D-lab

Small research group whose main goal is to understand RNA-based regulation of gene expression in Helicobacter pylori including toxin-antitoxin systems @INSERM

[D-lab @FabienDlab]

T1TAdb ! the first database dedicated to type I toxin-antitoxin systems ! it currently contains 2065 TA loci from 671 bacterial strains and 21 TA families ! Please visit it and send us your comments ! https://t.co/s1zkGmxRrt

[Tominaga K. (tomiken) @pacyc1841]

» Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements | Nucleic Acids Research | Oxford Academic https://t.co/P0ECRFb5mM

[Yaser Hashem @Hashemyaser4]

It's a great pleasure to share our latest collaborative work detailing the composition and structure of the highly rRNA-fragmented mitoribosome from Apicomplexa, such as Plasmodium falciparum and Toxoplasma gondii, now out in @NatureComms
https://t.co/Ly7JeipU8W

[Jörg Vogel @JoergLab]

I’m late to the phage tail party, still want to congratulate @Jens_Hoer on a great postdoc in the @SorekLab. Figured out function of an ISG15-like protein in phage defence. https://t.co/TFXjDewuW3
Jens is looking for students/postdocs for his own lab, see https://t.co/aLwVYY8EHl

[D-lab @FabienDlab]

Super cool work! Congrats!

[D-lab @FabienDlab]

@ONeyrolles félicitations ! Coucou Marion 💪

[Olivier Neyrolles @ONeyrolles]

And the national winner is!!!!
Wendy!!!!!
💪💪💪🥳🥳🥳🥳🥳🥳🥳🥳🥳

[Papenfortlab @papenfortlab]

ChimericFragments: computation, analysis and visualization of global RNA networks https://t.co/XKKOpW24bq

[Scott Saunders @s_h_saunders]

The “ORBIT for E. coli” paper is out in Nucleic Acids Research! https://t.co/v4HvqMl3NB

**Perform genetics (e.g. deletions) without any PCR / cloning – just transform an oligo!**

The paper demonstrates benefits over λ Red & shows how oligos scale to high throughput libraries.

[D-lab @FabienDlab]

Nice !

[Nara Figueroa-Bossi @narafiguer_I2BC]

Not an April fool! Our paper is out on Nature Comm. We show that bacterial nucleoid structuring protein H-NS can be dislodged, from a distance, by the twisting in the DNA generated ahead of approaching RNA polymerase.
Thanks to all of you, coworkers!
https://t.co/jPPyRaM5bK

[D-lab @FabienDlab]

@GenevauxPierre @CbiToulouse @FRM_officiel Congrats Pierre and the team! Well desserved!

[Papenfortlab @papenfortlab]

The global RNA–RNA interactome of Klebsiella pneumoniae unveils a small RNA regulator of cell division | PNAS https://t.co/KVyx3FDZTB

[Pilhofer Lab @PilhoferLab]

It's out! It's out! 📢The bacterial Tc Toxins are out😱☠️ (and our paper 📜😉)! But how did these huge complexes get out? Where did they assemble? 🧐 Check out Tc Toxins' great escape from Yersina 🦠 @NatureMicrobiol: https://t.co/JEyCUf29Fz #cryoET #toxins #microbiology 🧵1/4

[D-lab @FabienDlab]

@BIRDlab_ENS @SisslerM @_SFBBM Thank you Alice!

[D-lab @FabienDlab]

A really elegant study on PSK! Congrats

[Didier Mazel @amazeld]

I am particularly proud of this study from our laboratory, which explains how integrons have set up a kind of second-order selection. It reminds me of the time of the papiers on the selection of mutators to resist ABs. @FrancoisTaddei, Miro, Ivan, Jesus... https://t.co/U6IWbHcDKK

[Vasili Hauryliuk @hauryliuk]

phage-encoded RNA-binding protein inhibits the antiviral activity of a toxin–antitoxin system https://t.co/PgzlJfgV6t

[good papers @paperperday]

The ribosome as a small-molecule sensor
https://t.co/vghLocxCls

[Alexander Harms @AHarms485]

Exciting new preprint from the group of Kai Thormann @TheThormannDen about a plasmid that uses a filamentous phage for spreading 👇🏼🧬🚕. So much cool biology remains to be found if we look beyond the comfort zone of standard model bugs!

[Itai Yanai @ItaiYanai]

😯 François Jacob (co-discoverer of gene regulation) asked by Lucy Shapiro (Stanford):
"It's always been hypothesis-driven research [..] but a new way is looking at vast amounts of data and not asking a question, just seeing if it give you a pattern."
Jacob: "It’s very boring.."

[Jörg Vogel @JoergLab]

Proud to report that I’m back at the bench, at least temporarily. Can’t find my favourite pipette, though, happy to borrow if you happen to have a spare one.