Glut4Science

🚴🏼‍♂️ Physiology, Metabolism, Nutrition, and Sport🍒 🧬 “From science to practice” 📩 [email protected] 👨🏻‍💻 By @MVAitor

[Glut4Science @Glut4Science]

New carbohydrate intake recommendations for endurance sports. 🚴🏼‍♂️🎿🏃🏽‍♂️

Based on:
- What science says about it 👨🏻‍💻
- Our field-research findings ✅
- What best athletes in the world currently do 🏆
- Our experience and everyday work with professional cyclists 🚴🏼‍♂️🚴🏼‍♂️

@MVAitor #carbs

[Glut4Science @Glut4Science]

FREE WEBINAR!! Sign up!

[Aitor Viribay @MVAitor]

Join me on this FREE WEBINAR!!

I´ll talk about Exogenous Lactate, the science behind it and potential solutions that are coming on the fuelling field!!

You can sign up here: https://t.co/PbApZ9dHLr

Hope to see you on the other side :) Thank you!!

[Aitor Viribay @MVAitor]

🎙️🆕 Episode: Lactate & Exogenous Lactate in Human Metabolism!

After years of research, I cover lactate metabolism, how exo. lactate may work, what we've tried with athletes & the gaps left to close.

Honored to build on G.Brooks' work. Thanks @DJ_Lipman!
https://t.co/Qo1U8Nhls4

[Aitor Viribay @MVAitor]

Interesting...

[Aitor Viribay @MVAitor]

Tilting your bed 6° head-up while you sleep may make your body produce more red blood cells. After 5 weeks, blood volume rose 4.1% - similar to what you'd get from altitude training. No change in those who slept flat. Small study (n=9), but intriguing!!

https://t.co/jniE0wGhtz

[Aitor Viribay @MVAitor]

Exogenous Lactate, the preferred energy substrate. New post in @Glut4Science after 3 years!!

I hope you can enjoy the read of our journey behind ExoLactate and the science behind this potential fuelling solution! 🤓

Thank you very much for reading!

https://t.co/h6lUmJ1wBs

[Jimmy Jazz @jaimeromosntmr]

Esto es absolutamente maravilloso.

[Glut4Science @Glut4Science]

New post in the blog!!

[Aitor Viribay @MVAitor]

Exogenous Lactate, the preferred energy substrate. New post in @Glut4Science after 3 years!!

I hope you can enjoy the read of our journey behind ExoLactate and the science behind this potential fuelling solution! 🤓

Thank you very much for reading!

https://t.co/h6lUmJ1wBs

[Aitor Viribay @MVAitor]

Re-reading this paper from some years ago. I understand it better now! Worth reading.

"In conclusion, our results support evidence that lactate regulates the glycolytic flux through modulating PFK due to its effects on the enzyme quaternary structure."

https://t.co/CqhQxZZ0HM

[Aitor Viribay @MVAitor]

Lactate is known as a preferred fuel for the cell. But it’s also an important signaling molecule👇🏼

Can it help in muscle cell differentiation and hypertrophy, and result in better muscle regeneration?💪

📍Check this paper (interesting, not conclusive…): https://t.co/HEUILeOKPA

[Aitor Viribay @MVAitor]

One of my most valuable learnings that has shaped how I understand metabolism:

👉🏼 “Stress doesn’t always mean adaptation, although stress is a condition to adapt.”

Applied to cellular level (⬆️PGC1α ≠ always ⬆️mito proteins) or organism level (⬆️training load ≠ ⬆️results).

[Aitor Viribay @MVAitor]

1/3 Why do you feel weak when you’re sick (e.g., viral infection)? Why do muscles hurt?

It is INSULIN RESISTANCE (acute). That’s how it feels like.🤯 Interesting, isn’t it?

Sickness response activates pro-inflammatory cytokines that altere insulin signaling pathways.

But why?

[Aitor Viribay @MVAitor]

Lactate is a buffer agent, but not only on pH.

👉🏼 Lactate buffers CARBOHYDRATES in the body.

🛩️🆙 Lactate elevates up the travelling status of carbons: from traveling in Economy (glucose) to a privilege seat in Business (Lactate) 😜

Read this paper 👇🏼

https://t.co/Hpdi2vfyk3

[Aitor Viribay @MVAitor]

This is the reason why sometimes high carbohydrate interventions are not considered effective or adequate to the exercise purpose by athletes, practitioners or scientists.

[Aitor Viribay @MVAitor]

Lactate cannot be understood without its specific transporters, MCTs.

This paper shows how MCT1 (high affinity with lactate - involved in influx to the cell and mitochondria) impacts on the substrate shift and metabolic reprogramming.

Worth reading: https://t.co/DCD7BpZpXf

[Aitor Viribay @MVAitor]

Things were serious today… 🥵🤯

Anyone guessing the reading on the Lactate Plus for the same sample?

What’s the difference between Lactate Pro 2 and Lactate Plus monitors?

Check this reference to begin with:
https://t.co/BaZGEWw0J0

[Aitor Viribay @MVAitor]

@Glut4Science 22- Is lactate buffer agent?

Lactate always travels with an H+, meaning traveling in or out of the cell, through MCT1 or MCT4, it will always play a key role in regulating the overall pH of the body - intra and extracellular.

It all depends on the fiber’s redox state!! 🤓🩸

[Aitor Viribay @MVAitor]

Today’s paper on Lactate Metabolism.

A good narrative review by Li, X. et al.

“An indispensable substance for various physiological cellular functions, lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.”

https://t.co/QPBoGWAZg5

[Aitor Viribay @MVAitor]

Thank you @tntsports for highlighting our work at Salomon.

We keep improving as a team to help our athletes developing themselves as healthy and high performance individuals.

https://t.co/Pl5070WxCo

[Aitor Viribay @MVAitor]

The paper of the day.

If you really want to learn about Lactate and its role as regulator of genes expression, this is a good reference.

https://t.co/XtWjbGnlV3

[Aitor Viribay @MVAitor]

Lactate is suggested to be neuroprotective after brain injury - better than ketones? - which might be a potential treatment, for example, in concussions after a crash - high speed sports like cycling, motorsports…

This research studies it:
https://t.co/luepl8ArMu