George Spracklin

[Nezar Abdennur @nv1ctus]

Hot off the press 🔥!
@GeorgeSpracklin, Max Imakaev, @ChowdhuryNeil, @leonidmirny, @job_dekker, Sriharsa Pradhan @NEBiolabs @MIT_IMES @UMassChan
👇
https://t.co/bJToy1S9YI

[Open2C @Open2C_team]

If you do #3Dgenome data analysis in #python, check out cooltools (https://t.co/AZLBWTbdIZ): now preprinted at https://t.co/loHv0CirMN
1/8

[Jeremy Owen @jeremyaowen]

1/ How do cells remember their cell type? Could one function of 3D genome folding be to help sustain this epigenetic memory? You heard my talk last week at #cshlepich22, now our preprint is out! https://t.co/EINFjaSGiq

[Leonid Mirny @leonidmirny]

Are chromosomes memory machines? We just posted a @biorxivpreprint with @jeremyaowen and Dino Osmanovic showing how 3D genome organization can help stabilize epigenetic information.

[Nezar Abdennur @nv1ctus]

Extremely proud to announce the opening of the Abdennur lab at @UMassChan! 🎉🎉🎉

We’re an interdisciplinary computational group solving big challenges in multiomic data science. 🧬📊

[Geoff Fudenberg @gfudenberg]

If you are interested in developing computational approaches to understand 3D genome organization, get in touch!

[Nezar Abdennur @nv1ctus]

My slides on @Open2C_team's #bioframe package for genomic interval operations with #pandas from #SciPy2022.

https://t.co/uZ3mH0ogsl

If you do bioinformatics in #Python, you should give it a whirl!

And a little announcement at the very end. More info on that to come :)

[Open2C @Open2C_team]

We are a group of computational biologists working on genome architecture developing open source tools for the wider community. https://t.co/XhFSSIio1q Sergey Venev, @nv1ctus, @gfudenberg, @golobor, @Phlya, @agalitzina, @GeorgeSpracklin, Sameer Abraham, Maxim Imakaev and others

[George Spracklin @GeorgeSpracklin]

Working with a great team of organizers on @KeystoneSymp #eSymposia, Higher-Order #Chromatin Architecture in Time and Space, tune in to explore emerging #epigenetic research and interactive networking opportunities. https://t.co/etyfBIHDx8 #VKSChromatin22

[Aleksandra Galitsyna @agalitzina]

Our solo review on single-cell Hi-C is out!
https://t.co/VIoiyZAAhX

[NatureStructMolBiol @NatureSMB]

On the cover of our August 2021 issue, we highlight recent work by Brandão, Ren, @xindanw @leonidmirny and colleagues reporting beautiful Hi-C plots resembling historic tiles. Check out the full issue here:
https://t.co/RZ6c9aMmut

[PromisingPreprints @PromPreprint]

Heterochromatin diversity modulates genome compartmentalization and loop extrusion barriers
https://t.co/uUUJgzR5GS

[Anne-Laure Valton @AnneLaureValton]

We are thrilled to share our new manuscript preprint: A cohesin traffic pattern genetically linked to gene regulation.
Fantastic collaboration with @athmapai and Jason Moffat groups.
https://t.co/AfTD7eyulk

[Leonid Mirny @leonidmirny]

Heterochromatin, DNA methylation and loop extrusion -- are all intertwined -- new preprint from our team led by @nv1ctus and @GeorgeSpracklin. The first molecular perturbation that changes compartments!

[Anton Goloborodko @[email protected] @golobor]

this is a *really* interesting study on the types of genomic compartments and mechanisms behind their formation (I'm biased, though)! one of unexpected findings for me was the big difference between H3K9me3 and H3K9me2+H2A.Z chromatin.

[Nezar Abdennur @nv1ctus]

Very excited to announce our preprint on heterochromatin and genome architecture! With @GeorgeSpracklin , Max Imakaev, Neil Chowdhury, @leonidmirny @job_dekker and Sriharsa Pradhan @NEBiolabs. https://t.co/7gh0pLCZRY

[George Spracklin @GeorgeSpracklin]

@nv1ctus @leonidmirny @job_dekker @NEBiolabs And our great mentors Sriharsa Pradhan, @leonidmirny @job_dekker

[Leonid Mirny @leonidmirny]

We just posted a very important paper on #cancer #immunotherapy with @carino_dg. Widely believed and #FDA-approved biomarker of response - the total number of mutations in cancer (mutational burden) is bogus. We reanalyzed all data - no statistic significance #DataScience

[bioRxiv @biorxivpreprint]

Limited evidence of tumour mutational burden as a biomarker of response to immunotherapy https://t.co/7XVVrz1zMh #bioRxiv

[George Spracklin @GeorgeSpracklin]

@NAR_Open and a huge thanks you to @NEBiolabs for supporting the project!

[George Spracklin @GeorgeSpracklin]

forgot to tweet this....Protect-seq paper is out!!! great experience @NAR_Open https://t.co/97osN5o8j0