galante_lab

Pedro Galante's Lab: Gene expression regulation, mobile elements, cancer targets, and bioinformatics tools.

[galante_lab @GalanteLab]

Finally, it's super cool that our paper was picked up by non-scientific media, both nationally and internationally!
https://t.co/BxHRG6RAB4
https://t.co/BW0uBYgMNJ

[galante_lab @GalanteLab]

Excited to share high-quality genomes for sloths and anteaters and some amazing mammalian biology findings! 🦥🧬 https://t.co/FeZQOyYwnL

[galante_lab @GalanteLab]

Very proud of this work, we’re now investigating the impact of active L1s in sloths and the functions of these domesticated retrocopies. Huge thanks to all collaborators who contributed to this project, and to the excellent opportunity for our lab to participate in this research.

[galante_lab @GalanteLab]

I'm pleased to share our recent review in Molecular Cancer Research, which examines the relationship between L1 activation and endocrine-related cancers. Many thanks to Rafael Loch's group for the excellent collaboration.

[Molecular Cancer Research @MCR_AACR]

Now online: LINE-1 Activation in Endocrine-Related Cancers: Molecular Mechanisms and Translational Implications https://t.co/h1hHkwJjLu

[galante_lab @GalanteLab]

We extend our heartfelt gratitude to all team members and collaborators who contributed to advancing our understanding of transposable elements and their role in human health. Your dedication and insights continue to drive progress in this exciting field. 🙏🔬

[galante_lab @GalanteLab]

We are excited to share our latest paper, where we review the role of endogenous retroviruses in our genomes.
Read the full story of "Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation" here: https://t.co/mMNKTsJy1X

[galante_lab @GalanteLab]

Therapeutic potential unlocked: HERV reactivation (via DNMT inhibitors) can induce “viral mimicry,” boosting antitumor immunity & enhancing immunotherapy. They’re not just genomic fossils—they’re emerging biomarkers and immunotherapeutic tools. #Immunotherapy #PrecisionOncology

[Agência FAPESP @AgenciaFAPESP]

Pesquisa desvenda como alguns tipos de #câncerdemama ‘driblam’ tratamento. Descoberta aumentou de 13 para 90 o número de variações conhecidas da proteína HER2, alvo de medicamentos avançados contra a doença; diversidade pode explicar resistência a terapias https://t.co/W2P0ycRSar

[galante_lab @GalanteLab]

What makes us human? We are happy to be able to contribute to this fantastic work that helps us understand how environmental exposures may have contributed to shaping the brains of hominids. Thanks to our wonderful collaborators for the opportunity.

[Science Advances @ScienceAdvances]

Hominids experienced lead exposure as far back as 2 million years ago, new research finds, challenging the theory that the neurotoxicant is an exclusively modern health hazard. https://t.co/a7jNR48OJp

[galante_lab @GalanteLab]

📚 Want to know more?
Check out the full preprint to dive into the details of how retrocopies are shaping the genomic evolution of xenarthrans!
https://t.co/wE1C3yeLxu
#Genomics #Evolution #Xenarthra #Sloths #Retrocopies #VGP #Science 🧬🦥🔬

[galante_lab @GalanteLab]

🚨 New preprint alert! 🧬
We’re excited to share our latest collaborative work on the genomic evolution of xenarthrans (sloths, anteaters, and armadillos)! We discovered that these animals have the highest number of retrocopies ever reported in mammals. 🦥🦔

[galante_lab @GalanteLab]

👏 Special thanks:
This work was made possible by the collaboration of many researchers and the incredible support of the Vertebrate Genomes Project (VGP), which produced high-quality genomes for xenarthrans. Thank you to everyone involved! 🙌