Emeritus Professor, Sorbonne University Medical Faculty. Former Director Cordeliers Research Centre. Metabolic physiology. Liver metabolism. Type 2 diabetes
New in JBC press: "Scientists' study highlights for the first time that C2-ceramide (C2-cer) induces a loss in insulin sensitivity through the salvage/recycling pathway in muscle cells."
Learn more:
https://t.co/RF0XbnMwLM
Excited to publish our team's work in @jbiolchem which shows how ceramides can be recycled in muscle cells.
Ceramide analogue C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway https://t.co/1vuOOI80rk
@DanielJDrucker@PNASNews We published in 1989 a paper in the Biochemical J. (262, 881-886) showing in obese Zucker rat and using 2-DOG that the Hypoglycaemic effect of metformin results from an increased utilization of blood glucose by intestine. This was particularly true in hyperglycemic conditions.
@StephenORahilly May I add the huges progresses made for treating the 400 millions diabetic subjects and diabetes complications such as cardiovascular diseases!!!
@StephenORahilly@IMS_MRL Oxford is a great memory. I spent two years there as a postdoc in Krebs lab working with D.H Williamson, a wonderful biochemist and man, with meetings bringing together H Krebs, D. Williamson, P Randle and sometimes E Newsholme, with R Turner around. What an amazing environment!
@StephenORahilly Thanks Steve for your nice comment. The paper you mention got relatively unnoticed at the time but we were later glad to see that radiologists recommand to stop metformin for the detection of intestinal tumors by PET scan since it masks high glucose utilization by the tumor!
Jean-Paul (right) and myself entered Jean Girard (left) ‘lab in 1975 and work with him for many years on metabolism during development. We have just celebrated our 80th and 70th birthdays together. Science can be such a humane and friendly adventure!