Metallobiochemistry lab at UTSA

Dr. Aimin Liu's MetalloBioChemistry Lab at the University of Texas at San Antonio (student run).

[Metallobiochemistry lab at UTSA @FeRadLab]

This work is a call for attention and effort to determine the actual redox state of enzyme-bound cofactor or cosubstrate in redox reactions! https://t.co/biJ3RWGOfC @UTSAChemistry @UTSASciences @jbiolchem

[Metallobiochemistry lab at UTSA @FeRadLab]

Hey y'all! Check out our new paper from Ephrahime and company lending understanding to L-Tyr's amino group in the His-ligated heme enzyme tyrosine hydroxylase, clarifying its catalytic role via substrate analogs @UTSAChemistry @UTSASciences @ACScatalysis https://t.co/0rGhipjx0V

[The Welch Foundation @WelchFoundation]

The Welch-funded project at @UTSAChemistry, led by PI Aimin Liu (@Dr_Feradical), has resulted in a new publication in the high-profile chemistry journal Angewandte Chemie. This work uncovers how the iron-containing oxindole-installation enzyme MarE shifts gears in oxygenation selectivity through structural and redox tuning, guiding distinct product outcomes from a shared substrate including the predominant dioxygenated product to the intended monooxygenated 2-oxindole scaffold for natural product biosynthesis. By revealing the true catalytic identity of MarE and delineating the roles of small-molecule effectors and loop architecture, this study advances mechanistic understanding and predictive capabilities within the oxygenase superfamily. https://t.co/PWZheXjdtV

[Metallobiochemistry lab at UTSA @FeRadLab]

New publication alert! Check out our findings on MarE chemistry and how our engineered loop-swapping between MarE (SLGGR) and TDO (GTGGS) showed the importance of its role in directing oxygenation outcomes! @angew_chem @UTSAChemistry https://t.co/JVAAEytc7v

[Aimin Liu @Dr_Feradical]

Proud to celebrate Ephrahime Traore and Romie Nguyen on earning their PhDs! 🎓✨
Watching you grow as scientists has been a true privilege. You’ve tackled tough experiments, late-night writing, and endless revisions!
Excited to see where science takes you next! Congratulations!

[Metallobiochemistry lab at UTSA @FeRadLab]

The world of enzyme catalysis is expanding! Ms Graciano & @Dr_Feradical highlight the increasing diversity of protein-derived cofactors, crucial for enzyme innovation. Read their review: https://t.co/KuBDD9D1Il #enzyme #biocatalysis #cofactor @UTSA @NSF @NIGMS @WelchFoundation

[Metallobiochemistry lab at UTSA @FeRadLab]

@Dr_Feradical wrote about KatG, highlighting how it dynamically regulates its cofactor and the unique position it has as a drug target. Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development @tandfonline https://t.co/x0WawO0YCV

[Metallobiochemistry lab at UTSA @FeRadLab]

@Dr_Feradical wrote about KatG chemistry, highlighting how it dynamically regulates its cofactor and its unique position as a drug target. Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development @tandfonline https://t.co/x0WawO0YCV

[Metallobiochemistry lab at UTSA @FeRadLab]

@Dr_Feradical wrote a review on KatG and its dynamic regulation and the unique position it has as a drug target. Full article: Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development @tandfonline https://t.co/aH4h7WRBI0

[Metallobiochemistry lab at UTSA @FeRadLab]

@Dr_Feradical wrote a updated review of KatG chemistry, highlighting dynamic regulation and its position as a unique drug target. Article: Catalase-peroxidase (KatG): a potential frontier in tuberculosis drug development @tandfonline https://t.co/aH4h7WRBI0

[Metallobiochemistry lab at UTSA @FeRadLab]

Check out our new publication! Structural insights into 2-oxindole-forming monooxygenase MarE: Divergent architecture and substrate positioning vs. tryptophan dioxygenases https://t.co/6WpTeGbaSS @WelchFoundation @jbiolchem

[Metallobiochemistry lab at UTSA @FeRadLab]

Whoa, hey there boss! Your innovative ideas and consistent support puts your students (us!) in optimal conditions to thrive. We are very happy to see UTSA recognize your efforts! @UTSAchemistry @UTSASciences @UTSAtoday https://t.co/aGJeOMBs3o

[Metallobiochemistry lab at UTSA @FeRadLab]

Excited to share our new publication in JBC on the enol/keto tautomerization of oxaloacetate by ACMS decarboxylase (doi: 10.1016/j.jbc.2024.107878)! This finding highlights the need for further biological testing. #ACMSD #enzymology #Oxaloacetate #metabolism

[UTSAChemistry @UTSAChemistry]

Congratulations to UTSA Chemistry’s Yu Yung, Ian Davis, and Dr. Aimin Liu on their published article in the Journal of Biological Chemistry about “α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase catalyzes enol/keto...” Be sure to check it out! https://t.co/HVg75H9HLc

[Metallobiochemistry lab at UTSA @FeRadLab]

Temperature is an important factor for pathogenic protein. See how KatG regulates its activity by an N-OOH adduct and uses its MYW cofactor to direct its oxidizing power towards peroxide decomposition rather than peroxidase activity @angew_chem @UTSA

[UTSAChemistry @UTSAChemistry]

Congratulations to UTSA’s Chemistry Jiasong Li, Ran Duan, Ephrahime Traore, Romie Nguyen, Ian Davis, Wendell Griffith, and Aimin Liu on their publication in Angewandte Chemie International Edition (ACIE) about “Indole-N-Linked Hydroperoxyl Adduct of...” https://t.co/tNAtp5yVSH

[Aimin Liu @Dr_Feradical]

New NIH grant! Join us to study amino acid metabolism, oxidation, crosslinking by metalloenzymes using Chem Biol, site-directed incorporation of noncanonical amino acids, spectroscopy, crystallography, and cryoEM (https://t.co/gNlOfU6YrU; contact: [email protected]) #ScienceJobs

[Metallobiochemistry lab at UTSA @FeRadLab]

We were very happy and honored to have lab alumnus Capt. Ian Davis join us for a dinner with the whole group. It was great to hear about your new work and life experiences and know that you are thriving, Ian! @GeorgiaStateU @UTSA @UTSAChemistry

[Metallobiochemistry lab at UTSA @FeRadLab]

The Liu lab Summer2024 pickleball competition was a great success. Our students need to work harder to improve their pickleball skills since @Dr_Feradical gave no quarter and decisively won! Can't let this happen again... @UTSAChemistry @UTSA @UTSASciences

[Metallobiochemistry lab at UTSA @FeRadLab]

ADO is pivotal in the regulation of oxygen sensing and thiol metabolism. We present evidence of a catalytic metal(3+)-bound superoxo intermediate, challenging the status quo of a high-valent ferryl intermediate in the thiol dioxygenase mechanism @J_A_C_S https://t.co/vCvAAqmVrq

[Metallobiochemistry lab at UTSA @FeRadLab]

Rest in peace, Dr. Jarzecki

[Aimin Liu @Dr_Feradical]

Very sad to learn that Prof. Andrzej A. Jarzecki @CCNYChem, our collaborator on catalase-peroxidase (i.e., KatG), passed away in an accident. He was a wonderful, friendly, knowledgeable, productive, proactive, and passionate colleague. May he rest in peace!

[Metallobiochemistry lab at UTSA @FeRadLab]

Congrats Cassadee Stagliano, for passing your candidacy exam with flying colors! We're excited to hear about your future discoveries in the heme enzyme field @UTSA @UTSASciences @UTSAChemistry