Alex Couce

Watching microbes evolve at @CBGP_Madrid. Teaching computational biology at @La_UPM

[Ignacio J. Melero-Jiménez @Ignamelero]

1/7 Excited to share our new preprint! @JFriedman_micro @EvolSys We explored evolutionary rescue in microbial communities, focusing on how obligate mutualisms respond to environmental changes. #MicrobialEcology #EvolutionaryBiology

[Alex Couce @EvolSys]

@RELenski @benjaminhgood Very interesting discussion! Also, to this point on increased DR and sign epistasis, note that the most beneficial mutations we see on the ancestor show a great tendency to cluster together in operons - so it makes sense that most of them would be redundant if combined (Fig. 3B)

[Alex Couce @EvolSys]

Si quereis conocer más detalles, éste es el hilo en inglés escrito por el propio @RELenski, donde podréis encontrar enlaces a los manuscritos originales: https://t.co/eNoG4R8yB9. Fin del hilo.

[Alex Couce @EvolSys]

Esta semana dos trabajos han ampliado nuestra comprensión de cómo el efecto de las mutaciones varía a lo largo de la evolución. Los estudios han sido posibles gracias un experimento que lleva >30 años evolucionando bacterias en el laboratorio. Un hilo.

[Alex Couce @EvolSys]

A nivel práctico, toda vez que las grandes adaptaciones iniciales son a menudo las que marcan la diferencia entre la supervivencia y la extinción, nuestros resultados suponen una inyección de moral a los esfuerzos para predecir la evolución de patógenos (p. ej, @nextstrain).

[Alex Couce @EvolSys]

@DrMikeWiser @baym @ten_olivier Yeah, I guess @barricklab and @RELenski got it covered...

[Alex Couce @EvolSys]

@baym @ten_olivier In this way the LTEE is like the Hubble Space Telescope, different groups can focus on way different questions, on way different timescales...

[Alex Couce @EvolSys]

@baym @ten_olivier Agree. Also, with such large datasets, you feel the need to kinda touch on everything. Coordinating efforts made both groups to focus and dig deeper into what really motivated each one: fragility and robustness to you, epistasis and predictability to us.

[Alex Couce @EvolSys]

@baym Yep, it was an special and inspiring meeting... Kudos to you for taking the first step!

[Arlin @ArlinStoltzfus]

Recent recorded lecture from Alex Couce @EvolSys "Evolutionary consequences of biased mutation ... https://t.co/IgsGwklZLG