Brian Finrow

Founder/CEO at Lumen Bio. I'm a quasi-outsider to the biopharma industry, interested in the economics of drug development.

[Brian Finrow @Finrow]

Uncommon results like this are commonplace at Lumen Bio.

Requires a team with uncommon talent — talented people like YOU!

Join us! Especially — right now — if you have a passion for clinical trials or assay qualification/validation.

[Lumen Bioscience @LumenBio]

Promising news for C. diff patients! 100% of patients with LMN-201 + antibiotics successfully resolved their primary infection, and 95% of participants had no recurrence within 28 days (RePreve Trial sentinel cohort results). https://t.co/u0UZJWFJcP #PatientCare #Clinicaltrial

[James Pethokoukis ⏩️⤴️ @JimPethokoukis]

'The surge in new US business formation is being fueled by AI and large language models, which are dramatically reducing the cost and complexity of launching a company' @apolloglobal

[Melinda B. Chu @MelindaBChu1]

Something that is underappreciated is China has 4x the population and Tier 1 cities are 30 million people, so easier to recruit and finish studies.

However, their Phase 1 process is more like Australia and have more silent approval; if you don’t hear from us, proceed. Australia is fast for Phase 1 and they have more silent approval, but they are just doing safety and know the pivotal trials will primarily be done in US & other countries.

FDA tends to view Phase 1 as precedent for the entire drug program all the way through Phase 3, so they want everything to be in order from the start like CMC.

I would say Australia doesn’t really care about CMC b/c that will be covered by US during trials and scale up. For Phase 1 just need smaller batch manufacturing, do not necessarily need to be set up with standards for Phase 2 or 3 larger trials, but it makes thing smoother.

[owl @owl_posting]

bleak that the primary people who are worried about chinese biotech are people who actually work in the field, and everyone telling them to chill out are either VC’s or journalists

[Dr. Marty Makary @DrMakaryFDA]

We’re deeply committed to reforming our IND/Phase 1 process.

We must retain our position as the world leader in biotech.

[Crémieux @cremieuxrecueil]

A real downside of the rise of LLMs is that we now have to sit through Cloudflare verification pages all the time.

[Zechen Zhang @ZechenZhang5]

1/ For nearly 350 years, science has communicated itself through one object: the paper. A linear narrative, frozen as a PDF, written for a human reader. We've come to treat that format as the medium of science itself.
It doesn't have to be. It's a historical artifact. 🧵

[Cairo Smith @cairoasmith]

There's a common misconception that Brutalist buildings were unpainted, but thanks to microscopic analysis of the exteriors we can now recreate what they looked like in their prime.

[Hunter📈🌈📊 @StatisticUrban]

Wealth permits a morality to exist that would be incomprehensible to our ancestors.

E.g. Germany yesterday finally captured the stranded whale whose story had gripped the nation, and is now escorting him via barge back to the deeper Atlantic. An enormous, multiday operation.

[Brian Finrow @Finrow]

@CloisterRes There's a literature on everything
https://t.co/nthP8SIMvT

[Terence Shen @Terenceshen]

The dream of China surpassing the U.S. as the world’s largest economy is fading. In 2021, China’s GDP was about 78% of the U.S.; by 2024, that share had fallen to roughly 64%, back to around 2017 levels, with the gap between the two economies doubling in just a few years.

[Edward N Luttwak @ELuttwak]

There is more high tech in Israel than in Italy w x 6 the population because rich Israelis invest in the risky projects of young Israelis while rich Italians more prudently demand safer investments. The result of all that prudence is a terrible stagnation that pols ignore

[Winston @ChurchillWw]

US manufacturing capacity has shown solid growth for 16 consecutive quarters, indicating a consistent trend.
This is the first sustained expansion of US manufacturing capacity in nearly two decades.

What makes it more interesting is that many of the sectors leading the expansion are those that feed back into production itself: business equipment (+4.6% YoY), machinery, electrical equipment, fabricated metal, and computer and electronic products.
https://t.co/sSYagpp85O

[Seth Bannon @sethbannon]

VC is becoming more and more like momentum trading -- investing big amounts in things already working.

But VC at its best is about giving the underestimated outsider a chance to change the system for the better, even though the odds are against them. We must not lose that!

[Derek Thompson @DKThomp]

It’s interesting how many aspects of modern political commentary hold up the 1945-1971 postwar period as the natural state of things that was broken by our weird new modernity, when instead maybe it’s more accurate to see this period as profoundly unusual.

I think about this with media commentary all the time: “Why can’t we get back to Walter Cronkite, shared sense of reality, etc”

A brief and strange information oligopoly created a scarce number of radio/TV stations, which enforced a news monoculture on radio/TV audiences. Whether that was altogether good or bad, it was extremely weird! Look at the 19th century. A zillion newspapers, many of them insane and terrible and partisan. The chaos is what’s normal.

[Dean W. Ball @deanwball]

The Industrial Revolution would not have happened if it had begun amid our current institutions, political economy, and level of regulation/procedural roadblocks aka “democratic input.” This is among the starkest challenges facing Western society today, though uncouth to discuss.

[Brian Finrow @Finrow]

@rtnarch …but obviously a statutory change would be clearer and more permanent so great news, it if passes…

[Brian Finrow @Finrow]

@rtnarch Not even necessary for Congress to act—the agency already has the power it needs to do this tomorrow morning.

They too “can just do things.”
https://t.co/bOk0cNEfSB

[Brian Finrow @Finrow]

@cremieuxrecueil Many such buttons lying about, it seems

https://t.co/bOk0cNEfSB

[Brian Finrow @Finrow]

@varma_ashwin97 @Banana_Oncology @DrPaulyDeSantis You and me both, brother