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When life gives you lemons, grow a tree

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@photobiogenesis It's pretty funny given the expected effect of caffeine vs beta-blockers on glucose regulation that the actual effect can sometimes apparently be the complete opposite. Caffeine is rarely by itself of course, but still.
https://t.co/hmRPgHjJdW

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@biohacker The gut microbiome metabolites are often exactly what you want, lot of low absorption phytochemicals are basically prodrugs for the right microbiomes. Just one example from EGCG, even just EGC-M5 seems to be quite good.

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@PGC1a_RB There are also just analogs of carnosine out there that resist degradation via carnosinase which could be quite useful. Bit harder to source most of them though. Balenine, Anserine, and the much lesser known (albeit easier to source) Carcinine

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@yurddlc2 It is not perfectly reasonable that all 8b will press red, but it is perfectly reasonable to believe that in a life-or-death stakes situation that half will not vote blue either.

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@Midgetfucked @untimelysalts I'm not happy or sad about it - it is just a thought experiment after all. Obviously, I'd be happy to preserve my more bleeding-heart friends/family.

All I've basically said is that it's a valid point to say that blue has not won in a way that should make red/blue happy/sad.

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@photobiogenesis I've been impressed with Mare and especially Donkey milk for quite awhile now, might be worth a look. Very high similarity to human milk relative to most other milks as well.

Just one particular example I found interesting: https://t.co/sWETiaoEJv

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@Midgetfucked @untimelysalts Do you earnestly think a little-to-no-stakes vote maps that closely onto a real life or death situation?

I am happy if the stakes are real and blue ends up winning, but I do not believe a simple internet poll can tell you if that would happen.

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@KuroSekaiAnime Red believes red will win when the survey includes everyone and the stakes are real. It is not selfish to believe this and choose accordingly. Doubly so if you believe it won't be close at all.

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@bLdsire @plasmarob It isn't usually a misunderstanding, rather a disagreement about the average person's nature in such a situation vs the result of some little-to-no stakes internet poll.

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@PGC1a_RB Has a bizarre response curve, way way higher and it can be weirdly stimulating for some people.

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@photobiogenesis @BottleBell @TakeThiamine Equid milks are perhaps even better in quite a lot of ways, though I think more people find the idea of goat milk palatable over donkey/mare/etc they're obv less accessible than goat milk.

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@Lukealexxander @esoteric_HODL @NoahRyanCo KW-6356 either that or another H3 antagonist/inverse agonist like Irdabisant. Someday when it becomes more widely available a orexin agonist perhaps.

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@AbudBakri @DrPatrick HAMLET/Alpha1H also impressive, Anktiva looks awesome, but hope those two start getting some more attention as well as they also have a lot of broad potential.

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@SSavson People would really benefit from reading some of the loading dose papers out there, some pretty amazing results with little apparent detriment.

There's a lot to gain in many cases even if it's obviously not on par with the sun.

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@ultimape We don't even strictly know how they're made in living organisms afaik. Gut microbiome probably plays a role, but we don't really know what you need to drive more of any of the particular compounds.

Nor do all of them even seem to work orally from the people I've talked to.

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@ultimape In extremely tiny amounts, but yes. That's the reason many of them are outright synthesized now excepting the mixes(like cerebro).

That said there are almost 100% many we don't know about and glandular therapies def didn't come about about for no reason.

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@martyrmade @NickJFuentes He still glows, so no

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@BowTiedGatorDDS Think the baked in assumption is that we'll fix all that stuff along the way since it's included in aging.

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@rcsprouljr When the land pays for basically 0% of that 37 Trillion I don't really care

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@PGC1a_RB I'm not sure such doses are liable to actually do much, do you know of any animal studies where the effective dose(s) don't translate to immensely larger human doses?