I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod@friedberg@chamath@pesottas
An absolutely incredible performance by Spain to take home the World Cup! 🇪🇸🏆 So well-deserved, just a beautiful display of teamwork all tournament. Congratulations to Argentina & Messi on a great run. And huge kudos to all of the teams and fans around the world for making this World Cup so memorable, already looking forward to 2030!
BREAKING: SpaceX is now targeting Thursday, July 23, for Starship’s 13th flight test.
The mission will attempt to deploy 20 Starlink V3 satellites, relight a Raptor engine in space, test Super Heavy’s boostback and landing burns, and complete a controlled splashdown.
BREAKING: Grok 4.5 leads VulcanBench’s new coding benchmark. 🔥
Grok scored 91.3%, solving 21 of 23 real-world software tasks across five languages, beating Claude Fable 5 and GPT-5.6 Sol while also owning the cost-efficiency frontier.
Grok keeps winning. 🏆
Grok accurately predicted that Spain would win the FIFA World Cup 🏆
Here’s how it arrived at the prediction:
Before the 2026 FIFA World Cup even began, Grok picked Spain to become champion
Back in April, it analyzed betting odds, prediction markets and supercomputer forecasts, concluding that Spain had the highest probability of winning
Months later...
Spain lifted the World Cup trophy
A great example of Grok combining multiple independent signals to identify the most likely outcome before the tournament even began
Grok is once again proving exceptionally strong at prediction and forecasting
Starlink’s progress in under seven years is totally insane
2019 — The first dedicated Starlink launch carried 60 satellites
2020 — Wider public beta service began
2024 — The first Direct to Cell satellites launched, followed by the first commercial satellite-texting rollout
2025 — Direct to Cell expanded across more carriers, devices and markets
2026 — Starlink reached approximately 10.3 million subscribers across 164 countries, territories and other markets
By March 31, 2026, SpaceX had approximately 9,600 Starlink broadband and mobile satellites in low-Earth orbit
Direct to Cell was already providing satellite-to-mobile texting and voice services to approximately 7.4 million monthly unique devices across roughly 30 countries
What began with a single launch of 60 satellites is becoming a global communications layer connecting homes, businesses, aircraft, ships, government operations, rescue missions and ordinary smartphones
SpaceX is building connectivity infrastructure for the entire planet
BREAKING: Grok 4.5 leads VulcanBench’s new coding benchmark. 🔥
Grok scored 91.3%, solving 21 of 23 real-world software tasks across five languages, beating Claude Fable 5 and GPT-5.6 Sol while also owning the cost-efficiency frontier.
Grok keeps winning. 🏆
The first phone call across the Atlantic, in 1927, cost about seventy five dollars for three minutes, more than a thousand in today's money. Right now you can see a face on the other side of the planet, in real time, for free.
SpaceX's newest satellites carry about 1,024 gigabits of bandwidth each. The generation before carried 96. That is a tenfold leap in a single design cycle, beamed down from orbit. Jumps like that do not happen in industries that have given up, if so can you name me any?
Throwback to 2014: Elon Musk gives a tour inside the brand-new Dragon V2
An early glimpse of Elon showing America the spacecraft that would eventually restore its ability to launch astronauts into orbit from its own soil
I don’t think people realize how absurd this is. Scottish runner Josh Kerr just broke the mile world record in 3:42.66, an average speed of 16.2 mph. Most people couldn’t even briefly reach that speed, let alone sustain it for an entire mile.