The real implications of this impressive work is to why we make these autoAbs? This supports a physiological role @casanova_lab
Transient anti-IFN autoantibodies in the airways are associated with recovery from COVID-19 | Science Translational Medicine https://t.co/QL8qEM9THI
In some cases, autoantibodies can actually protect you during infection 🤯. Fascinating meticulous study by @EliverGhosn in @ScienceTM about anti-IFN IgA in #COVID19, which could change our general perspective on autoimmunity: https://t.co/YoXhlmvbOU
There's always something worth celebrating in the lab. This week it's our traditional lab competition: the cookoff. Congratulations to this year's "chef laureates" Krishna Kothari and @EliverGhosn! Runner-up recognition to @bazzano_julia, Justin Hahm and Collin Leese-Thompson.
NOSE ANTIBODIES may help REGULATE the IMMUNE RESPONSE and promote RECOVERY against COVID-19
An amazing study 💯👍
Thanks to @DavidJoffe64
https://t.co/c32BwcGgqT
So, so proud to see our work read and discussed.
This came together as a beautiful story describing an unexpectedly beneficial autoreactive antibody response in the nose during COVID-19.
Thanks @GhosnLab and @EliverGhosn. Summary below and more here: https://t.co/OBNpogSYvP
#News New @EmoryUniversity research highlights the therapeutic potential of an enzyme in managing immune-related disorders. Eric Sundberg, professor and chair in the Department of Biochemistry at @EmoryMedicine, was principal investigator on the study. https://t.co/dRMdSopFgJ
New research from Emory University is providing a more precise prediction of COVID-19 severity that can be found by looking at autoantibodies in the nasal cavity.
➡️ Details: https://t.co/Gn2y1KY2oH
This is such an important paper from @EliverGhosn @GhosnLab which I really hope is the start of how we collectively begin to appreciate the importance of the relation between isotype/subtypes of antibodies produced, beyond the antigen they target, whether a self epitope or not.
The 2 sides of autoantibodies to interferon-α, like a rheostat
—Pre-existing in the blood: linked to high risk of life-threatening Covid
—Induced by #SASRCoV2 in the nose, airways mucosa: Protective
https://t.co/bugYYjJrez @ScienceTM @EliverGhosn @GhosnLab@ben_r_babcock
The @GhosnLab, @EliverGhosn and our collaborators from Emory/UCSF/Gladstone showed that transient autoantibodies against type-I interferon (IFN) are a common feature of the SARS-CoV-2 response, and are associated with efficient COVID-19 recovery. https://t.co/IWDWRAaoLb 2/
The epithelium of the nasal mucosa is the initial site of SARS-COV-2 exposure and infection. As such, antiviral immune responses mounted locally in the nasal mucosa can play a role in determining disease recovery or progression to severe COVID-19. 1/
We often think of autoantibodies (anti-self) as flaws in immunity which lead to more severe viral infections, like COVID-19. @GhosnLab and collaborators show anti-interferon autoantibodies associate with recovery from COVID with less severe symptoms. How could this work? 1/Thread
The winning dishes in each category were kibbeh with fresh hummus (Eliver) and pumpkin pie bars with homemade ice cream (Alex). Both were at the top of a VERY crowded field. Congratulations!