Ethan Goldberg

Pediatric neurologist; Neurogeneticist; Neurobiologist; Fantasy Baseball player; Amateur chess enthusiast; Dad.

[Ethan Goldberg @Go3than]

This study was led by superstar postdoctoral fellow Sophie Hill, Ph.D., and supported by @curedravet and the JumpStart Research Tools Matching Grant Program from @ODC_UPenn. Thanks as well to the SCN1A Gain of Function Foundation.

[Ethan Goldberg @Go3than]

Loss of function variants in SCN1A cause Dravet syndrome, the most common/well known genetic epilepsy. Gain of function also causes a severe - albeit less common - neurodevelopmental disorder. We made the first mouse model of SCN1A GoF epilepsy: https://t.co/gjxiTYkGdU

[David R. Liu @davidrliu]

This work was a wonderful three-institution collaboration among @broadinstitute, @jacksonlab, and @ChildrensPhila co-led by @Andrew_TNelson, Sophie Hill, and Matthew Simon, with key contributions from Jérôme Clatot, @HoltSakai, Jun Xie, @AlexanderASousa, @meirui_an, Guangping Gao. This project was co-directed by Cat Lutz and Ethan Goldberg (@Go3than) . Congratulations to the team!
12/13
https://t.co/QDi63QG2Nq

[Ethan Goldberg @Go3than]

We have 2 Research Tech positions to support research related to mechanisms of neurodevelopmental disorders: https://t.co/MZDbBMITe2 Please share the link. This would be great for a few years prior to applying to MD, PhD, or MD/PhD programs, or transitioning to industry.

[Ethan Goldberg @Go3than]

Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons https://t.co/OdTunFBg3c

[Ethan Goldberg @Go3than]

New study led by postdoc Sophie Hill in collaboration @GordFishell @YatingWang1 et al: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome https://t.co/b8fWYnkmRF

[Ethan Goldberg @Go3than]

Job Alert! Administrative Manager for new Center for Brain Research in Development, Genetics, and Engineering (BRIDGE Center) at the Children's Hospital of Philadelphia to provide admin leadership and support Center operations. Apply here: https://t.co/R45MLngrWT

[Ethan Goldberg @Go3than]

Job Alert! Technical Director to lead the Behavioral Evaluation of Advanced Model Systems (BEAMS) Hub of the BRIDGE Center https://t.co/tq5qR9VCpr at Children's Hosp of Philadelphia. Great for a senior postdoc or research associate w/ expertise in behavior https://t.co/rhgg54j5Fn

[Attila Losonczy @attila_losonczy]

Please consider applying for the 2025 Gordon Conference on Inhibition and the preceding Gordon Research Seminar on Inhibitory Cascades in the CNS.  https://t.co/37IS5qYWaP…Great lineup

[Ethan Goldberg @Go3than]

Rare variants in epilepsy- and autism-linked gene SCN2A are associated with malformation of cortical development, supporting role of NaV1.2 in early brain development: https://t.co/a6DuHykn53
Fun collaboration w/ @nupharm1 @NicolaSpecchio_ @r_guerrini Supported by @NIH_NINDS

[Ethan Goldberg @Go3than]

New collaboration with @davidrliu to pursue base editing in a Dravet syndrome model.
Thanks to @curedravet for your leadership and vision and continued support of our work to improve the lives of patients with Dravet Syndrome.
https://t.co/5dZLjYCOfm

[Ethan Goldberg @Go3than]

Rising star @ZPRosenthal PGY-3 Resident @PennPsych uses a novel mouse model of electroconvulsive therapy (ECT) and DCS/FD-DOS in humans to show that: ECT generates a hidden wave - CSD - after seizure https://t.co/QBqspKzIV0

[Ethan Goldberg @Go3than]

From postdoc Sophie Hill in a fun collaboration w/ EAP expert @TheyelLab supported by @curedravet : Attenuated Ectopic Action Potential firing in PV interneurons in a mouse model of Dravet Syndrome https://t.co/1TiqkCLXdt
The function of EAPs remains under investigation...

[Ethan Goldberg @Go3than]

Postdoc Eric Wengert (brain slice physiologist + educator extraordinaire) teams up with @PennNGG MDPhD student @sophie_liebs and three @Penn undergrads: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy: https://t.co/8lzGFnc2r3

[Ethan Goldberg @Go3than]

We are recruiting to two (2) Tenure-Track Assistant Professor positions in the new BRIDGE Center (Brain Research In Development, Genetics, & Engineering) at The Children's Hospital of Philadelphia/University of Pennsylvania.

Details here: https://t.co/oDcXicVxUE

[Amy Salovin @ASalovin]

Excited for Neuroscience 2024: Mechanisms and Emerging Therapies for Brain Disorders of Childhood. All @CHOPResearch and Penn faculty, staff and trainees are welcome. Join us to celebrate groundbreaking research and network with peers! Learn more: https://t.co/FpOGeh75wV

[Ethan Goldberg @Go3than]

Superstar @PennNGG student @sophie_liebs throws the kitchen sink at Layer 1 Ndnf cells to show unique preservation of Ndnf interneuron excitability among the major neocortical GABAergic interneuron subtypes in a mouse model of Dravet syndrome. https://t.co/y8A47lLGle

[Ethan Goldberg @Go3than]

@AmauryguichonTV I would love to know how he comes up with these ideas. The execution of course is incredible, but the creativity is absolutely amazing.

[Ethan Goldberg @Go3than]

@AmauryguichonTV Possibly the best one yet. Absolutely brilliant.

[Ethan Goldberg @Go3than]

@pvalbpapers1 I can check this off my bucket list: a tweet from @pvalbpapers1! Thanks!!