Gerhard Koenig

CEO & Founder @arkudatx, biopharm entrepreneur @atlasventure, #immigrant, opinions are my own

[Gerhard Koenig @GerhardKoenig1]

Nice coverage of #Arkuda #ADPD2023 presentation by Raymond Hurst.

[Gerhard Koenig @GerhardKoenig1]

Great presentation by our own Raymond Hurst #ADPD2023

[Gerhard Koenig @GerhardKoenig1]

Another study showing that loss of function of #TDP43 plays important role in #Alz. Excellent science from Don Clevelend's group. https://t.co/kgw90ZkCxH

[Gerhard Koenig @GerhardKoenig1]

Adaptive immunity might play a role in tau toxicity in @alzdisease . Mice with depleted #T-cells are protected from #neurodegeneration. See https://t.co/NiSWASWcNQ

[ARKUDA Therapeutics @ArkudaTx]

Happy #IWD2023!
Today and every day we celebrate the incredible achievements of women in different aspects of life all over the world.
#EmbraceEquity

[Gerhard Koenig @GerhardKoenig1]

#WilliamUtermohlen has shown sad 'altered self' as he developed #AD. Another example how creativity /Art is changing in neurodegenerative diseases, here FTD https://t.co/yxjqQd67VP

[VIB @VIBLifeSciences]

Great news! 📢 #VIBspinoff #ConfoTherapeutics just signed a licensing deal with @LillyPad for the development of their drug candidate in #NeuropathicPain, a devastating condition caused by damage to the #nerves outside of the brain and spinal cord 👉 https://t.co/ikOtH9dZmW

[Gerhard Koenig @GerhardKoenig1]

Good assessment of the current debate…

[The Wall Street Journal @WSJ]

The success of Eisai’s new Alzheimer's drug Leqembi has helped quiet a debate on whether removing amyloid from the brain can aid in slowing deterioration. “It isn’t really a hypothesis anymore.” https://t.co/WrUSXIRGaB

[VIB @VIBLifeSciences]

👏 Congratulations to Ludo Van Den Bosch (@LuVaDeBo, @CBD_VIB) for winning the prestigious Generet Award for Rare Diseases (@KBS_FRB)! He will use the one-million-euro funds for research into motor neuron disease ALS.
Read more 👉 https://t.co/endCd4Csve

[The AFTD @AFTDHope]

Media alert: AFTD's CEO Susan Dickinson will be appearing on @NBCNightlyNews to speak about the Willis family's announcement. The show airs at 6:30 Eastern Time tonight in just a few minutes! #SupportBruceWillisFTD #EveryFTDStoryCounts

[The AFTD @AFTDHope]

Thank you for all you do and for elevating this story. #EveryFTDStoryCounts #EveryDementiaStoryCounts #SupportBruceWillisFTD

[Gerhard Koenig @GerhardKoenig1]

#benzodiazepines enhance synaptic pruning by #Microglia . See Nature Neuroscience report by She et al. https://t.co/7lUEuLhmft. Might explain memory lapse in the morning after you took benzos. https://t.co/IgSOQ0ytEh

[Gerhard Koenig @GerhardKoenig1]

This needs no comments

[CSPAN @cspan]

Ukrainian Ambassador to the @UN @SergiyKyslytsya reads text messages between a Russian soldier and his mother moments before he was killed.


"Mama, I'm in Ukraine. There is a real war raging here. I'm afraid. We are bombing all of the cities...even targeting civilians."

[Gerhard Koenig @GerhardKoenig1]

Glad to share that series B investors recognized the high quality science & potential in #Alzheimer #FTD #Parkinsons as well as beyond #neurodegeneration going forwardhttps://t.co/CFA9fxNHxi

[King Baudouin Foundation @K_B_Foundation]

Generet Prize for Rare Diseases: one million euros for Prof. Rosa Rademakers to continue her research into a rare form of dementia. Congratulations!
https://t.co/3dMxipzj22
@VIBLifesciences @ditisVIB @CMN_VIB @UAntwerpen @RademakersRosa

[Gerhard Koenig @GerhardKoenig1]

Previous post was "mutated". Correction here: It is all about the ratio of Abeta peptides in #FAD. Study shows that more of the shorter #Abeta forms has patients decline slower in #Alzheimer.

[Gerhard Koenig @GerhardKoenig1]

It is all about the ratio of Mutations in gamma-secretase in #FAD and https://t.co/Zj40LrDK4R. Study shows more of shorter #Abeta forms has patients decline slower in #Alzheimer. Rationale for a disease modifying approach of positive allosteric modulators for gamma secretase.

[Gerhard Koenig @GerhardKoenig1]

#GWAS https://t.co/Po1LT8KXK0 found new risk factors #BIN1 and #TMEM117 for #Dementia with #Lewy bodies (#DLB)- the neurodegenerative disease #Robin Williams struggled with. #lysosomal and #Microglia implied. #Alzheimer -@ DLB -@Parkinson contiuum https://t.co/t2xJyhv1PU

[Gerhard Koenig @GerhardKoenig1]

Lipids & lysosomes. Just out in bioRxiv. January 20, 2021 by Xia D. et al. APP mutation models with increased 'face validity' via knock-in. Lipid metabolism & lysosomal activity involved in early pathology. https://t.co/ymnzkeqQT0

[Gerhard Koenig @GerhardKoenig1]

Removal of aggregated pyroGlutamate, a post translational modification of #amyloid beta, with #mAb from Eli Lilly and Company shows promise in mild #alzheimer in phase 2 trial. Eagerly awaiting publication to read more details about clinical effects! See https://t.co/mEEnlRKT7t