Laboratory of Gene Therapy

By using advanced molecular techniques, we try to develop therapeutic strategies targeting toxic RNAs in diseases like FXTAS and DM

[Laboratory of Gene Therapy @GeneTherapyLab]

Check out our newest paper out @NatureComms demonstrating that short antisense oligonucleotides #ASOs alleviate the pleiotropic #toxicity of #RNA harboring expanded #CGGrepeats! @UAM_IBMiB #FXTAS #Rloops #miRNAbiogenesis #AlternativeSplicing #FirstTweet https://t.co/TnD6oj1I6Y

[Laboratory of Gene Therapy @GeneTherapyLab]

PhD position call!
Are you a motivated researcher, interested in molecular biology? If so, we have an exciting project for you elaborating the functions of MBNL splicing regulators. Deadline - 26th of June.
Applications & more info - K.Taylor, PhD; [email protected]
@UAM_IBMiB

[Laboratory of Gene Therapy @GeneTherapyLab]

Happy to share our latest review gathering information about RNA binding proteins implicated in RNA repeat expansion diseases.
#RNA, @UAM_IBMiB_PL
https://t.co/usH3YypC7P

[Laboratory of Gene Therapy @GeneTherapyLab]

Check out our new publication https://t.co/lnqj0coFdd published in @SciReports where we described the distribution of alternative untranslated regions within the mRNA of the #CELF1; good job @ArekPKajdasz D.Niewiadomska @MichalSekrecki and K. Sobczak @UAM_IBMiB #DM1 #splicing

[Laboratory of Gene Therapy @GeneTherapyLab]

Big congrats to our lab member Katarzyna Taylor and others, who recently received Sonata grant from #NationalScienceCentre. Kasia is going to deeply investigate #MBNL #splicing and a potential therapeutic strategy for #myotonicdystrophy work will be done at @UAM_IBMiB

[IMBB AMU Poznań @UAM_IBMiB]

5 #NCN grants - 9.3mln zł (~2mln €) awarded to @UAM_IBMiB researchers!!! Congratulations to Zofia Szweykowska-Kulinska, Małgorzata Borowiak, Mikołaj Olejniczak, Katarzyna Taylor @GeneTherapyLab & Jakub Dolata @JakubDolata86! #NationalScienceCentre @UAM_Poznan @zuniwersyteckie

[Laboratory of Gene Therapy @GeneTherapyLab]

Today, member of our lab @MichalSekrecki successfully defend his PhD! Congrats and all the best!

[Michal Sekrecki @MichalSekrecki]

Time flies by. Six years ago I started my PhD @UAM_IBMiB @GeneTherapyLab Today it was my defence and it went even better than I could imagine 👌 a lot of good things happened during this time. Now I'm looking forward to new challenges! #PhDone

[🔬 R-loop @R_loop_papers]

Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats https://t.co/ayfbc1AZkA

[Laboratory of Gene Therapy @GeneTherapyLab]

Many thanks to our collaborators @huukje and @OliverStork from @OVGUpresse !! #collaborationcelebration 🥳🤝

[Laboratory of Gene Therapy @GeneTherapyLab]

Check out our newest paper out @NatureComms demonstrating that short antisense oligonucleotides #ASOs alleviate the pleiotropic #toxicity of #RNA harboring expanded #CGGrepeats! @UAM_IBMiB #FXTAS #Rloops #miRNAbiogenesis #AlternativeSplicing #FirstTweet https://t.co/TnD6oj1I6Y

[Laboratory of Gene Therapy @GeneTherapyLab]

In this paper we describe an antisense oligonucleotide (ASO)-based therapeutic strategy for fragile X-associated disease. We showed long-lasting effect of ASO treatment which suppress the dominant negative effect of toxic RNA of mutant gene in brain of mouse model of the disease

[Laboratory of Gene Therapy @GeneTherapyLab]

Check out our last paper done @UAM_IBMiB
We show that MEF2C #transcriptionFactor shapes the #miRNA transcriptome during differentiation of #skeletalMuscle
@SciReports Many congrats to Agnieszka Piasecka,
@MichalSekrecki
, Michal Szczesniak & Krzysztof Sobczak!!!

[Michal Sekrecki @MichalSekrecki]

Finally our study about the impact of MEF2c on microtranscriptome in skeletal muscles is out! Read our work in @SciReports
https://t.co/UAmTN1UAoN
A great work done in @GeneTherapyLab lead by @KrzysztofSobczak at @UAM_IBMiB