQvSkL1

[dineshpmcc @dineshpmcc1]

An absolute pleasure to be with my better half at #CCC 2026 while she presented her work on heart failure discharge criteria and compliance.

[Eric Topol @EricTopol]

Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions
https://t.co/dmcdQJCrnj @ImmunityCP

[Eric Topol @EricTopol]

Microplastics are chemically active, enable spontaneous •OH generation in water, and "have direct
implications for biomolecular adsorption, protein aggregation, and even cellular damage."
@Nature https://t.co/WfNEXsYHu8

[Eric Topol @EricTopol]

Aging clocks, here with metabolites, are remarkably predictive of future health outcomes (top graph) and are telling about an individual's lifestyle factors (bottom graph)
new @ScienceTM
https://t.co/kAG0ArvYTR

[Dan Bromage @BromageDan]

Our latest study suggests colchicine may improve LV recovery after acute myocarditis. Encouraging to see RCTs underway, including ARGO and CMP-MYTHiC, to establish its role. @Sukruth__K @_antocannata @Kings_BHFCentre #myocarditis ❤️‍🔥

https://t.co/9enkirVjxN

[Eric Topol @EricTopol]

It's late 2026 and we still don't have a way to assess a person's immune system status in the clinic, the underpinning of healthy aging. But soon there may be at least 3 ways!
https://t.co/f4A7LaN4Wf

[Marcus Goncalves @MarcusDGon]

Out now in Nature Medicine: a health-system-scale cachexia atlas (52K patients) that describes and predicts outcomes, with prospective risk models for lung, colorectal, and prostate cancer. Congrats to @EdReznik for a landmark paper for the field. https://t.co/DY6qQNevlh

[biohub @biohub]

🧵 Biohub, @ENERGY, @NIH, and new funding partners today announced a major expansion of an international effort to generate and make accessible the data enabling predictive AI models of biology. Together, the organizations are investing $1.8 billion in funding, data, computation and new measurement technology - largest coordinated commitment to map the biology of the cell to power development of digital models of biology. https://t.co/PaCs7ZV2Fg

[Eric Topol @EricTopol]

A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
https://t.co/aQNQiapfPV

[Rahul Satija @satijalab]

Delighted to share RNA fingerprinting, out today in @CellCellPress! Together with @david_a_knowles , we use Perturb-seq experiments—where the causal perturbation is known—to infer what drives cellular responses in new datasets: https://t.co/GdeInpTpTJ

[Waggoner Lab @LabWaggoner]

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial–immune cell interactions @NatImmunol @hostmicrobe
@PennVet
https://t.co/qVSNin6ghS

[Eric Topol @EricTopol]

Unfortunately, the medical community has a singular view of the basis of coronary artery disease—lipids. But we keep seeing ways that heart attacks can occur independent of any lipid abnormality, like this one
New @CellCellPress
https://t.co/GvzsNoJs6r

[Matthias Nahrendorf @MatthiasNahrend]

In @Nature: @teichlab confirms increased tissue resident macrophage density in the ♥️ conduction system, with focus on developing sinus node: https://t.co/8VJ1F4hkM8

Please see screen shots from @MaartenHulsmans paper: https://t.co/VJZBGOtjWA

But what are these macs doing 🤔

[Anne Carpenter, PhD @DrAnneCarpenter]

We are funded!!! And hiring at Purdue and Broad!

JT Neal received an NIH Director’s Transformative Research Award for Project Encore. We'll test 1.6M+ drug-disease combinations in parallel using imaging, to repurpose drugs for rare genetic conditions
https://t.co/7dciPohwEi

[Eric Topol @EricTopol]

Semaglutide (Ozempic) consistently reduced proteomic organ age 2-4 years for the heart, artery, and kidney clocks across 5 placebo-controlled trials
https://t.co/C4KPhUX8nV