Gantier Lab

Prof Michael Gantier's lab @Hudson_Research studies the immunology of nucleic acids (such as mRNA therapeutics)

[Gantier Lab @GantierLab]

Ever wondered what happens to oligonucleotide therapeutics once they start to break down? In our new bioRxiv preprint, we provide a molecular dissection of how chemically modified 3‑base oligonucleotide fragments engage TLR7 and TLR8. Check it out! https://t.co/gndM4qCzlB

[Immunology Podcast @ImmunoPodcast]

Researchers led by Drs. Michael Gantier (@GantierLab), Toshiyuki Shimizu, and Ben Corry (@CorryLab) show that modified #RNA from our own cells naturally blocks TLR7 and TLR8, preventing harmful immune activation.

📖: https://t.co/7PqpIURTMG
🔊: https://t.co/9WF95DtNbw

[Gantier Lab @GantierLab]

https://t.co/qBf5kU1RmZ

[Human Immunology News @humanimmunenews]

Recognition of RNA fragments by TLR7 and TLR8 helps to initiate the innate immune response.

This work redefines TLR7 and TLR8 sensing by introducing 2′-OMe guanosine as a natural immune checkpoint for their activation. @NatImmunol

🔗 https://t.co/C1ZymIb20y

[Gantier Lab @GantierLab]

@sciencescanner @3DiMMUNE We don't know yet. However it is conceivable that receptors such as TLR7/8 needed a built-in off-switch in their LRRs, and that it would have then evolved as a sensing mechanism when nucleic acids accumulate.

[Gantier Lab @GantierLab]

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > https://t.co/Kh8y8C8pMw

[Corry Lab @CorryLab]

How does your immune system tell pathogenic RNA from your own, even though they’re made of the same stuff? Our latest paper with
@GantierLab
shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. 🧬🔬⭐ https://t.co/GyNvzuVaJj

[Gantier Lab @GantierLab]

@3DiMMUNE We propose it is the accumulation of agonistic fragments (short RNAs and nucleosides which work cooperatively) which outcompetes the basal natural antagonism.

[Molecular Therapy Family of Journals @MolTherapy]

IsomiR stoichiometry changes as disease biomarkers. https://t.co/CBrpZlrf89 #MTNA

[Gantier Lab @GantierLab]

Excited to share our latest work on how microRNA length variants can be leveraged as disease biomarkers. Congratulations to Alex McAllan for all her work on this!
https://t.co/GIb9rvYiHU

[Gantier Lab @GantierLab]

For all RNA scientists in the Melbourne area: Join us at the next RNA Victoria Minisymposium on 27th of March at the Hudson Institute of Medical Research - details about the speakers and free registration at https://t.co/7mtGOwNT5A

[Gantier Lab @GantierLab]

Follow us on https://t.co/xoFDgq8Jg3

[Gantier Lab @GantierLab]

Please mark your calendars for the next RNAVIc symposium. It will be July 22nd at WEHI Davis Auditorium starting at 2pm. https://t.co/7mtGOwOqV8

[Hudson Institute of Medical Research @Hudson_Research]

We are thrilled to announce the official launch of the #RNAte Platform at @Hudson_Research, delivering huge advances in the development of #mRNA-based therapies. 🥳💪🏽

Read more about this revolutionary platform: https://t.co/uYc1LD40vc

@VicGovAu @VicGov_DJSIR

[Hudson Institute of Medical Research @Hudson_Research]

We recently welcomed Deputy Premier & Minister for Medical Research, The Hon @BenCarrollMP to Hudson Institute! 🙌

Minister Carroll went behind the scenes with some of our researchers, including our CEO & Director Prof Elizabeth Hartland, to learn more about our research.🔬

[seth masters @sethmasters]

@Hudson_Research @CiiiD_Hudson Thrilled to be joining longtime friends and colleagues @CiiiD_Hudson including those I could find on twitter @ProfHartland @FerreroMicro @Tate_Lab @GantierLab @pjhpauljh @Forster_Lab @PhilBardin

[Gantier Lab @GantierLab]

@pjhpauljh Congratulations Dom!!!

[Gantier Lab @GantierLab]

@Labo_Pepin Congratulations Genevieve and the entire team!!!

[Labo Pépin @Labo_Pepin]

Exciting data to build our research program on thromboinflammation! So proud of this first research paper! Thanks to the many students and collaborators who contribute to this story! https://t.co/B8eDGLfETn

[Jeremy J Barr @JeremyJBarr]

Our latest work, out today in @PLOSBiology suggests that not only do mammalian cells absorb bacteriophages, but they appear to use them as a resource to enhance growth!

https://t.co/6oGAXcD4Jp

This work was led by @marion_bichet and out on World Phage Week! #WorldPhageWeek